Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation
Corilagin, a gallotannin, shows excellent antioxidant and anti-inflammatory effects. The NLRP3 inflammasome dysfunction has been implicated in a variety of inflammation diseases. However, it remains unclear how corilagin regulates the NLRP3 inflammasome to relieve gouty arthritis. In this study, bon...
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| container_title | Oxidative medicine and cellular longevity |
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| creator | Luo, Tianyu Zhou, Xiaoyi Qin, Minyan Lin, Yuqing Lin, Jiefen Chen, Guangpei Liu, Aijun Ouyang, Dongyun Chen, Dongfeng Pan, Hao |
| description | Corilagin, a gallotannin, shows excellent antioxidant and anti-inflammatory effects. The NLRP3 inflammasome dysfunction has been implicated in a variety of inflammation diseases. However, it remains unclear how corilagin regulates the NLRP3 inflammasome to relieve gouty arthritis. In this study, bone marrow-derived macrophages (BMDMs) were pretreated with lipopolysaccharide (LPS) and then incubated with NLRP3 inflammasome agonists, such as adenine nucleoside triphosphate (ATP), nigericin, and monosodium urate (MSU) crystals. The MSU crystals were intra-articular injected to induce acute gouty arthritis. Here we showed that corilagin reduced lactate dehydrogenase (LDH) secretion and the proportion of propidium iodide- (PI-)stained cells. Corilagin suppressed the expression of N-terminal of the pyroptosis executive protein gasdermin D (GSDMD-NT). Corilagin restricted caspase-1 p20 and interleukin (IL)-1β release. Meanwhile, corilagin attenuated ASC oligomerization and speck formation. Our findings confirmed that corilagin diminished NLRP3 inflammasome activation and macrophage pyroptosis. We further discovered that corilagin limited the mitochondrial reactive oxygen species (ROS) production and prevented the interaction between TXNIP and NLRP3, but ROS activator imiquimod could antagonize the inhibitory function of corilagin on NLRP3 inflammasome and macrophage pyroptosis. Additionally, corilagin ameliorated MSU crystals induced joint swelling, inhibited IL-1β production, and abated macrophage and neutrophil migration into the joint capsule. Collectively, these results demonstrated that corilagin suppressed the ROS/TXNIP/NLRP3 pathway to repress inflammasome activation and pyroptosis and suggest its potential antioxidative role in alleviating NLRP3-dependent gouty arthritis. |
| doi_str_mv | 10.1155/2022/1652244 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9592212</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2729530104</sourcerecordid><originalsourceid>FETCH-LOGICAL-c425t-fdaf7e4ba4665590a17877dfa56e047efb17b081339b3f818edadf1beaf2f6843</originalsourceid><addsrcrecordid>eNp9kU1rGzEQhpeQQvN16w8Q5BJoXEtaaT8ugWCS1mCSxUmhNzG7K3kVdiVX0joY-uMrY2NoDj2NYB6emdGbJF8I_kYI51OKKZ2SjFPK2ElyRkpGJ7gs2enxjfHn5Nz7N4yzlDJylvyZWad7WGmDltIHB9p49LRYVimaG9XDMIC3g0T3TdAbCNoaBKZF1dbZdbBeexQ6Z8dVF6tEy-eX6euvp3k13SsqCN07bFGwqHJyI004Wneqy-STgt7Lq0O9SH4-PrzOfkwWz9_ns_vFpGGUh4lqQeWS1cCyjPMSA8mLPG8V8ExilktVk7zGBUnTsk5VQQrZQqtILUFRlRUsvUju9t71WA-ybeIeDnqxdnoAtxUWtPi3Y3QnVnYjSl5SSmgU3BwEzv4e4z-JQftG9j0YaUcvaE5LnmKCd7OuP6BvdnQmnhepiPCM50WkbvdU46z3TqrjMgSLXZZil6U4ZBnxr3u806aFd_1_-i_2jZ_N</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2730156578</pqid></control><display><type>article</type><title>Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation</title><source>Wiley Online Library Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>PubMed Central Open Access</source><creator>Luo, Tianyu ; Zhou, Xiaoyi ; Qin, Minyan ; Lin, Yuqing ; Lin, Jiefen ; Chen, Guangpei ; Liu, Aijun ; Ouyang, Dongyun ; Chen, Dongfeng ; Pan, Hao</creator><contributor>Zheng, Tao ; Tao Zheng</contributor><creatorcontrib>Luo, Tianyu ; Zhou, Xiaoyi ; Qin, Minyan ; Lin, Yuqing ; Lin, Jiefen ; Chen, Guangpei ; Liu, Aijun ; Ouyang, Dongyun ; Chen, Dongfeng ; Pan, Hao ; Zheng, Tao ; Tao Zheng</creatorcontrib><description>Corilagin, a gallotannin, shows excellent antioxidant and anti-inflammatory effects. The NLRP3 inflammasome dysfunction has been implicated in a variety of inflammation diseases. However, it remains unclear how corilagin regulates the NLRP3 inflammasome to relieve gouty arthritis. In this study, bone marrow-derived macrophages (BMDMs) were pretreated with lipopolysaccharide (LPS) and then incubated with NLRP3 inflammasome agonists, such as adenine nucleoside triphosphate (ATP), nigericin, and monosodium urate (MSU) crystals. The MSU crystals were intra-articular injected to induce acute gouty arthritis. Here we showed that corilagin reduced lactate dehydrogenase (LDH) secretion and the proportion of propidium iodide- (PI-)stained cells. Corilagin suppressed the expression of N-terminal of the pyroptosis executive protein gasdermin D (GSDMD-NT). Corilagin restricted caspase-1 p20 and interleukin (IL)-1β release. Meanwhile, corilagin attenuated ASC oligomerization and speck formation. Our findings confirmed that corilagin diminished NLRP3 inflammasome activation and macrophage pyroptosis. We further discovered that corilagin limited the mitochondrial reactive oxygen species (ROS) production and prevented the interaction between TXNIP and NLRP3, but ROS activator imiquimod could antagonize the inhibitory function of corilagin on NLRP3 inflammasome and macrophage pyroptosis. Additionally, corilagin ameliorated MSU crystals induced joint swelling, inhibited IL-1β production, and abated macrophage and neutrophil migration into the joint capsule. Collectively, these results demonstrated that corilagin suppressed the ROS/TXNIP/NLRP3 pathway to repress inflammasome activation and pyroptosis and suggest its potential antioxidative role in alleviating NLRP3-dependent gouty arthritis.</description><identifier>ISSN: 1942-0900</identifier><identifier>EISSN: 1942-0994</identifier><identifier>DOI: 10.1155/2022/1652244</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Adenosine triphosphate ; Antibodies ; Apoptosis ; Arthritis ; Bone marrow ; Cell culture ; Chinese medicine ; Cytokines ; Cytotoxicity ; Enzymes ; Inflammation ; Laboratory animals ; Life sciences ; Mitochondrial DNA ; Neutrophils ; Pathogens ; Proteins ; Reactive oxygen species ; Tumor necrosis factor-TNF</subject><ispartof>Oxidative medicine and cellular longevity, 2022-10, Vol.2022, p.1-26</ispartof><rights>Copyright © 2022 Tianyu Luo et al.</rights><rights>Copyright © 2022 Tianyu Luo et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Tianyu Luo et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-fdaf7e4ba4665590a17877dfa56e047efb17b081339b3f818edadf1beaf2f6843</citedby><cites>FETCH-LOGICAL-c425t-fdaf7e4ba4665590a17877dfa56e047efb17b081339b3f818edadf1beaf2f6843</cites><orcidid>0000-0002-2049-1842 ; 0000-0003-1263-2374</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592212/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9592212/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids></links><search><contributor>Zheng, Tao</contributor><contributor>Tao Zheng</contributor><creatorcontrib>Luo, Tianyu</creatorcontrib><creatorcontrib>Zhou, Xiaoyi</creatorcontrib><creatorcontrib>Qin, Minyan</creatorcontrib><creatorcontrib>Lin, Yuqing</creatorcontrib><creatorcontrib>Lin, Jiefen</creatorcontrib><creatorcontrib>Chen, Guangpei</creatorcontrib><creatorcontrib>Liu, Aijun</creatorcontrib><creatorcontrib>Ouyang, Dongyun</creatorcontrib><creatorcontrib>Chen, Dongfeng</creatorcontrib><creatorcontrib>Pan, Hao</creatorcontrib><title>Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation</title><title>Oxidative medicine and cellular longevity</title><description>Corilagin, a gallotannin, shows excellent antioxidant and anti-inflammatory effects. The