Transcriptome-Wide Mapping of Small-Molecule RNA-Binding Sites in Cells Informs an Isoform-Specific Degrader of QSOX1 mRNA

The interactions between cellular RNAs in MDA-MB-231 triple negative breast cancer cells and a panel of small molecules appended with a diazirine cross-linking moiety and an alkyne tag were probed transcriptome-wide in live cells. The alkyne tag allows for facile pull-down of cellular RNAs bound by...

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Veröffentlicht in:	Journal of the American Chemical Society 2022-07, Vol.144 (26), p.11620-11625
Hauptverfasser:	Tong, Yuquan, Gibaut, Quentin M. R., Rouse, Warren, Childs-Disney, Jessica L., Suresh, Blessy M., Abegg, Daniel, Choudhary, Shruti, Akahori, Yoshihiro, Adibekian, Alexander, Moss, Walter N., Disney, Matthew D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes Binding Sites Oxidoreductases Acting on Sulfur Group Donors - metabolism Protein Isoforms - metabolism Ribonucleases - metabolism RNA RNA, Messenger - genetics RNA, Messenger - metabolism Transcriptome
Online-Zugang:	Volltext
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