Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification

The neglected tropical disease leishmaniasis, caused by Leishmania spp., is becoming more problematic due to the emergence of drug-resistant strains. Therefore, new drugs to treat leishmaniasis, with novel mechanisms of action, are urgently required. Strathclyde minor groove binders (S-MGBs) are an...

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Veröffentlicht in:	International journal of molecular sciences 2022-10, Vol.23 (19), p.11912
Hauptverfasser:	Perieteanu, Marina C, McGee, Leah M C, Shaw, Craig D, MacMillan, Donna S, Khalaf, Abedawn I, Gillingwater, Kirsten, Beveridge, Rebecca, Carter, Katharine C, Suckling, Colin J, Scott, Fraser J
Format:	Artikel
Sprache:	eng
Schlagworte:	Amines Antiinfectives and antibacterials Bacteria Derivation DNA - metabolism Drug resistance Gram-positive bacteria Grooves Hydrogenation Infections Leishmania - metabolism Leishmaniasis Oxides Parasites Parasitic diseases Public health Tropical diseases
Online-Zugang:	Volltext
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