Chitosan Nanoparticles: A Versatile Platform for Biomedical Applications
Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food and Drug Administration has approved chitosan for wound treatment and nutritional use. Furthermore, chitosan has paved the way for advancements in different biomedical applica...
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| Veröffentlicht in: | Materials 2022-09, Vol.15 (19), p.6521 |
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| creator | Bashir, Showkeen Muzamil Ahmed Rather, Gulzar Patrício, Ana Haq, Zulfiqar Sheikh, Amir Amin Shah, Mohd Zahoor ul Haq Singh, Hemant Khan, Azmat Alam Imtiyaz, Sofi Ahmad, Sheikh Bilal Nabi, Showket Rakhshan, Rabia Hassan, Saqib Fonte, Pedro |
| description | Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food and Drug Administration has approved chitosan for wound treatment and nutritional use. Furthermore, chitosan has paved the way for advancements in different biomedical applications including as a nanocarrier and tissue-engineering scaffold. Its antibacterial, antioxidant, and haemostatic properties make it an excellent option for wound dressings. Because of its hydrophilic nature, chitosan is an ideal starting material for biocompatible and biodegradable hydrogels. To suit specific application demands, chitosan can be combined with fillers, such as hydroxyapatite, to modify the mechanical characteristics of pH-sensitive hydrogels. Furthermore, the cationic characteristics of chitosan have made it a popular choice for gene delivery and cancer therapy. Thus, the use of chitosan nanoparticles in developing novel drug delivery systems has received special attention. This review aims to provide an overview of chitosan-based nanoparticles, focusing on their versatile properties and different applications in biomedical sciences and engineering. |
| doi_str_mv | 10.3390/ma15196521 |
| format | Article |
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The Food and Drug Administration has approved chitosan for wound treatment and nutritional use. Furthermore, chitosan has paved the way for advancements in different biomedical applications including as a nanocarrier and tissue-engineering scaffold. Its antibacterial, antioxidant, and haemostatic properties make it an excellent option for wound dressings. Because of its hydrophilic nature, chitosan is an ideal starting material for biocompatible and biodegradable hydrogels. To suit specific application demands, chitosan can be combined with fillers, such as hydroxyapatite, to modify the mechanical characteristics of pH-sensitive hydrogels. Furthermore, the cationic characteristics of chitosan have made it a popular choice for gene delivery and cancer therapy. Thus, the use of chitosan nanoparticles in developing novel drug delivery systems has received special attention. This review aims to provide an overview of chitosan-based nanoparticles, focusing on their versatile properties and different applications in biomedical sciences and engineering.</description><identifier>ISSN: 1996-1944</identifier><identifier>EISSN: 1996-1944</identifier><identifier>DOI: 10.3390/ma15196521</identifier><identifier>PMID: 36233864</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Bacteria ; Biocompatibility ; Biodegradability ; Biomedical engineering ; Biomedical materials ; Bones ; Cancer ; Cellulose ; Chitosan ; Drug approval ; Drug delivery systems ; Drugs ; Free radicals ; Gram-positive bacteria ; Hydrogels ; Hydroxyapatite ; Mechanical properties ; Nanoparticles ; Natural polymers ; Polymers ; Review ; Technology application ; Tissue engineering ; Vehicles ; Wound healing</subject><ispartof>Materials, 2022-09, Vol.15 (19), p.6521</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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This review aims to provide an overview of chitosan-based nanoparticles, focusing on their versatile properties and different applications in biomedical sciences and engineering.</description><subject>Bacteria</subject><subject>Biocompatibility</subject><subject>Biodegradability</subject><subject>Biomedical engineering</subject><subject>Biomedical materials</subject><subject>Bones</subject><subject>Cancer</subject><subject>Cellulose</subject><subject>Chitosan</subject><subject>Drug approval</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Free radicals</subject><subject>Gram-positive bacteria</subject><subject>Hydrogels</subject><subject>Hydroxyapatite</subject><subject>Mechanical properties</subject><subject>Nanoparticles</subject><subject>Natural polymers</subject><subject>Polymers</subject><subject>Review</subject><subject>Technology application</subject><subject>Tissue engineering</subject><subject>Vehicles</subject><subject>Wound healing</subject><issn>1996-1944</issn><issn>1996-1944</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNptkU1LAzEQhoMoWmov_oIFLyK05ms3Gw9CLWoFUQ_qNaTZbJuSTdZkK_jvTWmxKiaQDOSZ983MAHCC4IgQDi8aiXLEixyjPdBDnBdDxCnd_xEfgUGMS5gWIajE_BAckQITUha0B6aThel8lC57lM63MnRGWR0vs3H2pkOUnbE6e7ayq31osnRk18Y3ujJK2mzctjYFnfEuHoODWtqoB9u7D15vb14m0-HD0939ZPwwVJSV3VAyzWcQM8p4NaOpAqIKqjSuZwXVVcUYIphSWTLGiFIFQwWFssaVQooRCjHpg6uNbruapX8o7bogrWiDaWT4FF4a8fvFmYWY-w_BcwYZhkngbCsQ_PtKx040JiptrXTar6LADKeG5sk_oad_0KVfBZfKW1MUJyRHO2ourRbG1T75qrWoGDOaM8JLsrYd_UOlXenGKO90nTr9O-F8k6CCjzHo-rtGBMV69GI3evIFxGCc1g</recordid><startdate>20220920</startdate><enddate>20220920</enddate><creator>Bashir, Showkeen Muzamil</creator><creator>Ahmed Rather, Gulzar</creator><creator>Patrício, Ana</creator><creator>Haq, Zulfiqar</creator><creator>Sheikh, Amir Amin</creator><creator>Shah, Mohd Zahoor ul Haq</creator><creator>Singh, Hemant</creator><creator>Khan, Azmat Alam</creator><creator>Imtiyaz, Sofi</creator><creator>Ahmad, Sheikh Bilal</creator><creator>Nabi, Showket</creator><creator>Rakhshan, Rabia</creator><creator>Hassan, Saqib</creator><creator>Fonte, Pedro</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-1115-9282</orcidid></search><sort><creationdate>20220920</creationdate><title>Chitosan Nanoparticles: A Versatile Platform for Biomedical Applications</title><author>Bashir, Showkeen Muzamil ; 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| source | MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Bacteria Biocompatibility Biodegradability Biomedical engineering Biomedical materials Bones Cancer Cellulose Chitosan Drug approval Drug delivery systems Drugs Free radicals Gram-positive bacteria Hydrogels Hydroxyapatite Mechanical properties Nanoparticles Natural polymers Polymers Review Technology application Tissue engineering Vehicles Wound healing |
| title | Chitosan Nanoparticles: A Versatile Platform for Biomedical Applications |
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