Proteomic, Transcriptomic, Mutational, and Functional Assays Reveal the Involvement of Both THF and PLP Sites at the GmSHMT08 in Resistance to Soybean Cyst Nematode

The serine hydroxymethyltransferase (SHMT; E.C. 2.1.2.1) is involved in the interconversion of serine/glycine and tetrahydrofolate (THF)/5,10-methylene THF, playing a key role in one-carbon metabolism, the de novo purine pathway, cellular methylation reactions, redox homeostasis maintenance, and met...

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Veröffentlicht in:	International journal of molecular sciences 2022-09, Vol.23 (19), p.11278
Hauptverfasser:	Lakhssassi, Naoufal, Knizia, Dounya, El Baze, Abdelhalim, Lakhssassi, Aicha, Meksem, Jonas, Meksem, Khalid
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Binding sites Biosynthesis Carbon Catalysis Cultivars Cysts Enzymes Gene expression Glycine Glycine - metabolism Glycine Hydroxymethyltransferase - chemistry Glycine max - metabolism Glycolysis Glyoxylate cycle Glyoxylates Heme Heterodera glycines Homeostasis Infections Mass spectrometry Metabolism Metabolites Methionine Methionine - genetics Mutagenesis Mutation Nematoda - genetics Nematodes Peptides Pest resistance Plant Diseases - genetics Proteins Proteomics Purines Pyridoxal Phosphate - metabolism Scientific imaging Serine Serine - genetics Signal transduction Soybeans Tetrahydrofolates - genetics Tetrahydrofolates - metabolism Tetrahydrofolic acid Transcriptome Transcriptomics
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