Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households
Objectives People raised in low-socioeconomic status (SES) households are at an increased risk for physical illness in adulthood. A shift in gene expression profiles in the immune system is one biological mechanism thought to account for elevated disease susceptibility, with a frequently investigate...
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| Veröffentlicht in: | Mindfulness 2022-05, Vol.13 (5), p.1185-1196 |
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| creator | West, Taylor N. Zhou, Jieni Brantley, Mary M. Kim, Sumi L. Brantley, Jeffrey Salzberg, Sharon Cole, Steve W. Fredrickson, Barbara L. |
| description | Objectives
People raised in low-socioeconomic status (SES) households are at an increased risk for physical illness in adulthood. A shift in gene expression profiles in the immune system is one biological mechanism thought to account for elevated disease susceptibility, with a frequently investigated profile being the conserved transcriptional response to adversity (CTRA), characterized by increased expression of pro-inflammatory genes and decreased expression of antiviral and antibody-related genes.
Methods
The present study investigated, in a sample of at-risk midlife adults (
N
= 88), whether those randomized to learn loving-kindness meditation (LKM) in a 6-week workshop would show a reduction in CTRA gene expression, compared to those randomized to learn mindfulness meditation (MM). We assessed emotions daily and hypothesized positive emotions to account for the expected effect of LKM on gene expression.
Results
Results showed significant group differences from pre- to post-intervention, yet in the opposite direction as hypothesized: Participants randomized to the MM group showed significant declines in CTRA gene expression, whereas those in the LKM group showed significant increases in CTRA gene expression. Both groups showed increases over the 6 weeks in daily reports of positive emotions (
b
= .007,
p
|
| doi_str_mv | 10.1007/s12671-022-01857-z |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9585929</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2728143380</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-e65bf6f03f9d89b7614ee143a2a2c10e6a39b911bada918c92d18f3690b322483</originalsourceid><addsrcrecordid>eNp9kc9uFSEUxidGY5vaF3BhSNy4GeXADAMbk6a5tibXmNjqljDM4ZZ2Llxhpto-hk8s7a3XPwvZQM734zscvqp6DvQ1UNq9ycBEBzVlrKYg266-fVTtgxSyli1vH-_OrNurDnO-pGVxxQHE02qPC9ZJaGC_-rFwDu1EoiMffBjcPAbMmXzBlOdMlvHah1V9VZT78nkyPpQKiYEscb6K9mZCcoIByeL7JhXEF8WH4jWM3iE5GuZxyuST8RmHO2EZv9Vn0fqINoa49pacTWYqrU7jnPEijkN-Vj1xZsx4-LAfVJ_fLc6PT-vlx5P3x0fL2jZdM9Uo2t4JR7lTg1R9J6BBhIYbZpgFisJw1SuA3gxGgbSKDSAdF4r2nLFG8oPq7dZ3M_drHCyGKZlRb5Jfm3Sjo_H6byX4C72K11q1slVMFYNXDwYpfp0xT3rts8VxNAHLNJp1rHwy55IW9OU_6GWcUyjjaaZAtaqhoi0U21I2xZwTut1jgOq71PU2dV1S1_ep69ty6cWfY-yu_Mq4AHwL5CKFFabfvf9j-xN1_Ltp</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2919594065</pqid></control><display><type>article</type><title>Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households</title><source>Springer Nature - Complete Springer Journals</source><source>ProQuest Central</source><creator>West, Taylor N. ; Zhou, Jieni ; Brantley, Mary M. ; Kim, Sumi L. ; Brantley, Jeffrey ; Salzberg, Sharon ; Cole, Steve W. ; Fredrickson, Barbara L.</creator><creatorcontrib>West, Taylor N. ; Zhou, Jieni ; Brantley, Mary M. ; Kim, Sumi L. ; Brantley, Jeffrey ; Salzberg, Sharon ; Cole, Steve W. ; Fredrickson, Barbara L.</creatorcontrib><description>Objectives
People raised in low-socioeconomic status (SES) households are at an increased risk for physical illness in adulthood. A shift in gene expression profiles in the immune system is one biological mechanism thought to account for elevated disease susceptibility, with a frequently investigated profile being the conserved transcriptional response to adversity (CTRA), characterized by increased expression of pro-inflammatory genes and decreased expression of antiviral and antibody-related genes.
