Effective Rapid Diagnosis of Bacterial and Fungal Bloodstream Infections by T2 Magnetic Resonance Technology in the Pediatric Population
Children are prone to bloodstream infections (BSIs), the rapid and accurate diagnosis of which is an unmet clinical need. The T2MR technology is a direct molecular assay for identification of BSI pathogens, which can help to overcome the limits of blood culture (BC) such as diagnostic accuracy, bloo...
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| Veröffentlicht in: | Journal of clinical microbiology 2022-10, Vol.60 (10), p.e0029222-e0029222 |
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| creator | Lucignano, Barbara Cento, Valeria Agosta, Marilena Ambrogi, Federico Albitar-Nehme, Sami Mancinelli, Livia Mattana, Giordana Onori, Manuela Galaverna, Federica Di Chiara, Luca Fragasso, Tiziana Bianchi, Roberto Tortora, Francesca Auriti, Cinzia Dotta, Andrea Cecchetti, Corrado Perdichizzi, Salvatore Raponi, Massimiliano Onetti Muda, Andrea Nerini Molteni, Silvia Villani, Alberto Locatelli, Franco Perno, Carlo Federico Bernaschi, Paola |
| description | Children are prone to bloodstream infections (BSIs), the rapid and accurate diagnosis of which is an unmet clinical need. The T2MR technology is a direct molecular assay for identification of BSI pathogens, which can help to overcome the limits of blood culture (BC) such as diagnostic accuracy, blood volumes required, and turnaround time. We analyzed results obtained with the T2Bacteria (648) and T2Candida (106) panels in pediatric patients of the Bambino Gesù Children's Hospital between May 2018 and September 2020 in order to evaluate the performance of the T2Dx instrument with respect to BC. T2Bacteria and T2Candida panels showed 84.2% and 100% sensitivity with 85.9% and 94.1% specificity, respectively. The sensitivity and specificity of the T2Bacteria panel increased to 94.9% and 98.7%, respectively, when BC was negative but other laboratory data supported the molecular result. T2Bacteria sensitivity was 100% with blood volumes |
| doi_str_mv | 10.1128/jcm.00292-22 |
| format | Article |
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< 0.001). T2 panels rapidly and accurately enable a diagnosis of a pediatric BSI, even in children under 1 year of age and for very small blood volumes. These findings support their clinical use in life-threatening pediatric infections, where the time to diagnosis is of utmost importance, in order to improve survival and minimize the long-term sequalae of sepsis. The T2 technology could be further developed to include more bacteria and fungi species that are involved in the etiology of sepsis.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>DOI: 10.1128/jcm.00292-22</identifier><identifier>PMID: 36069557</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Bacteria ; Bacteriology ; Blood Culture - methods ; Child ; Humans ; Infant, Newborn ; Magnetic Resonance Spectroscopy - methods ; Mycoses ; Sepsis - diagnosis ; Technology</subject><ispartof>Journal of clinical microbiology, 2022-10, Vol.60 (10), p.e0029222-e0029222</ispartof><rights>Copyright © 2022 American Society for Microbiology.</rights><rights>Copyright © 2022 American Society for Microbiology. 2022 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a418t-75ec5688948dca003a54fcf9a7c67135dd7e62ba4a5cab551eeb2f45a8cbefb83</citedby><cites>FETCH-LOGICAL-a418t-75ec5688948dca003a54fcf9a7c67135dd7e62ba4a5cab551eeb2f45a8cbefb83</cites><orcidid>0000-0002-0825-5388 ; 0000-0002-6017-3232 ; 0000-0002-6472-5380 ; 0000-0001-9820-6557</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.asm.org/doi/pdf/10.1128/jcm.00292-22$$EPDF$$P50$$Gasm2$$H</linktopdf><linktohtml>$$Uhttps://journals.asm.org/doi/full/10.1128/jcm.00292-22$$EHTML$$P50$$Gasm2$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3175,27901,27902,52726,52727,52728,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36069557$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ledeboer, Nathan A.