Super-enhancer hypermutation alters oncogene expression in B cell lymphoma

Diffuse large B cell lymphoma (DLBCL) is the most common B cell non-Hodgkin lymphoma and remains incurable in around 40% of patients. Efforts to sequence the coding genome identified several genes and pathways that are altered in this disease, including potential therapeutic targets 1 – 5 . However,...

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Veröffentlicht in:	Nature (London) 2022-07, Vol.607 (7920), p.808-815
Hauptverfasser:	Bal, Elodie, Kumar, Rahul, Hadigol, Mohammad, Holmes, Antony B., Hilton, Laura K., Loh, Jui Wan, Dreval, Kostiantyn, Wong, Jasper C. H., Vlasevska, Sofija, Corinaldesi, Clarissa, Soni, Rajesh Kumar, Basso, Katia, Morin, Ryan D., Khiabanian, Hossein, Pasqualucci, Laura, Dalla-Favera, Riccardo
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/1 13/106 13/109 13/31 38 45/15 45/22 45/23 45/29 45/41 45/44 45/77 45/90 45/91 631/208/68 631/67/69 82 82/58 82/83 Activation-induced cytidine deaminase B-cell lymphoma Bcl-6 protein Binding CXCR4 protein Cytidine deaminase Deregulation Down-Regulation Enhancer Elements, Genetic - genetics Enhancers Gene expression Gene Expression Regulation, Neoplastic Genes Genomes Humanities and Social Sciences Humans Lymphoma Lymphoma, Large B-Cell, Diffuse - genetics Lymphoma, Large B-Cell, Diffuse - metabolism multidisciplinary Mutation Non-Hodgkin's lymphoma Nucleotide sequence Oncogenes - genetics Pathogenesis Positive Regulatory Domain I-Binding Factor 1 - metabolism Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-6 - genetics Proto-oncogenes Receptors, CXCR4 - genetics Receptors, Glucocorticoid - metabolism Repressor Proteins - metabolism Repressors Science Science (multidisciplinary) Transcription factors Tumors
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