Treatment of Gout with TCM Using Turmeric and Corn Silk: A Concise Review Article and Pharmacology Network Analysis
Objective. This work aimed to study the compounds, targets, and pathways of turmeric and corn silk for gout and to explore the mechanism of “the same disease with different treatments” based on network pharmacology and molecular docking. Methods. We used the TCMSP, PubChem, and SEA databases to scre...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2022-10, Vol.2022, p.1-18 |
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| creator | Zhang, Haoyu Jiang, Huizhong Zhao, Mengya Xu, Yan Liang, Jiabin Ye, Yufeng Chen, Hanwei |
| description | Objective. This work aimed to study the compounds, targets, and pathways of turmeric and corn silk for gout and to explore the mechanism of “the same disease with different treatments” based on network pharmacology and molecular docking. Methods. We used the TCMSP, PubChem, and SEA databases to screen the compounds and targets of turmeric and corn silk, gout-related proteins through TTD, Drugbank, DisGeNET, GeneCards, OMIM, and PharmGkb, and used Cytoscape to construct a “compound-target-disease” network. Then, we constructed a protein-protein interaction network (PPI) and used Metascape to perform GO and KEGG analysis. Finally, molecular docking (SYBYL) was used to verify the degree of binding between key targets and compounds. Results. We found bisacumol, campesterol, and stigmasterol to be the main turmeric compounds that exerted a marked effect on gout treatment by targeting protein processing in the endoplasmic reticulum through the HSPA1B, HSP90AB1, and STUB1 proteins. The main corn silk compound, Mandenol, treated gout by targeting the Hippo signaling pathway through the CTNNB1, YWHAG, and YWHAZ proteins. Conclusion. Turmeric and corn silk can treat the same disease, gout, through different pathways and targets. The scientific connotation of “same disease with different treatments” can be preliminarily clarified by analyzing targets and pathways. |
| doi_str_mv | 10.1155/2022/3143733 |
| format | Article |
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This work aimed to study the compounds, targets, and pathways of turmeric and corn silk for gout and to explore the mechanism of “the same disease with different treatments” based on network pharmacology and molecular docking. Methods. We used the TCMSP, PubChem, and SEA databases to screen the compounds and targets of turmeric and corn silk, gout-related proteins through TTD, Drugbank, DisGeNET, GeneCards, OMIM, and PharmGkb, and used Cytoscape to construct a “compound-target-disease” network. Then, we constructed a protein-protein interaction network (PPI) and used Metascape to perform GO and KEGG analysis. Finally, molecular docking (SYBYL) was used to verify the degree of binding between key targets and compounds. Results. We found bisacumol, campesterol, and stigmasterol to be the main turmeric compounds that exerted a marked effect on gout treatment by targeting protein processing in the endoplasmic reticulum through the HSPA1B, HSP90AB1, and STUB1 proteins. The main corn silk compound, Mandenol, treated gout by targeting the Hippo signaling pathway through the CTNNB1, YWHAG, and YWHAZ proteins. Conclusion. Turmeric and corn silk can treat the same disease, gout, through different pathways and targets. The scientific connotation of “same disease with different treatments” can be preliminarily clarified by analyzing targets and pathways.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2022/3143733</identifier><language>eng</language><publisher>New York: Hindawi</publisher><subject>Arthritis ; Chinese medicine ; Corn ; Disease ; Endoplasmic reticulum ; Gout ; Pharmacology ; Protein interaction ; Proteins ; Rheumatism ; Signal transduction ; Software ; Uric acid</subject><ispartof>Evidence-based complementary and alternative medicine, 2022-10, Vol.2022, p.1-18</ispartof><rights>Copyright © 2022 Haoyu Zhang et al.