</contributor><creatorcontrib>Lucignano, Barbara</creatorcontrib><creatorcontrib>Cento, Valeria</creatorcontrib><creatorcontrib>Agosta, Marilena</creatorcontrib><creatorcontrib>Ambrogi, Federico</creatorcontrib><creatorcontrib>Albitar-Nehme, Sami</creatorcontrib><creatorcontrib>Mancinelli, Livia</creatorcontrib><creatorcontrib>Mattana, Giordana</creatorcontrib><creatorcontrib>Onori, Manuela</creatorcontrib><creatorcontrib>Galaverna, Federica</creatorcontrib><creatorcontrib>Di Chiara, Luca</creatorcontrib><creatorcontrib>Fragasso, Tiziana</creatorcontrib><creatorcontrib>Bianchi, Roberto</creatorcontrib><creatorcontrib>Tortora, Francesca</creatorcontrib><creatorcontrib>Auriti, Cinzia</creatorcontrib><creatorcontrib>Dotta, Andrea</creatorcontrib><creatorcontrib>Cecchetti, Corrado</creatorcontrib><creatorcontrib>Perdichizzi, Salvatore</creatorcontrib><creatorcontrib>Raponi, Massimiliano</creatorcontrib><creatorcontrib>Onetti Muda, Andrea</creatorcontrib><creatorcontrib>Nerini Molteni, Silvia</creatorcontrib><creatorcontrib>Villani, Alberto</creatorcontrib><creatorcontrib>Locatelli, Franco</creatorcontrib><creatorcontrib>Perno, Carlo Federico</creatorcontrib><creatorcontrib>Bernaschi, Paola</creatorcontrib><title>Effective Rapid Diagnosis of Bacterial and Fungal Bloodstream Infections by T2 Magnetic Resonance Technology in the Pediatric Population</title><title>Journal of clinical microbiology</title><addtitle>J Clin Microbiol</addtitle><addtitle>J Clin Microbiol</addtitle><description>Children are prone to bloodstream infections (BSIs), the rapid and accurate diagnosis of which is an unmet clinical need. The T2MR technology is a direct molecular assay for identification of BSI pathogens, which can help to overcome the limits of blood culture (BC) such as diagnostic accuracy, blood volumes required, and turnaround time. We analyzed results obtained with the T2Bacteria (648) and T2Candida (106) panels in pediatric patients of the Bambino Gesù Children's Hospital between May 2018 and September 2020 in order to evaluate the performance of the T2Dx instrument with respect to BC. T2Bacteria and T2Candida panels showed 84.2% and 100% sensitivity with 85.9% and 94.1% specificity, respectively. The sensitivity and specificity of the T2Bacteria panel increased to 94.9% and 98.7%, respectively, when BC was negative but other laboratory data supported the molecular result. T2Bacteria sensitivity was 100% with blood volumes <2 mL in neonates and infants. T2Bacteria and T2Candida provided definitive microorganism identification in a mean time of 4.4 and 3.7 h, respectively, versus 65.7 and 125.5 h for BCs (
< 0.001). T2 panels rapidly and accurately enable a diagnosis of a pediatric BSI, even in children under 1 year of age and for very small blood volumes. These findings support their clinical use in life-threatening pediatric infections, where the time to diagnosis is of utmost importance, in order to improve survival and minimize the long-term sequalae of sepsis. The T2 technology could be further developed to include more bacteria and fungi species that are involved in the etiology of sepsis.