Methicillin-resistant Staphylococcus aureus Necrotizing Bronchitis after Radiotherapy in Combination with Axitinib
A 38-year-old man with renal cell carcinoma was referred to our hospital because of a productive cough. He had received radiotherapy for lung metastasis and been treated with axitinib. Bronchoscopy revealed necrosis in the bronchi of the right middle and lower lobes. Culture of the necrotic bronchia...
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| Veröffentlicht in: | Internal Medicine 2022/10/01, Vol.61(19), pp.2931-2934 |
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| container_title | Internal Medicine |
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| creator | Nakatsumi, Hiroki Watanabe, Satoshi Gohara, Kazuki Kobayashi, Takafumi Takeda, Yoshihiro Kasahara, Kazuo Yano, Seiji |
| description | A 38-year-old man with renal cell carcinoma was referred to our hospital because of a productive cough. He had received radiotherapy for lung metastasis and been treated with axitinib. Bronchoscopy revealed necrosis in the bronchi of the right middle and lower lobes. Culture of the necrotic bronchial specimen revealed methicillin-resistant Staphylococcus aureus (MRSA). Although radiotherapy in combination with axitinib carries a risk of causing airway toxicity, MRSA necrotizing bronchitis has not been reported. Physicians should consider the possibility of infectious necrotizing bronchitis if irradiated patients show prolonged respiratory symptoms. |
| doi_str_mv | 10.2169/internalmedicine.9143-21 |
| format | Article |
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Physicians should consider the possibility of infectious necrotizing bronchitis if irradiated patients show prolonged respiratory symptoms.</description><identifier>ISSN: 0918-2918</identifier><identifier>EISSN: 1349-7235</identifier><identifier>DOI: 10.2169/internalmedicine.9143-21</identifier><identifier>PMID: 35228430</identifier><language>eng</language><publisher>Tokyo: The Japanese Society of Internal Medicine</publisher><subject>angiogenesis inhibitor ; axitinib ; Bronchitis ; Bronchoscopy ; Bronchus ; Case Report ; Cell culture ; Cough ; Drug resistance ; Internal medicine ; Metastases ; Methicillin ; MRSA ; necrotizing bronchitis ; Radiation therapy ; radiotherapy ; Renal cell carcinoma ; Staphylococcus aureus ; Toxicity</subject><ispartof>Internal Medicine, 2022/10/01, Vol.61(19), pp.2931-2934</ispartof><rights>2022 by The Japanese Society of Internal Medicine</rights><rights>Copyright Japan Science and Technology Agency 2022</rights><rights>Copyright © 2022 by The Japanese Society of Internal Medicine</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c587t-9a8d715c0928482747f476dbae39ecbb00641f4254f8389628fa40835cad9fa73</citedby><cites>FETCH-LOGICAL-c587t-9a8d715c0928482747f476dbae39ecbb00641f4254f8389628fa40835cad9fa73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593151/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9593151/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,1877,27905,27906,53772,53774</link.rule.ids></links><search><creatorcontrib>Nakatsumi, Hiroki</creatorcontrib><creatorcontrib>Watanabe, Satoshi</creatorcontrib><creatorcontrib>Gohara, Kazuki</creatorcontrib><creatorcontrib>Kobayashi, Takafumi</creatorcontrib><creatorcontrib>Takeda, Yoshihiro</creatorcontrib><creatorcontrib>Kasahara, Kazuo</creatorcontrib><creatorcontrib>Yano, Seiji</creatorcontrib><title>Methicillin-resistant Staphylococcus aureus Necrotizing Bronchitis after Radiotherapy in Combination with Axitinib</title><title>Internal Medicine</title><addtitle>Intern. Med.</addtitle><description>A 38-year-old man with renal cell carcinoma was referred to our hospital because of a productive cough. He had received radiotherapy for lung metastasis and been treated with axitinib. Bronchoscopy revealed necrosis in the bronchi of the right middle and lower lobes. Culture of the necrotic bronchial specimen revealed methicillin-resistant Staphylococcus aureus (MRSA). Although radiotherapy in combination with axitinib carries a risk of causing airway toxicity, MRSA necrotizing bronchitis has not been reported. Physicians should consider the possibility of infectious necrotizing bronchitis if irradiated patients show prolonged respiratory symptoms.