A Fine Regulation of the Hippocampal Thyroid Signalling Protects Hypothyroid Mice against Glial Cell Activation

Adult-onset hypothyroidism is associated with learning and cognitive dysfunctions, which may be related to alterations in synaptic plasticity. Local reduced levels of thyroid hormones (THs) may impair glia morphology and activity, and promote the increase of pro-inflammatory cytokine levels mainly i...

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Veröffentlicht in:	International journal of molecular sciences 2022-10, Vol.23 (19), p.11938
Hauptverfasser:	Chamas, Lamis, Seugnet, Isabelle, Poirier, Roseline, Clerget-Froidevaux, Marie-Stéphanie, Enderlin, Valérie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Cell activation Cytokines Endocrinology and metabolism Gene expression Glial cells High fat diet Hippocampus Human health and pathology Hypothyroidism Inflammation Life Sciences Male Memory Mice Mice, Inbred C57BL Neurobiology Neuroglia Neuronal-glial interactions Neurons and Cognition Obesity Propylthiouracil Rodents Synaptic plasticity Thyroid gland Thyroid Hormones Weight control
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