Methods
The present study investigated, in a sample of at-risk midlife adults (
N
= 88), whether those randomized to learn loving-kindness meditation (LKM) in a 6-week workshop would show a reduction in CTRA gene expression, compared to those randomized to learn mindfulness meditation (MM). We assessed emotions daily and hypothesized positive emotions to account for the expected effect of LKM on gene expression.
Results
Results showed significant group differences from pre- to post-intervention, yet in the opposite direction as hypothesized: Participants randomized to the MM group showed significant declines in CTRA gene expression, whereas those in the LKM group showed significant increases in CTRA gene expression. Both groups showed increases over the 6 weeks in daily reports of positive emotions (
b
= .007,
p
< .001) alongside decreases in negative emotions (
b
=
−
.005,
p
< .001). Thus, positive emotions were not pursued as a candidate mediator of observed group effects.
Conclusions
This study is the first to examine whether the biological impact of childhood low SES can be reversed in midlife through meditation interventions. Results suggest mindfulness meditation may be a viable option for improving health outcomes in this at-risk population.
Trial Registration
ClinicalTrials.gov Identifier: NCT02400593.</description><identifier>ISSN: 1868-8527</identifier><identifier>EISSN: 1868-8535</identifier><identifier>DOI: 10.1007/s12671-022-01857-z</identifier><identifier>PMID: 36278141</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Adults ; Bacterial infections ; Behavioral Science and Psychology ; Biomarkers ; Cardiovascular disease ; Child and School Psychology ; Chronic illnesses ; Cognitive Psychology ; Emotions ; Gene expression ; Households ; Hypotheses ; Inclusion ; Leukocytes ; Low income groups ; Meditation ; Middle age ; Mindfulness ; Original Paper ; Pediatrics ; Psychology ; Public Health ; Social Sciences ; Socioeconomic factors ; Socioeconomic status ; Viral infections</subject><ispartof>Mindfulness, 2022-05, Vol.13 (5), p.1185-1196</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. corrected publication 2022</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022. corrected publication 2022.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-e65bf6f03f9d89b7614ee143a2a2c10e6a39b911bada918c92d18f3690b322483</citedby><cites>FETCH-LOGICAL-c474t-e65bf6f03f9d89b7614ee143a2a2c10e6a39b911bada918c92d18f3690b322483</cites><orcidid>0000-0001-6324-4588 ; 0000-0002-3890-2646</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12671-022-01857-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2919594065?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,776,780,881,21367,27901,27902,33721,33722,41464,42533,43781,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36278141$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>West, Taylor N.</creatorcontrib><creatorcontrib>Zhou, Jieni</creatorcontrib><creatorcontrib>Brantley, Mary M.</creatorcontrib><creatorcontrib>Kim, Sumi L.</creatorcontrib><creatorcontrib>Brantley, Jeffrey</creatorcontrib><creatorcontrib>Salzberg, Sharon</creatorcontrib><creatorcontrib>Cole, Steve W.</creatorcontrib><creatorcontrib>Fredrickson, Barbara L.</creatorcontrib><title>Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households</title><title>Mindfulness</title><addtitle>Mindfulness</addtitle><addtitle>Mindfulness (N Y)</addtitle><description>Objectives
People raised in low-socioeconomic status (SES) households are at an increased risk for physical illness in adulthood. A shift in gene expression profiles in the immune system is one biological mechanism thought to account for elevated disease susceptibility, with a frequently investigated profile being the conserved transcriptional response to adversity (CTRA), characterized by increased expression of pro-inflammatory genes and decreased expression of antiviral and antibody-related genes.
Methods
The present study investigated, in a sample of at-risk midlife adults (
N
= 88), whether those randomized to learn loving-kindness meditation (LKM) in a 6-week workshop would show a reduction in CTRA gene expression, compared to those randomized to learn mindfulness meditation (MM). We assessed emotions daily and hypothesized positive emotions to account for the expected effect of LKM on gene expression.
Results
Results showed significant group differences from pre- to post-intervention, yet in the opposite direction as hypothesized: Participants randomized to the MM group showed significant declines in CTRA gene expression, whereas those in the LKM group showed significant increases in CTRA gene expression. Both groups showed increases over the 6 weeks in daily reports of positive emotions (
b
= .007,
p
< .001) alongside decreases in negative emotions (
b
=
−
.005,
p
< .001). Thus, positive emotions were not pursued as a candidate mediator of observed group effects.
Conclusions
This study is the first to examine whether the biological impact of childhood low SES can be reversed in midlife through meditation interventions. Results suggest mindfulness meditation may be a viable option for improving health outcomes in this at-risk population.