</description><subject>angiogenesis inhibitor</subject><subject>axitinib</subject><subject>Bronchitis</subject><subject>Bronchoscopy</subject><subject>Bronchus</subject><subject>Case Report</subject><subject>Cell culture</subject><subject>Cough</subject><subject>Drug resistance</subject><subject>Internal medicine</subject><subject>Metastases</subject><subject>Methicillin</subject><subject>MRSA</subject><subject>necrotizing bronchitis</subject><subject>Radiation therapy</subject><subject>radiotherapy</subject><subject>Renal cell carcinoma</subject><subject>Staphylococcus aureus</subject><subject>Toxicity</subject><issn>0918-2918</issn><issn>1349-7235</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNplkUtv1DAUhS0EokPhP0RiwybFz8TeIJVRaZEKlXisLcdxJneUsQfbAYZfj6MZjUTZ3Lu453w6ugehiuArShr1Fnx20Ztp53qw4N2VIpzVlDxBK8K4qlvKxFO0worImpZxgV6ktMWYyVbR5-iCCUolZ3iF4ieXx8KYJvB1dAlSNj5XX7PZj4cp2GDtnCozR1fWZ2djyPAH_KZ6H4O3I2Qo16Gkqb6YHkIeXTT7QwW-WoddB95kCL76BXmsrn8XtYfuJXo2mCm5V6d9ib5_uPm2vqvvH24_rq_vaytkm2tlZN8SYbEqUSVteTvwtuk745hytuswbjgZOBV8kEyqhsrBcCyZsKZXg2nZJXp35O7nrjzKOp-jmfQ-ws7Egw4G9L8XD6PehJ9aCcWIIAXw5gSI4cfsUtY7SNZNk_EuzEnThnEpiBBNkb5-JN2GeWmoqFqKCcGELUB5VJU3phTdcA5DsF6K1Y-L1Uux5VSsD0frthS0cWejiRns5P43NkQTtcwT4ay0o4naefYX3dy7Jw</recordid><startdate>20221001</startdate><enddate>20221001</enddate><creator>Nakatsumi, Hiroki</creator><creator>Watanabe, Satoshi</creator><creator>Gohara, Kazuki</creator><creator>Kobayashi, Takafumi</creator><creator>Takeda, Yoshihiro</creator><creator>Kasahara, Kazuo</creator><creator>Yano, Seiji</creator><general>The Japanese Society of Internal Medicine</general><general>Japan Science and Technology Agency</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20221001</creationdate><title>Methicillin-resistant Staphylococcus aureus Necrotizing Bronchitis after Radiotherapy in Combination with Axitinib</title><author>Nakatsumi, Hiroki ; Watanabe, Satoshi ; Gohara, Kazuki ; Kobayashi, Takafumi ; Takeda, Yoshihiro ; Kasahara, Kazuo ; Yano, Seiji</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c587t-9a8d715c0928482747f476dbae39ecbb00641f4254f8389628fa40835cad9fa73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>angiogenesis inhibitor</topic><topic>axitinib</topic><topic>Bronchitis</topic><topic>Bronchoscopy</topic><topic>Bronchus</topic><topic>Case Report</topic><topic>Cell culture</topic><topic>Cough</topic><topic>Drug resistance</topic><topic>Internal medicine</topic><topic>Metastases</topic><topic>Methicillin</topic><topic>MRSA</topic><topic>necrotizing bronchitis</topic><topic>Radiation therapy</topic><topic>radiotherapy</topic><topic>Renal cell carcinoma</topic><topic>Staphylococcus aureus</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakatsumi, Hiroki</creatorcontrib><creatorcontrib>Watanabe, Satoshi</creatorcontrib><creatorcontrib>Gohara, Kazuki</creatorcontrib><creatorcontrib>Kobayashi, Takafumi</creatorcontrib><creatorcontrib>Takeda, Yoshihiro</creatorcontrib><creatorcontrib>Kasahara, Kazuo</creatorcontrib><creatorcontrib>Yano, Seiji</creatorcontrib><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Internal Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakatsumi, Hiroki</au><au>Watanabe, Satoshi</au><au>Gohara, Kazuki</au><au>Kobayashi, Takafumi</au><au>Takeda, Yoshihiro</au><au>Kasahara, Kazuo</au><au>Yano, Seiji</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methicillin-resistant Staphylococcus aureus Necrotizing Bronchitis after Radiotherapy in Combination with Axitinib</atitle><jtitle>Internal Medicine</jtitle><addtitle>Intern. Med.</addtitle><date>2022-10-01</date><risdate>2022</risdate><volume>61</volume><issue>19</issue><spage>2931</spage><epage>2934</epage><pages>2931-2934</pages><artnum>9143-21</artnum><issn>0918-2918</issn><eissn>1349-7235</eissn><abstract>A 38-year-old man with renal cell carcinoma was referred to our hospital because of a productive cough. He had received radiotherapy for lung metastasis and been treated with axitinib. Bronchoscopy revealed necrosis in the bronchi of the right middle and lower lobes. Culture of the necrotic bronchial specimen revealed methicillin-resistant Staphylococcus aureus (MRSA). Although radiotherapy in combination with axitinib carries a risk of causing airway toxicity, MRSA necrotizing bronchitis has not been reported. Physicians should consider the possibility of infectious necrotizing bronchitis if irradiated patients show prolonged respiratory symptoms.</abstract><cop>Tokyo</cop><pub>The Japanese Society of Internal Medicine</pub><pmid>35228430</pmid><doi>10.2169/internalmedicine.9143-21</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | angiogenesis inhibitor axitinib Bronchitis Bronchoscopy Bronchus Case Report Cell culture Cough Drug resistance Internal medicine Metastases Methicillin MRSA necrotizing bronchitis Radiation therapy radiotherapy Renal cell carcinoma Staphylococcus aureus Toxicity |
| title | Methicillin-resistant Staphylococcus aureus Necrotizing Bronchitis after Radiotherapy in Combination with Axitinib |
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