</rights><rights>Copyright © 2022 Haoyu Zhang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Haoyu Zhang et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c425t-2791696bcde51eb7e67c9e768af7bbd75f92bdafc8fff875ce6a88f7de6fbe543</citedby><cites>FETCH-LOGICAL-c425t-2791696bcde51eb7e67c9e768af7bbd75f92bdafc8fff875ce6a88f7de6fbe543</cites><orcidid>0000-0002-9618-542X ; 0000-0003-0636-5302 ; 0000-0002-1047-9786 ; 0000-0001-5258-339X ; 0000-0002-9843-475X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586733/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9586733/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,728,781,785,886,27928,27929,53795,53797</link.rule.ids></links><search><contributor>El Sayed, Salah M.</contributor><contributor>Salah M El Sayed</contributor><creatorcontrib>Zhang, Haoyu</creatorcontrib><creatorcontrib>Jiang, Huizhong</creatorcontrib><creatorcontrib>Zhao, Mengya</creatorcontrib><creatorcontrib>Xu, Yan</creatorcontrib><creatorcontrib>Liang, Jiabin</creatorcontrib><creatorcontrib>Ye, Yufeng</creatorcontrib><creatorcontrib>Chen, Hanwei</creatorcontrib><title>Treatment of Gout with TCM Using Turmeric and Corn Silk: A Concise Review Article and Pharmacology Network Analysis</title><title>Evidence-based complementary and alternative medicine</title><description>Objective. This work aimed to study the compounds, targets, and pathways of turmeric and corn silk for gout and to explore the mechanism of “the same disease with different treatments” based on network pharmacology and molecular docking. Methods. We used the TCMSP, PubChem, and SEA databases to screen the compounds and targets of turmeric and corn silk, gout-related proteins through TTD, Drugbank, DisGeNET, GeneCards, OMIM, and PharmGkb, and used Cytoscape to construct a “compound-target-disease” network. Then, we constructed a protein-protein interaction network (PPI) and used Metascape to perform GO and KEGG analysis. Finally, molecular docking (SYBYL) was used to verify the degree of binding between key targets and compounds. Results. We found bisacumol, campesterol, and stigmasterol to be the main turmeric compounds that exerted a marked effect on gout treatment by targeting protein processing in the endoplasmic reticulum through the HSPA1B, HSP90AB1, and STUB1 proteins. The main corn silk compound, Mandenol, treated gout by targeting the Hippo signaling pathway through the CTNNB1, YWHAG, and YWHAZ proteins. Conclusion. Turmeric and corn silk can treat the same disease, gout, through different pathways and targets. The scientific connotation of “same disease with different treatments” can be preliminarily clarified by analyzing targets and pathways.</description><subject>Arthritis</subject><subject>Chinese medicine</subject><subject>Corn</subject><subject>Disease</subject><subject>Endoplasmic reticulum</subject><subject>Gout</subject><subject>Pharmacology</subject><subject>Protein interaction</subject><subject>Proteins</subject><subject>Rheumatism</subject><subject>Signal transduction</subject><subject>Software</subject><subject>Uric acid</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kVtLKzEQxxdR8PrmBwj4ImiPm-xlsj4IpXg8B7yhFXwL2eykje4mNdm19Nu7tUXQB59mhvnxn8s_ig5p_IfSLDtjMWNnCU0TSJKNaIdCSgcp43zzK4fn7Wg3hJc4ZgUA7ERh7FG2DdqWOE2uXNeSuWmnZDy6IU_B2AkZd75BbxSRtiIj5y15NPXrORn2hVUmIHnAd4NzMvStUTV-cvdT6RupXO0mC3KL7dz5VzK0sl4EE_ajLS3rgAfruBc9_b0cj_4Nru-u_o-G1wOVsqwdMChoXuSlqjCjWALmoAqEnEsNZVlBpgtWVlIrrrXmkCnMJecaKsx1iVma7EUXK91ZVzZYqf5IL2sx86aRfiGcNOJ7x5qpmLh3UWQ871_YCxyvBbx76zC0ojFBYV1Li64LggHjNGUsWc46-oG-uM73B39SkBYs5tBTpytKeReCR_21DI3F0kKxtFCsLezxkxU-NbaSc_M7_QFHGJ1i</recordid><startdate>20221014</startdate><enddate>20221014</enddate><creator>Zhang, Haoyu</creator><creator>Jiang, Huizhong</creator><creator>Zhao, Mengya</creator><creator>Xu, Yan</creator><creator>Liang, Jiabin</creator><creator>Ye, Yufeng</creator><creator>Chen, Hanwei</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9618-542X</orcidid><orcidid>https://orcid.org/0000-0003-0636-5302</orcidid><orcidid>https://orcid.org/0000-0002-1047-9786</orcidid><orcidid>https://orcid.org/0000-0001-5258-339X</orcidid><orcidid>https://orcid.org/0000-0002-9843-475X</orcidid></search><sort><creationdate>20221014</creationdate><title>Treatment