Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward

The challenge to explain the diffuse and unconclusive message reported by hyperthermia studies investigating the thermal dose parameter is still to be unravelled. In the present review, we investigated a wide range of technical and clinical parameters characterising hyperthermia treatment to better...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Cancers 2022-09, Vol.14 (19), p.4795
Hauptverfasser: Carrapiço-Seabra, Carolina, Curto, Sergio, Franckena, Martine, Rhoon, Gerard C. Van
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 19
container_start_page 4795
container_title Cancers
container_volume 14
creator Carrapiço-Seabra, Carolina
Curto, Sergio
Franckena, Martine
Rhoon, Gerard C. Van
description The challenge to explain the diffuse and unconclusive message reported by hyperthermia studies investigating the thermal dose parameter is still to be unravelled. In the present review, we investigated a wide range of technical and clinical parameters characterising hyperthermia treatment to better understand and improve the probability of detecting a thermal dose effect relationship in clinical studies. We performed a systematic literature review to obtain hyperthermia clinical studies investigating the associations of temperature and thermal dose parameters with treatment outcome or acute toxicity. Different hyperthermia characteristics were retrieved, and their influence on temperature and thermal dose parameters was assessed. In the literature, we found forty-eight articles investigating thermal dose effect relationships. These comprised a total of 4107 patients with different tumour pathologies. The association between thermal dose and treatment outcome was the investigated endpoint in 90% of the articles, while the correlation between thermal dose and toxicity was investigated in 50% of the articles. Significant associations between temperature-related parameters and treatment outcome were reported in 63% of the studies, while those between temperature-related parameters and toxicity were reported in 15% of the studies. One clear difficulty for advancement is that studies often omitted fundamental information regarding the clinical treatment, and among the different characteristics investigated, thermometry details were seldom and divergently reported. To overcome this, we propose a clear definition of the terms and characteristics that should be reported in clinical hyperthermia treatments. A consistent report of data will allow their use to further continue the quest for thermal dose effect relationships.
doi_str_mv 10.3390/cancers14194795
format Article
fullrecord <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9562191</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A745271863</galeid><sourcerecordid>A745271863</sourcerecordid><originalsourceid>FETCH-LOGICAL-c465t-3e19cc7d4bab828ce70644c876b61860814ce49f86e2d37c475cf51931fdd40b3</originalsourceid><addsrcrecordid>eNptkk1rHDEMhofS0oQ0514NvfSyib_GHvdQWNJ8QaAhTQ89GY8t7zrM2Ft7ZkP_fbwkpE2ofJCQH73iBTXNR4KPGFP42JpoIRfCieJStW-afYolXQih-Nt_6r3msJQ7XIMxIoV83-wxQRmWRO43v5bbFFyIK3QdJm-GoaAQ0e0a8mgG9C0VQKfeg53QDQxmCimWddigH9PsApQvaFn72wD3yESHzufgAJ2lfG-y-9C8q3oFDp_yQfPz7PT25GJx9f388mR5tbBctNOCAVHWSsd703e0syCx4Nx2UvSCdAJ3hFvgyncCqGPSctla3xLFiHeO454dNF8fdTdzP4KzEKdsBr3JYTT5j04m6Jc_Maz1Km21agUlilSBz08COf2eoUx6DMXCMJgIaS6aSrrbJ0Vb0U-v0Ls051jt7ShOqWqx-EutzAA6RJ_qXrsT1UvJWyqrL1apo_9Q9TkYg00RfKj9FwPHjwM2p1Iy-GePBOvdQehXB8EeAIM8prE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2724229506</pqid></control><display><type>article</type><title>Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward</title><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Carrapiço-Seabra, Carolina ; Curto, Sergio ; Franckena, Martine ; Rhoon, Gerard C. Van</creator><creatorcontrib>Carrapiço-Seabra, Carolina ; Curto, Sergio ; Franckena, Martine ; Rhoon, Gerard C. Van</creatorcontrib><description>The challenge to explain the diffuse and unconclusive message reported by hyperthermia studies investigating the thermal dose parameter is still to be unravelled. In the present review, we investigated a wide range of technical and clinical parameters characterising hyperthermia treatment to better understand and improve the probability of detecting a thermal dose effect relationship in clinical studies. We performed a systematic literature review to obtain hyperthermia clinical studies investigating the associations of temperature and thermal dose parameters with treatment outcome or acute toxicity. Different hyperthermia characteristics were retrieved, and their influence on temperature and thermal dose parameters was assessed. In the literature, we found forty-eight articles investigating thermal dose effect relationships. These comprised a total of 4107 patients with different tumour pathologies. The association between thermal dose and treatment outcome was the investigated endpoint in 90% of the articles, while the correlation between thermal dose and toxicity was investigated in 50% of the articles. Significant associations between temperature-related parameters and treatment outcome were reported in 63% of the studies, while those between temperature-related parameters and toxicity were reported in 15% of the studies. One clear difficulty for advancement is that studies often omitted fundamental information regarding the clinical treatment, and among the different characteristics investigated, thermometry details were seldom and divergently reported. To overcome this, we propose a clear definition of the terms and characteristics that should be reported in clinical hyperthermia treatments. A consistent report of data will allow their use to further continue the quest for thermal dose effect relationships.