NLRP3 inflammasome dysfunction has been implicated in a variety of inflammation diseases. However, it remains unclear how corilagin regulates the NLRP3 inflammasome to relieve gouty arthritis. In this study, bone marrow-derived macrophages (BMDMs) were pretreated with lipopolysaccharide (LPS) and then incubated with NLRP3 inflammasome agonists, such as adenine nucleoside triphosphate (ATP), nigericin, and monosodium urate (MSU) crystals. The MSU crystals were intra-articular injected to induce acute gouty arthritis. Here we showed that corilagin reduced lactate dehydrogenase (LDH) secretion and the proportion of propidium iodide- (PI-)stained cells. Corilagin suppressed the expression of N-terminal of the pyroptosis executive protein gasdermin D (GSDMD-NT). Corilagin restricted caspase-1 p20 and interleukin (IL)-1β release. Meanwhile, corilagin attenuated ASC oligomerization and speck formation. Our findings confirmed that corilagin diminished NLRP3 inflammasome activation and macrophage pyroptosis. We further discovered that corilagin limited the mitochondrial reactive oxygen species (ROS) production and prevented the interaction between TXNIP and NLRP3, but ROS activator imiquimod could antagonize the inhibitory function of corilagin on NLRP3 inflammasome and macrophage pyroptosis. Additionally, corilagin ameliorated MSU crystals induced joint swelling, inhibited IL-1β production, and abated macrophage and neutrophil migration into the joint capsule. 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The NLRP3 inflammasome dysfunction has been implicated in a variety of inflammation diseases. However, it remains unclear how corilagin regulates the NLRP3 inflammasome to relieve gouty arthritis. In this study, bone marrow-derived macrophages (BMDMs) were pretreated with lipopolysaccharide (LPS) and then incubated with NLRP3 inflammasome agonists, such as adenine nucleoside triphosphate (ATP), nigericin, and monosodium urate (MSU) crystals. The MSU crystals were intra-articular injected to induce acute gouty arthritis. Here we showed that corilagin reduced lactate dehydrogenase (LDH) secretion and the proportion of propidium iodide- (PI-)stained cells. Corilagin suppressed the expression of N-terminal of the pyroptosis executive protein gasdermin D (GSDMD-NT). Corilagin restricted caspase-1 p20 and interleukin (IL)-1β release. Meanwhile, corilagin attenuated ASC oligomerization and speck formation. Our findings confirmed that corilagin diminished NLRP3 inflammasome activation and macrophage pyroptosis. We further discovered that corilagin limited the mitochondrial reactive oxygen species (ROS) production and prevented the interaction between TXNIP and NLRP3, but ROS activator imiquimod could antagonize the inhibitory function of corilagin on NLRP3 inflammasome and macrophage pyroptosis. Additionally, corilagin ameliorated MSU crystals induced joint swelling, inhibited IL-1β production, and abated macrophage and neutrophil migration into the joint capsule. Collectively, these results demonstrated that corilagin suppressed the ROS/TXNIP/NLRP3 pathway to repress inflammasome activation and pyroptosis and suggest its potential antioxidative role in alleviating NLRP3-dependent gouty arthritis.</abstract><cop>New York</cop><pub>Hindawi</pub><doi>10.1155/2022/1652244</doi><tpages>26</tpages><orcidid>https://orcid.org/0000-0002-2049-1842</orcidid><orcidid>https://orcid.org/0000-0003-1263-2374</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenosine triphosphate Antibodies Apoptosis Arthritis Bone marrow Cell culture Chinese medicine Cytokines Cytotoxicity Enzymes Inflammation Laboratory animals Life sciences Mitochondrial DNA Neutrophils Pathogens Proteins Reactive oxygen species Tumor necrosis factor-TNF |
| title | Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation |
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