CircCRIM1 Ameliorates Endothelial Cell Angiogenesis in Aging through the miR-455-3p/Twist1/VEGFR2 Signaling Axis

Background. Aging leads to vascular endothelial cell senescence. Decreased expression of VEGFA and VEGFR2 plays a crucial role in impairing angiogenesis in senescent endothelial cells. Noncoding RNAs, including circular RNAs (circRNAs) and microRNAs (miRNAs), regulate endothelial cell proliferation,...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2022-10, Vol.2022, p.1-14
Hauptverfasser:	Zhao, Lei, Chen, Rencong, Qiu, Jiacong, Huang, Yingxiong, Lian, Chong, Zhu, Xiaonan, Cui, Jin, Wang, Siwen, Wang, Shenming, Hu, Zuojun, Wang, Jinsong
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Angiogenesis Antibodies Binding sites Epigenetics Experiments Gene expression Homeostasis MicroRNAs Mutation Proteins
Online-Zugang:	Volltext
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