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14194795</identifier><identifier>PMID: 36230717</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Acute toxicity ; Cancer ; Care and treatment ; Chemotherapy ; Clinical outcomes ; Cytotoxicity ; Dose-response relationship (Biochemistry) ; Fever ; Hyperthermia ; Literature reviews ; Medical prognosis ; Methods ; Oncology, Experimental ; Patients ; Quality control ; Systematic Review ; Temperature ; Thermotherapy ; Tumors</subject><ispartof>Cancers, 2022-09, Vol.14 (19), p.4795</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c465t-3e19cc7d4bab828ce70644c876b61860814ce49f86e2d37c475cf51931fdd40b3</citedby><cites>FETCH-LOGICAL-c465t-3e19cc7d4bab828ce70644c876b61860814ce49f86e2d37c475cf51931fdd40b3</cites><orcidid>0000-0002-3073-1117 ; 0000-0002-7365-5783</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562191/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9562191/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,53790,53792</link.rule.ids></links><search><creatorcontrib>Carrapiço-Seabra, Carolina</creatorcontrib><creatorcontrib>Curto, Sergio</creatorcontrib><creatorcontrib>Franckena, Martine</creatorcontrib><creatorcontrib>Rhoon, Gerard C. Van</creatorcontrib><title>Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward</title><title>Cancers</title><description>The challenge to explain the diffuse and unconclusive message reported by hyperthermia studies investigating the thermal dose parameter is still to be unravelled. In the present review, we investigated a wide range of technical and clinical parameters characterising hyperthermia treatment to better understand and improve the probability of detecting a thermal dose effect relationship in clinical studies. We performed a systematic literature review to obtain hyperthermia clinical studies investigating the associations of temperature and thermal dose parameters with treatment outcome or acute toxicity. Different hyperthermia characteristics were retrieved, and their influence on temperature and thermal dose parameters was assessed. In the literature, we found forty-eight articles investigating thermal dose effect relationships. These comprised a total of 4107 patients with different tumour pathologies. The association between thermal dose and treatment outcome was the investigated endpoint in 90% of the articles, while the correlation between thermal dose and toxicity was investigated in 50% of the articles. Significant associations between temperature-related parameters and treatment outcome were reported in 63% of the studies, while those between temperature-related parameters and toxicity were reported in 15% of the studies. One clear difficulty for advancement is that studies often omitted fundamental information regarding the clinical treatment, and among the different characteristics investigated, thermometry details were seldom and divergently reported. To overcome this, we propose a clear definition of the terms and characteristics that should be reported in clinical hyperthermia treatments. A consistent report of data will allow their use to further continue the quest for thermal dose effect relationships.</description><subject>Acute toxicity</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Cytotoxicity</subject><subject>Dose-response relationship (Biochemistry)</subject><subject>Fever</subject><subject>Hyperthermia</subject><subject>Literature reviews</subject><subject>Medical prognosis</subject><subject>Methods</subject><subject>Oncology, Experimental</subject><subject>Patients</subject><subject>Quality control</subject><subject>Systematic Review</subject><subject>Temperature</subject><subject>Thermotherapy</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1rHDEMhofS0oQ0514NvfSyib_GHvdQWNJ8QaAhTQ89GY8t7zrM2Ft7ZkP_fbwkpE2ofJCQH73iBTXNR4KPGFP42JpoIRfCieJStW-afYolXQih-Nt_6r3msJQ7XIMxIoV83-wxQRmWRO43v5bbFFyIK3QdJm-GoaAQ0e0a8mgG9C0VQKfeg53QDQxmCimWddigH9PsApQvaFn72wD3yESHzufgAJ2lfG-y-9C8q3oFDp_yQfPz7PT25GJx9f388mR5tbBctNOCAVHWSsd703e0syCx4Nx2UvSCdAJ3hFvgyncCqGPSctla3xLFiHeO454dNF8fdTdzP4KzEKdsBr3JYTT5j04m6Jc_Maz1Km21agUlilSBz08COf2eoUx6DMXCMJgIaS6aSrrbJ0Vb0U-v0Ls051jt7ShOqWqx-EutzAA6RJ_qXrsT1UvJWyqrL1apo_9Q9TkYg00RfKj9FwPHjwM2p1Iy-GePBOvdQehXB8EeAIM8prE</recordid><startdate>20220930</startdate><enddate>20220930</enddate><creator>Carrapiço-Seabra, Carolina</creator><creator>Curto, Sergio</creator><creator>Franckena, Martine</creator><creator>Rhoon, Gerard