Computational Clues of Immunogenic Hotspots in Plasmodium falciparum Erythrocytic Stage Vaccine Candidate Antigens: In Silico Approach

Malaria is the most pernicious parasitic infection, and Plasmodium falciparum is the most virulent species with substantial morbidity and mortality worldwide. The present in silico investigation was performed to reveal the biophysical characteristics and immunogenic epitopes of the 14 blood-stage pr...

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Veröffentlicht in:	BioMed research international 2022, Vol.2022 (1), p.5886687-5886687
Hauptverfasser:	Azimi-Resketi, Mojtaba, Heydaryan, Saeed, Kumar, Niloufar, Takalou, Azin, Dizaji, Reza Esmaeelzadeh, Gorgani, Bahman Noroozi, Shams, Morteza
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergenicity Amino acids Antigenic determinants Antigenicity Antigens Causes of Computer applications Epitopes Genetic aspects Health aspects Histocompatibility antigen HLA Identification and classification Immunogenicity Immunological research Laboratory animals Localization Lymphocytes Lymphocytes B Lymphocytes T Malaria Malaria vaccine Morbidity Parasitic diseases Peptides Physicochemical properties Physiological aspects Plasmodium falciparum Proteins Servers Simulation Solubility Structural analysis Three dimensional models Transmembrane domains Vaccination Vaccines Vector-borne diseases γ-Interferon
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