</description><subject>Bacteria</subject><subject>Bacteriology</subject><subject>Blood Culture - methods</subject><subject>Child</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Mycoses</subject><subject>Sepsis - diagnosis</subject><subject>Technology</subject><issn>0095-1137</issn><issn>1098-660X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kUFrFDEYhoModlu9eZYcFZyaZCaTmYtga6uFiqWs4C18k_lmN8tMsk0yhf0H_dmm3Vr04CmBPN8Tvvcl5A1nx5yL5uPGTMeMiVYUQjwjC87apqhr9us5WTDWyoLzUh2Qwxg3jPGqkvIlOShrVrdSqgW5OxsGNMneIr2Gre3pFwsr56ON1A_0BEzCYGGk4Hp6PrtVvp6M3vcxBYSJXriHae8i7XZ0Kej3PI3JGnqN0TtwBukSzdr50a921Dqa1kivsLeQQqau_HYe4V7wirwYYIz4-vE8Ij_Pz5an34rLH18vTj9fFlDxJhVKopF107RV0xtgrARZDWZoQZla8VL2vcJadFCBNNBJyRE7MVQSGtPh0DXlEfm0927nbsLeoEsBRr0NdoKw0x6s_vfF2bVe-VvdyoaVlcqCd4-C4G9mjElPNhocR3Do56iFyonn4FWV0Q971AQfY8Dh6RvO9H15OpenH8rTQmT8_R6HOAm98XNwOYn_sW__XuNJ_KfZ8jdoGaZa</recordid><startdate>20221019</startdate><enddate>20221019</enddate><creator>Lucignano, Barbara</creator><creator>Cento, Valeria</creator><creator>Agosta, Marilena</creator><creator>Ambrogi, Federico</creator><creator>Albitar-Nehme, Sami</creator><creator>Mancinelli, Livia</creator><creator>Mattana, Giordana</creator><creator>Onori, Manuela</creator><creator>Galaverna, Federica</creator><creator>Di Chiara, Luca</creator><creator>Fragasso, Tiziana</creator><creator>Bianchi, Roberto</creator><creator>Tortora, Francesca</creator><creator>Auriti, Cinzia</creator><creator>Dotta, Andrea</creator><creator>Cecchetti, Corrado</creator><creator>Perdichizzi, Salvatore</creator><creator>Raponi, Massimiliano</creator><creator>Onetti Muda, Andrea</creator><creator>Nerini Molteni, Silvia</creator><creator>Villani, Alberto</creator><creator>Locatelli, Franco</creator><creator>Perno, Carlo Federico</creator><creator>Bernaschi, Paola</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-0825-5388</orcidid><orcidid>https://orcid.org/0000-0002-6017-3232</orcidid><orcidid>https://orcid.org/0000-0002-6472-5380</orcidid><orcidid>https://orcid.org/0000-0001-9820-6557</orcidid></search><sort><creationdate>20221019</creationdate><title>Effective Rapid Diagnosis of Bacterial and Fungal Bloodstream Infections by T2 Magnetic Resonance Technology in the Pediatric Population</title><author>Lucignano, Barbara ; Cento, Valeria ; Agosta, Marilena ; Ambrogi, Federico ; Albitar-Nehme, Sami ; Mancinelli, Livia ; Mattana, Giordana ; Onori, Manuela ; Galaverna, Federica ; Di Chiara, Luca ; Fragasso, Tiziana ; Bianchi, Roberto ; Tortora, Francesca ; Auriti, Cinzia ; Dotta, Andrea ; Cecchetti, Corrado ; Perdichizzi, Salvatore ; Raponi, Massimiliano ; Onetti Muda, Andrea ; Nerini Molteni, Silvia ; Villani, Alberto ; Locatelli, Franco ; Perno, Carlo Federico ; Bernaschi, Paola</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a418t-75ec5688948dca003a54fcf9a7c67135dd7e62ba4a5cab551eeb2f45a8cbefb83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Bacteria</topic><topic>Bacteriology</topic><topic>Blood Culture - methods</topic><topic>Child</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Magnetic Resonance Spectroscopy - methods</topic><topic>Mycoses</topic><topic>Sepsis - diagnosis</topic><topic>Technology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lucignano, Barbara</creatorcontrib><creatorcontrib>Cento, Valeria</creatorcontrib><creatorcontrib>Agosta, Marilena</creatorcontrib><creatorcontrib>Ambrogi, Federico</creatorcontrib><creatorcontrib>Albitar-Nehme, Sami</creatorcontrib><creatorcontrib>Mancinelli, Livia</creatorcontrib><creatorcontrib>Mattana, Giordana</creatorcontrib><creatorcontrib>Onori, Manuela</creatorcontrib><creatorcontrib>Galaverna, Federica</creatorcontrib><creatorcontrib>Di Chiara, Luca</creatorcontrib><creatorcontrib>Fragasso, Tiziana</creatorcontrib><creatorcontrib>Bianchi, Roberto</creatorcontrib><creatorcontrib>Tortora, Francesca</creatorcontrib><creatorcontrib>Auriti, Cinzia</creatorcontrib><creatorcontrib>Dotta, Andrea</creatorcontrib><creatorcontrib>Cecchetti, Corrado</creatorcontrib><creatorcontrib>Perdichizzi, Salvatore</creatorcontrib><creatorcontrib>Raponi, Massimiliano</creatorcontrib><creatorcontrib>Onetti Muda, Andrea</creatorcontrib><creatorcontrib>Nerini Molteni, Silvia</creatorcontrib><creatorcontrib>Villani, Alberto</creatorcontrib><creatorcontrib>Locatelli, Franco</creatorcontrib><creatorcontrib>Perno, Carlo