C. Van</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7TO</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2O</scope><scope>M7P</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3073-1117</orcidid><orcidid>https://orcid.org/0000-0002-7365-5783</orcidid></search><sort><creationdate>20220930</creationdate><title>Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward</title><author>Carrapiço-Seabra, Carolina ; Curto, Sergio ; Franckena, Martine ; Rhoon, Gerard C. Van</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c465t-3e19cc7d4bab828ce70644c876b61860814ce49f86e2d37c475cf51931fdd40b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acute toxicity</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Chemotherapy</topic><topic>Clinical outcomes</topic><topic>Cytotoxicity</topic><topic>Dose-response relationship (Biochemistry)</topic><topic>Fever</topic><topic>Hyperthermia</topic><topic>Literature reviews</topic><topic>Medical prognosis</topic><topic>Methods</topic><topic>Oncology, Experimental</topic><topic>Patients</topic><topic>Quality control</topic><topic>Systematic Review</topic><topic>Temperature</topic><topic>Thermotherapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carrapiço-Seabra, Carolina</creatorcontrib><creatorcontrib>Curto, Sergio</creatorcontrib><creatorcontrib>Franckena, Martine</creatorcontrib><creatorcontrib>Rhoon, Gerard C. Van</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Biological Science Collection</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Cancers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carrapiço-Seabra, Carolina</au><au>Curto, Sergio</au><au>Franckena, Martine</au><au>Rhoon, Gerard C. Van</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward</atitle><jtitle>Cancers</jtitle><date>2022-09-30</date><risdate>2022</risdate><volume>14</volume><issue>19</issue><spage>4795</spage><pages>4795-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>The challenge to explain the diffuse and unconclusive message reported by hyperthermia studies investigating the thermal dose parameter is still to be unravelled. In the present review, we investigated a wide range of technical and clinical parameters characterising hyperthermia treatment to better understand and improve the probability of detecting a thermal dose effect relationship in clinical studies. We performed a systematic literature review to obtain hyperthermia clinical studies investigating the associations of temperature and thermal dose parameters with treatment outcome or acute toxicity. Different hyperthermia characteristics were retrieved, and their influence on temperature and thermal dose parameters was assessed. In the literature, we found forty-eight articles investigating thermal dose effect relationships. These comprised a total of 4107 patients with different tumour pathologies. The association between thermal dose and treatment outcome was the investigated endpoint in 90% of the articles, while the correlation between thermal dose and toxicity was investigated in 50% of the articles. Significant associations between temperature-related parameters and treatment outcome were reported in 63% of the studies, while those between temperature-related parameters and toxicity were reported in 15% of the studies. One clear difficulty for advancement is that studies often omitted fundamental information regarding the clinical treatment, and among the different characteristics investigated, thermometry details were seldom and divergently reported. To overcome this, we propose a clear definition of the terms and characteristics that should be reported in clinical hyperthermia treatments. A consistent report of data will allow their use to further continue the quest for thermal dose effect relationships.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>36230717</pmid><doi>10.3390/cancers14194795</doi><orcidid>https://orcid.org/0000-0002-3073-1117</orcidid><orcidid>https://orcid.org/0000-0002-7365-5783</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2072-6694
ispartof Cancers, 2022-09, Vol.14 (19), p.4795
issn 2072-6694
2072-6694
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9562191
source PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Acute toxicity
Cancer
Care and treatment
Chemotherapy
Clinical outcomes
Cytotoxicity
Dose-response relationship (Biochemistry)
Fever
Hyperthermia
Literature reviews
Medical prognosis
Methods
Oncology, Experimental
Patients
Quality control
Systematic Review
Temperature
Thermotherapy
Tumors
title Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T18%3A27%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Avoiding%20Pitfalls%20in%20Thermal%20Dose%20Effect%20Relationship%20Studies:%20A%20Review%20and%20Guide%20Forward&rft.jtitle=Cancers&rft.au=Carrapi%C3%A7o-Seabra,%20Carolina&rft.date=2022-09-30&rft.volume=14&rft.issue=19&rft.spage=4795&rft.pages=4795-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers14194795&rft_dat=%3Cgale_pubme%3EA745271863%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2724229506&rft_id=info:pmid/36230717&rft_galeid=A745271863&rfr_iscdi=true