A Systems-Based Analysis of Mono- and Combination Therapy for Carbapenem-Resistant Klebsiella pneumoniae Bloodstream Infections

Antimicrobial resistance is a global threat. As “proof-of-concept,” we employed a system-based approach to identify patient, bacterial, and drug variables contributing to mortality in patients with carbapenem-resistant Klebsiella pneumoniae (CRKp) bloodstream infections exposed to colistin (COL) and...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2022-10, Vol.66 (10), p.e0059122-e0059122
Hauptverfasser:	Luterbach, Courtney L., Qiu, Hongqiang, Hanafin, Patrick O., Sharma, Rajnikant, Piscitelli, Joseph, Lin, Feng-Chang, Ilomaki, Jenni, Cober, Eric, Salata, Robert A., Kalayjian, Robert C., Watkins, Richard R., Doi, Yohei, Kaye, Keith S., Nation, Roger L., Bonomo, Robert A., Landersdorfer, Cornelia B., van Duin, David, Rao, Gauri G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Pharmacology Systems Biology
Online-Zugang:	Volltext
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