Trial Registration
ClinicalTrials.gov Identifier: NCT02400593.</description><subject>Adults</subject><subject>Bacterial infections</subject><subject>Behavioral Science and Psychology</subject><subject>Biomarkers</subject><subject>Cardiovascular disease</subject><subject>Child and School Psychology</subject><subject>Chronic illnesses</subject><subject>Cognitive Psychology</subject><subject>Emotions</subject><subject>Gene expression</subject><subject>Households</subject><subject>Hypotheses</subject><subject>Inclusion</subject><subject>Leukocytes</subject><subject>Low income groups</subject><subject>Meditation</subject><subject>Middle age</subject><subject>Mindfulness</subject><subject>Original Paper</subject><subject>Pediatrics</subject><subject>Psychology</subject><subject>Public Health</subject><subject>Social Sciences</subject><subject>Socioeconomic factors</subject><subject>Socioeconomic status</subject><subject>Viral infections</subject><issn>1868-8527</issn><issn>1868-8535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNp9kc9uFSEUxidGY5vaF3BhSNy4GeXADAMbk6a5tibXmNjqljDM4ZZ2Llxhpto-hk8s7a3XPwvZQM734zscvqp6DvQ1UNq9ycBEBzVlrKYg266-fVTtgxSyli1vH-_OrNurDnO-pGVxxQHE02qPC9ZJaGC_-rFwDu1EoiMffBjcPAbMmXzBlOdMlvHah1V9VZT78nkyPpQKiYEscb6K9mZCcoIByeL7JhXEF8WH4jWM3iE5GuZxyuST8RmHO2EZv9Vn0fqINoa49pacTWYqrU7jnPEijkN-Vj1xZsx4-LAfVJ_fLc6PT-vlx5P3x0fL2jZdM9Uo2t4JR7lTg1R9J6BBhIYbZpgFisJw1SuA3gxGgbSKDSAdF4r2nLFG8oPq7dZ3M_drHCyGKZlRb5Jfm3Sjo_H6byX4C72K11q1slVMFYNXDwYpfp0xT3rts8VxNAHLNJp1rHwy55IW9OU_6GWcUyjjaaZAtaqhoi0U21I2xZwTut1jgOq71PU2dV1S1_ep69ty6cWfY-yu_Mq4AHwL5CKFFabfvf9j-xN1_Ltp</recordid><startdate>20220501</startdate><enddate>20220501</enddate><creator>West, Taylor N.</creator><creator>Zhou, Jieni</creator><creator>Brantley, Mary M.</creator><creator>Kim, Sumi L.</creator><creator>Brantley, Jeffrey</creator><creator>Salzberg, Sharon</creator><creator>Cole, Steve W.</creator><creator>Fredrickson, Barbara L.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7WY</scope><scope>7WZ</scope><scope>7XB</scope><scope>87Z</scope><scope>8FK</scope><scope>8FL</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>BEZIV</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FRNLG</scope><scope>F~G</scope><scope>K60</scope><scope>K6~</scope><scope>L.-</scope><scope>M0C</scope><scope>PQBIZ</scope><scope>PQBZA</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>PYYUZ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6324-4588</orcidid><orcidid>https://orcid.org/0000-0002-3890-2646</orcidid></search><sort><creationdate>20220501</creationdate><title>Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households</title><author>West, Taylor N. ; Zhou, Jieni ; Brantley, Mary M. ; Kim, Sumi L. ; Brantley, Jeffrey ; Salzberg, Sharon ; Cole, Steve W. ; Fredrickson, Barbara L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-e65bf6f03f9d89b7614ee143a2a2c10e6a39b911bada918c92d18f3690b322483</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adults</topic><topic>Bacterial infections</topic><topic>Behavioral Science and Psychology</topic><topic>Biomarkers</topic><topic>Cardiovascular disease</topic><topic>Child and School Psychology</topic><topic>Chronic illnesses</topic><topic>Cognitive Psychology</topic><topic>Emotions</topic><topic>Gene expression</topic><topic>Households</topic><topic>Hypotheses</topic><topic>Inclusion</topic><topic>Leukocytes</topic><topic>Low income groups</topic><topic>Meditation</topic><topic>Middle age</topic><topic>Mindfulness</topic><topic>Original Paper</topic><topic>Pediatrics</topic><topic>Psychology</topic><topic>Public Health</topic><topic>Social Sciences</topic><topic>Socioeconomic factors</topic><topic>Socioeconomic status</topic><topic>Viral infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>West, Taylor N.</creatorcontrib><creatorcontrib>Zhou, Jieni</creatorcontrib><creatorcontrib>Brantley, Mary M.</creatorcontrib><creatorcontrib>Kim, Sumi L.</creatorcontrib><creatorcontrib>Brantley, Jeffrey</creatorcontrib><creatorcontrib>Salzberg, Sharon</creatorcontrib><creatorcontrib>Cole, Steve W.</creatorcontrib><creatorcontrib>Fredrickson, Barbara L.