Federico</creatorcontrib><creatorcontrib>Bernaschi, Paola</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lucignano, Barbara</au><au>Cento, Valeria</au><au>Agosta, Marilena</au><au>Ambrogi, Federico</au><au>Albitar-Nehme, Sami</au><au>Mancinelli, Livia</au><au>Mattana, Giordana</au><au>Onori, Manuela</au><au>Galaverna, Federica</au><au>Di Chiara, Luca</au><au>Fragasso, Tiziana</au><au>Bianchi, Roberto</au><au>Tortora, Francesca</au><au>Auriti, Cinzia</au><au>Dotta, Andrea</au><au>Cecchetti, Corrado</au><au>Perdichizzi, Salvatore</au><au>Raponi, Massimiliano</au><au>Onetti Muda, Andrea</au><au>Nerini Molteni, Silvia</au><au>Villani, Alberto</au><au>Locatelli, Franco</au><au>Perno, Carlo Federico</au><au>Bernaschi, Paola</au><au>Ledeboer, Nathan A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effective Rapid Diagnosis of Bacterial and Fungal Bloodstream Infections by T2 Magnetic Resonance Technology in the Pediatric Population</atitle><jtitle>Journal of clinical microbiology</jtitle><stitle>J Clin Microbiol</stitle><addtitle>J Clin Microbiol</addtitle><date>2022-10-19</date><risdate>2022</risdate><volume>60</volume><issue>10</issue><spage>e0029222</spage><epage>e0029222</epage><pages>e0029222-e0029222</pages><issn>0095-1137</issn><eissn>1098-660X</eissn><abstract>Children are prone to bloodstream infections (BSIs), the rapid and accurate diagnosis of which is an unmet clinical need. The T2MR technology is a direct molecular assay for identification of BSI pathogens, which can help to overcome the limits of blood culture (BC) such as diagnostic accuracy, blood volumes required, and turnaround time. We analyzed results obtained with the T2Bacteria (648) and T2Candida (106) panels in pediatric patients of the Bambino Gesù Children's Hospital between May 2018 and September 2020 in order to evaluate the performance of the T2Dx instrument with respect to BC. T2Bacteria and T2Candida panels showed 84.2% and 100% sensitivity with 85.9% and 94.1% specificity, respectively. The sensitivity and specificity of the T2Bacteria panel increased to 94.9% and 98.7%, respectively, when BC was negative but other laboratory data supported the molecular result. T2Bacteria sensitivity was 100% with blood volumes <2 mL in neonates and infants. T2Bacteria and T2Candida provided definitive microorganism identification in a mean time of 4.4 and 3.7 h, respectively, versus 65.7 and 125.5 h for BCs (
< 0.001). T2 panels rapidly and accurately enable a diagnosis of a pediatric BSI, even in children under 1 year of age and for very small blood volumes. These findings support their clinical use in life-threatening pediatric infections, where the time to diagnosis is of utmost importance, in order to improve survival and minimize the long-term sequalae of sepsis. The T2 technology could be further developed to include more bacteria and fungi species that are involved in the etiology of sepsis.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>36069557</pmid><doi>10.1128/jcm.00292-22</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-0825-5388</orcidid><orcidid>https://orcid.org/0000-0002-6017-3232</orcidid><orcidid>https://orcid.org/0000-0002-6472-5380</orcidid><orcidid>https://orcid.org/0000-0001-9820-6557</orcidid><oa>free_for_read</oa></addata></record> |
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| source | American Society for Microbiology; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Bacteria Bacteriology Blood Culture - methods Child Humans Infant, Newborn Magnetic Resonance Spectroscopy - methods Mycoses Sepsis - diagnosis Technology |
| title | Effective Rapid Diagnosis of Bacterial and Fungal Bloodstream Infections by T2 Magnetic Resonance Technology in the Pediatric Population |
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