of Gout with TCM Using Turmeric and Corn Silk: A Concise Review Article and Pharmacology Network Analysis</title><author>Zhang, Haoyu ; Jiang, Huizhong ; Zhao, Mengya ; Xu, Yan ; Liang, Jiabin ; Ye, Yufeng ; Chen, Hanwei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c425t-2791696bcde51eb7e67c9e768af7bbd75f92bdafc8fff875ce6a88f7de6fbe543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arthritis</topic><topic>Chinese medicine</topic><topic>Corn</topic><topic>Disease</topic><topic>Endoplasmic reticulum</topic><topic>Gout</topic><topic>Pharmacology</topic><topic>Protein interaction</topic><topic>Proteins</topic><topic>Rheumatism</topic><topic>Signal transduction</topic><topic>Software</topic><topic>Uric acid</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Haoyu</creatorcontrib><creatorcontrib>Jiang, Huizhong</creatorcontrib><creatorcontrib>Zhao, Mengya</creatorcontrib><creatorcontrib>Xu, Yan</creatorcontrib><creatorcontrib>Liang, Jiabin</creatorcontrib><creatorcontrib>Ye, Yufeng</creatorcontrib><creatorcontrib>Chen, Hanwei</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Haoyu</au><au>Jiang, Huizhong</au><au>Zhao, Mengya</au><au>Xu, Yan</au><au>Liang, Jiabin</au><au>Ye, Yufeng</au><au>Chen, Hanwei</au><au>El Sayed, Salah M.</au><au>Salah M El Sayed</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Treatment of Gout with TCM Using Turmeric and Corn Silk: A Concise Review Article and Pharmacology Network Analysis</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><date>2022-10-14</date><risdate>2022</risdate><volume>2022</volume><spage>1</spage><epage>18</epage><pages>1-18</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Objective. This work aimed to study the compounds, targets, and pathways of turmeric and corn silk for gout and to explore the mechanism of “the same disease with different treatments” based on network pharmacology and molecular docking. Methods. We used the TCMSP, PubChem, and SEA databases to screen the compounds and targets of turmeric and corn silk, gout-related proteins through TTD, Drugbank, DisGeNET, GeneCards, OMIM, and PharmGkb, and used Cytoscape to construct a “compound-target-disease” network. Then, we constructed a protein-protein interaction network (PPI) and used Metascape to perform GO and KEGG analysis. Finally, molecular docking (SYBYL) was used to verify the degree of binding between key targets and compounds. Results. We found bisacumol, campesterol, and stigmasterol to be the main turmeric compounds that exerted a marked effect on gout treatment by targeting protein processing in the endoplasmic reticulum through the HSPA1B, HSP90AB1, and STUB1 proteins. The main corn silk compound, Mandenol, treated gout by targeting the Hippo signaling pathway through the CTNNB1, YWHAG, and YWHAZ proteins. Conclusion. Turmeric and corn silk can treat the same disease, gout, through different pathways and targets. The scientific connotation of “same disease with different treatments” can be preliminarily clarified by analyzing targets and pathways.</abstract><cop>New York</cop><pub>Hindawi</pub><doi>10.1155/2022/3143733</doi><tpages>18</tpages><orcidid>https://orcid.org/0000-0002-9618-542X</orcidid><orcidid>https://orcid.org/0000-0003-0636-5302</orcidid><orcidid>https://orcid.org/0000-0002-1047-9786</orcidid><orcidid>https://orcid.org/0000-0001-5258-339X</orcidid><orcidid>https://orcid.org/0000-0002-9843-475X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Arthritis Chinese medicine Corn Disease Endoplasmic reticulum Gout Pharmacology Protein interaction Proteins Rheumatism Signal transduction Software Uric acid |
| title | Treatment of Gout with TCM Using Turmeric and Corn Silk: A Concise Review Article and Pharmacology Network Analysis |
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