ABCC1 transporter exports the immunostimulatory cyclic dinucleotide cGAMP

The DNA sensor cyclic GMP-AMP synthase (cGAS) is important for antiviral and anti-tumor immunity. cGAS generates cyclic GMP-AMP (cGAMP), a diffusible cyclic dinucleotide that activates the antiviral response through the adaptor protein stimulator of interferon genes (STING). cGAMP cannot passively c...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2022-10, Vol.55 (10), p.1799-1812.e4
Hauptverfasser:	Maltbaek, Joanna H., Cambier, Stephanie, Snyder, Jessica M., Stetson, Daniel B.
Format:	Artikel
Sprache:	eng
Schlagworte:	ABCC1 Adenosine Triphosphate Aicardi-Goutières syndrome Animals cGAMP cGAS DNA - metabolism Humans interferons Interferons - metabolism Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Mice MRP1 Multidrug Resistance-Associated Proteins - genetics Multidrug Resistance-Associated Proteins - metabolism Nucleotides, Cyclic - metabolism Nucleotidyltransferases - genetics Nucleotidyltransferases - metabolism STING
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