High-throughput identification of RNA localization elements in neuronal cells

Hundreds of RNAs are enriched in the projections of neuronal cells. For the vast majority of them, though, the sequence elements that regulate their localization are unknown. To identify RNA elements capable of directing transcripts to neurites, we deployed a massively parallel reporter assay that t...

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Veröffentlicht in:	Nucleic acids research 2022-10, Vol.50 (18), p.10626-10642
Hauptverfasser:	Arora, Ankita, Castro-Gutierrez, Roberto, Moffatt, Charlie, Eletto, Davide, Becker, Raquel, Brown, Maya, Moor, Andreas E, Russ, Holger A, Taliaferro, J Matthew
Format:	Artikel
Sprache:	eng
Schlagworte:	3' Untranslated Regions - genetics Animals Humans Mice Neurons - metabolism Nucleotides - metabolism Regulatory Sequences, Ribonucleic Acid RNA and RNA-protein complexes RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Sequence Analysis, RNA
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