Radiolabeled Aminopyrazoles as Novel Isoform Selective Probes for pJNK3 Quantification

The c-Jun N-terminal kinase 3 (JNK3) is a stress-activated kinase primarily expressed in the brain and implicated as an early mediator of neuronal apoptosis. We sought to develop a PET tracer to visualize pathological JNK3 activation. Because regional JNK3 activation precedes apoptosis, such an imag...

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Veröffentlicht in:	ACS medicinal chemistry letters 2022-10, Vol.13 (10), p.1606-1614
Hauptverfasser:	Bales, Brian C., Cotero, Victoria, Meyer, Dan E., Roberts, Jeannette C., Rodriguez-Silva, Monica, Siclovan, Tiberiu M., Chambers, Jeremy W., Rishel, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Letter
Online-Zugang:	Volltext
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