Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward
The challenge to explain the diffuse and unconclusive message reported by hyperthermia studies investigating the thermal dose parameter is still to be unravelled. In the present review, we investigated a wide range of technical and clinical parameters characterising hyperthermia treatment to better...
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description | The challenge to explain the diffuse and unconclusive message reported by hyperthermia studies investigating the thermal dose parameter is still to be unravelled. In the present review, we investigated a wide range of technical and clinical parameters characterising hyperthermia treatment to better understand and improve the probability of detecting a thermal dose effect relationship in clinical studies. We performed a systematic literature review to obtain hyperthermia clinical studies investigating the associations of temperature and thermal dose parameters with treatment outcome or acute toxicity. Different hyperthermia characteristics were retrieved, and their influence on temperature and thermal dose parameters was assessed. In the literature, we found forty-eight articles investigating thermal dose effect relationships. These comprised a total of 4107 patients with different tumour pathologies. The association between thermal dose and treatment outcome was the investigated endpoint in 90% of the articles, while the correlation between thermal dose and toxicity was investigated in 50% of the articles. Significant associations between temperature-related parameters and treatment outcome were reported in 63% of the studies, while those between temperature-related parameters and toxicity were reported in 15% of the studies. One clear difficulty for advancement is that studies often omitted fundamental information regarding the clinical treatment, and among the different characteristics investigated, thermometry details were seldom and divergently reported. To overcome this, we propose a clear definition of the terms and characteristics that should be reported in clinical hyperthermia treatments. A consistent report of data will allow their use to further continue the quest for thermal dose effect relationships. |
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Van</creator><creatorcontrib>Carrapiço-Seabra, Carolina ; Curto, Sergio ; Franckena, Martine ; Rhoon, Gerard C. Van</creatorcontrib><description>The challenge to explain the diffuse and unconclusive message reported by hyperthermia studies investigating the thermal dose parameter is still to be unravelled. In the present review, we investigated a wide range of technical and clinical parameters characterising hyperthermia treatment to better understand and improve the probability of detecting a thermal dose effect relationship in clinical studies. We performed a systematic literature review to obtain hyperthermia clinical studies investigating the associations of temperature and thermal dose parameters with treatment outcome or acute toxicity. Different hyperthermia characteristics were retrieved, and their influence on temperature and thermal dose parameters was assessed. In the literature, we found forty-eight articles investigating thermal dose effect relationships. These comprised a total of 4107 patients with different tumour pathologies. The association between thermal dose and treatment outcome was the investigated endpoint in 90% of the articles, while the correlation between thermal dose and toxicity was investigated in 50% of the articles. Significant associations between temperature-related parameters and treatment outcome were reported in 63% of the studies, while those between temperature-related parameters and toxicity were reported in 15% of the studies. One clear difficulty for advancement is that studies often omitted fundamental information regarding the clinical treatment, and among the different characteristics investigated, thermometry details were seldom and divergently reported. To overcome this, we propose a clear definition of the terms and characteristics that should be reported in clinical hyperthermia treatments. A consistent report of data will allow their use to further continue the quest for thermal dose effect relationships.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers14194795</identifier><identifier>PMID: 36230717</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Acute toxicity ; Cancer ; Care and treatment ; Chemotherapy ; Clinical outcomes ; Cytotoxicity ; Dose-response relationship (Biochemistry) ; Fever ; Hyperthermia ; Literature reviews ; Medical prognosis ; Methods ; Oncology, Experimental ; Patients ; Quality control ; Systematic Review ; Temperature ; Thermotherapy ; Tumors</subject><ispartof>Cancers, 2022-09, Vol.14 (19), p.4795</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Van</creatorcontrib><title>Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward</title><title>Cancers</title><description>The challenge to explain the diffuse and unconclusive message reported by hyperthermia