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ABI-INFORM Complete</collection><collection>ABI/INFORM Global (PDF only)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ABI/INFORM Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest Business Premium Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Business Premium Collection (Alumni)</collection><collection>ABI/INFORM Global (Corporate)</collection><collection>ProQuest Business Collection (Alumni Edition)</collection><collection>ProQuest Business Collection</collection><collection>ABI/INFORM Professional Advanced</collection><collection>ABI/INFORM Global</collection><collection>One Business (ProQuest)</collection><collection>ProQuest One Business (Alumni)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ABI/INFORM Collection China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Mindfulness</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>West, Taylor N.</au><au>Zhou, Jieni</au><au>Brantley, Mary M.</au><au>Kim, Sumi L.</au><au>Brantley, Jeffrey</au><au>Salzberg, Sharon</au><au>Cole, Steve W.</au><au>Fredrickson, Barbara L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households</atitle><jtitle>Mindfulness</jtitle><stitle>Mindfulness</stitle><addtitle>Mindfulness (N Y)</addtitle><date>2022-05-01</date><risdate>2022</risdate><volume>13</volume><issue>5</issue><spage>1185</spage><epage>1196</epage><pages>1185-1196</pages><issn>1868-8527</issn><eissn>1868-8535</eissn><abstract>Objectives
People raised in low-socioeconomic status (SES) households are at an increased risk for physical illness in adulthood. A shift in gene expression profiles in the immune system is one biological mechanism thought to account for elevated disease susceptibility, with a frequently investigated profile being the conserved transcriptional response to adversity (CTRA), characterized by increased expression of pro-inflammatory genes and decreased expression of antiviral and antibody-related genes.
Methods
The present study investigated, in a sample of at-risk midlife adults (
N
= 88), whether those randomized to learn loving-kindness meditation (LKM) in a 6-week workshop would show a reduction in CTRA gene expression, compared to those randomized to learn mindfulness meditation (MM). We assessed emotions daily and hypothesized positive emotions to account for the expected effect of LKM on gene expression.
Results
Results showed significant group differences from pre- to post-intervention, yet in the opposite direction as hypothesized: Participants randomized to the MM group showed significant declines in CTRA gene expression, whereas those in the LKM group showed significant increases in CTRA gene expression. Both groups showed increases over the 6 weeks in daily reports of positive emotions (
b
= .007,
p
< .001) alongside decreases in negative emotions (
b
=
−
.005,
p
< .001). Thus, positive emotions were not pursued as a candidate mediator of observed group effects.
Conclusions
This study is the first to examine whether the biological impact of childhood low SES can be reversed in midlife through meditation interventions. Results suggest mindfulness meditation may be a viable option for improving health outcomes in this at-risk population.
Trial Registration
ClinicalTrials.gov Identifier: NCT02400593.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>36278141</pmid><doi>10.1007/s12671-022-01857-z</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-6324-4588</orcidid><orcidid>https://orcid.org/0000-0002-3890-2646</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1868-8527 |
| ispartof | Mindfulness, 2022-05, Vol.13 (5), p.1185-1196 |
| issn | 1868-8527 1868-8535 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9585929 |
| source | Springer Nature - Complete Springer Journals; ProQuest Central |
| subjects | Adults Bacterial infections Behavioral Science and Psychology Biomarkers Cardiovascular disease Child and School Psychology Chronic illnesses Cognitive Psychology Emotions Gene expression Households Hypotheses Inclusion Leukocytes Low income groups Meditation Middle age Mindfulness Original Paper Pediatrics Psychology Public Health Social Sciences Socioeconomic factors Socioeconomic status Viral infections |
| title | Effect of Mindfulness Versus Loving-kindness Training on Leukocyte Gene Expression in Midlife Adults Raised in Low-Socioeconomic Status Households |
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