studies investigating the thermal dose parameter is still to be unravelled. In the present review, we investigated a wide range of technical and clinical parameters characterising hyperthermia treatment to better understand and improve the probability of detecting a thermal dose effect relationship in clinical studies. We performed a systematic literature review to obtain hyperthermia clinical studies investigating the associations of temperature and thermal dose parameters with treatment outcome or acute toxicity. Different hyperthermia characteristics were retrieved, and their influence on temperature and thermal dose parameters was assessed. In the literature, we found forty-eight articles investigating thermal dose effect relationships. These comprised a total of 4107 patients with different tumour pathologies. The association between thermal dose and treatment outcome was the investigated endpoint in 90% of the articles, while the correlation between thermal dose and toxicity was investigated in 50% of the articles. Significant associations between temperature-related parameters and treatment outcome were reported in 63% of the studies, while those between temperature-related parameters and toxicity were reported in 15% of the studies. One clear difficulty for advancement is that studies often omitted fundamental information regarding the clinical treatment, and among the different characteristics investigated, thermometry details were seldom and divergently reported. To overcome this, we propose a clear definition of the terms and characteristics that should be reported in clinical hyperthermia treatments. A consistent report of data will allow their use to further continue the quest for thermal dose effect relationships.</description><subject>Acute toxicity</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Chemotherapy</subject><subject>Clinical outcomes</subject><subject>Cytotoxicity</subject><subject>Dose-response relationship (Biochemistry)</subject><subject>Fever</subject><subject>Hyperthermia</subject><subject>Literature reviews</subject><subject>Medical prognosis</subject><subject>Methods</subject><subject>Oncology, Experimental</subject><subject>Patients</subject><subject>Quality control</subject><subject>Systematic Review</subject><subject>Temperature</subject><subject>Thermotherapy</subject><subject>Tumors</subject><issn>2072-6694</issn><issn>2072-6694</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNptkk1rHDEMhofS0oQ0514NvfSyib_GHvdQWNJ8QaAhTQ89GY8t7zrM2Ft7ZkP_fbwkpE2ofJCQH73iBTXNR4KPGFP42JpoIRfCieJStW-afYolXQih-Nt_6r3msJQ7XIMxIoV83-wxQRmWRO43v5bbFFyIK3QdJm-GoaAQ0e0a8mgG9C0VQKfeg53QDQxmCimWddigH9PsApQvaFn72wD3yESHzufgAJ2lfG-y-9C8q3oFDp_yQfPz7PT25GJx9f388mR5tbBctNOCAVHWSsd703e0syCx4Nx2UvSCdAJ3hFvgyncCqGPSctla3xLFiHeO454dNF8fdTdzP4KzEKdsBr3JYTT5j04m6Jc_Maz1Km21agUlilSBz08COf2eoUx6DMXCMJgIaS6aSrrbJ0Vb0U-v0Ls051jt7ShOqWqx-EutzAA6RJ_qXrsT1UvJWyqrL1apo_9Q9TkYg00RfKj9FwPHjwM2p1Iy-GePBOvdQehXB8EeAIM8prE</recordid><startdate>20220930</startdate><enddate>20220930</enddate><creator>Carrapiço-Seabra, Carolina</creator><creator>Curto, Sergio</creator><creator>Franckena, Martine</creator><creator>Rhoon, Gerard C. 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Van</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward</atitle><jtitle>Cancers</jtitle><date>2022-09-30</date><risdate>2022</risdate><volume>14</volume><issue>19</issue><spage>4795</spage><pages>4795-</pages><issn>2072-6694</issn><eissn>2072-6694</eissn><abstract>The challenge to explain the diffuse and unconclusive message reported by hyperthermia studies investigating the thermal dose parameter is still to be unravelled. In the present review, we investigated a wide range of technical and clinical parameters characterising hyperthermia treatment to better understand and improve the probability of detecting a thermal dose effect relationship in clinical studies. We performed a systematic literature review to obtain hyperthermia clinical studies investigating the associations of temperature and thermal dose parameters with treatment outcome or acute toxicity. 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To overcome this, we propose a clear definition of the terms and characteristics that should be reported in clinical hyperthermia treatments. A consistent report of data will allow their use to further continue the quest for thermal dose effect relationships.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>36230717</pmid><doi>10.3390/cancers14194795</doi><orcidid>https://orcid.org/0000-0002-3073-1117</orcidid><orcidid>https://orcid.org/0000-0002-7365-5783</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Acute toxicity Cancer Care and treatment Chemotherapy Clinical outcomes Cytotoxicity Dose-response relationship (Biochemistry) Fever Hyperthermia Literature reviews Medical prognosis Methods Oncology, Experimental Patients Quality control Systematic Review Temperature Thermotherapy Tumors |
title | Avoiding Pitfalls in Thermal Dose Effect Relationship Studies: A Review and Guide Forward |
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