Plasma Methylated RNF180 for Noninvasive Diagnosis of Gastric Cancer
Background. RNF180 is a tumor suppressor gene involved in cell development, proliferation, and apoptosis. Methylation of RNF180 (mRNF180) leads to low expression of RNF180, which is closely related to the occurrence and development of gastric cancer (GC). This study was designed to evaluate the pote...
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| description | Background. RNF180 is a tumor suppressor gene involved in cell development, proliferation, and apoptosis. Methylation of RNF180 (mRNF180) leads to low expression of RNF180, which is closely related to the occurrence and development of gastric cancer (GC). This study was designed to evaluate the potential performance of plasma mRNF180 as noninvasive biomarker for the diagnosis of GC. Methods. A total of 156 participants, including 60 patients with GC, 39 with chronic superficial gastritis (CSG), 27 with chronic atrophic gastritis (CAG), and 30 with gastric ulcer (GU) were recruited for this study. Plasma mRNF180 level was measured using real-time polymerase chain reaction. Results. As a diagnostic target, mRNF180 had a sensitivity of 71.67% (95% CI: 58.36%–82.18%) and specificity of 59.38% (95% CI: 48.85%–69.14%). The area under the ROC curve value of mRNF180 was 0.731 (95% CI: 0.648%–0.813%) for differentiation of GC from benign gastric diseases (BGD). The effectiveness of mRNF180 was superior to that of CEA, CA199, and CA724. mRNF180 was positively correlated with age, tumor size, T stage, N stage, M stage, and clinical stage of patients with GC. Conclusions. Plasma mRNF180 might serve as a useful and noninvasive biomarker for the diagnosis of GC and can be used to evaluate its prognosis. |
| doi_str_mv | 10.1155/2022/6548945 |
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| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9556199</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A722695786</galeid><sourcerecordid>A722695786</sourcerecordid><originalsourceid>FETCH-LOGICAL-c476t-1c53dde3af20795dad7d77a6f29ee21867cee76efd4c5fe115e2490872b4626d3</originalsourceid><addsrcrecordid>eNp9kU1rVDEUhoMottTuXMsFN4Kd9ubcfNxshDL9sFCriK5DmpzMpNxJanJnSv99M844fizM5gTy8Jy8vIS8pu0xpZyfQAtwIjjrFePPyD50lE0EZfT57t51e-SwlLu2np6KVomXZK8TwIQSYp-cfRlMWZjmE47zx8GM6JqvNxe0bxufcnOTYogrU8IKm7NgZjGVUJrkm0tTxhxsMzXRYn5FXngzFDzczgPy_eL82_Tj5Prz5dX09HpimRTjhFreOYed8dBKxZ1x0klphAeFCLQX0iJKgd4xyz3WgAhMtb2EWyZAuO6AfNh475e3C3QW45jNoO9zWJj8qJMJ-u-XGOZ6llZacS6oUlXwbivI6ccSy6gXoVgcBhMxLYsGCZwxkExW9O0_6F1a5ljj_aQodD2H39TMDKhD9KnutWupPpUAQnHZi0odbSibUykZ_e7LtNXrHvW6R73tseJv_oy5g3-1VoH3G2AeojMP4f-6J4q0oo4</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2725123852</pqid></control><display><type>article</type><title>Plasma Methylated RNF180 for Noninvasive Diagnosis of Gastric Cancer</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Zhao, Luyao ; Liu, Yandi ; Zhang, Shiwu ; Li, Muran</creator><contributor>Aziz, Aziz ur Rehman ; Aziz ur Rehman Aziz</contributor><creatorcontrib>Zhao, Luyao ; Liu, Yandi ; Zhang, Shiwu ; Li, Muran ; Aziz, Aziz ur Rehman ; Aziz ur Rehman Aziz</creatorcontrib><description>Background. RNF180 is a tumor suppressor gene involved in cell development, proliferation, and apoptosis. Methylation of RNF180 (mRNF180) leads to low expression of RNF180, which is closely related to the occurrence and development of gastric cancer (GC). This study was designed to evaluate the potential performance of plasma mRNF180 as noninvasive biomarker for the diagnosis of GC. Methods. A total of 156 participants, including 60 patients with GC, 39 with chronic superficial gastritis (CSG), 27 with chronic atrophic gastritis (CAG), and 30 with gastric ulcer (GU) were recruited for this study. Plasma mRNF180 level was measured using real-time polymerase chain reaction. Results. As a diagnostic target, mRNF180 had a sensitivity of 71.67% (95% CI: 58.36%–82.18%) and specificity of 59.38% (95% CI: 48.85%–69.14%). The area under the ROC curve value of mRNF180 was 0.731 (95% CI: 0.648%–0.813%) for differentiation of GC from benign gastric diseases (BGD). The effectiveness of mRNF180 was superior to that of CEA, CA199, and CA724. mRNF180 was positively correlated with age, tumor size, T stage, N stage, M stage, and clinical stage of patients with GC. Conclusions. Plasma mRNF180 might serve as a useful and noninvasive biomarker for the diagnosis of GC and can be used to evaluate its prognosis.</description><identifier>ISSN: 2314-6133</identifier><identifier>ISSN: 2314-6141</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2022/6548945</identifier><identifier>PMID: 36246966</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Antigens ; Apoptosis ; Biological markers ; Biomarkers ; Biomarkers, Tumor - genetics ; Biopsy ; Cancer ; Cancer therapies ; Carcinoembryonic Antigen ; Diagnosis ; Diagnosis, Noninvasive ; DNA methylation ; Epigenetics ; Gastric cancer ; Gastritis ; Gastritis, Atrophic - genetics ; Gene expression ; Genetic aspects ; Genomes ; Humans ; Identification and classification ; Medical prognosis ; Methods ; Mortality ; Mutation ; Patients ; Performance evaluation ; Plasma ; Polymerase chain reaction ; Precancerous Conditions - genetics ; Prognosis ; Proteins ; Signal transduction ; Software ; Stomach cancer ; Stomach Neoplasms - diagnosis ; Stomach Neoplasms - genetics ; Stomach Neoplasms - pathology ; Surgery ; Trinucleotide repeats ; Tumor suppressor genes ; Tumors ; Ubiquitin-Protein Ligases - genetics</subject><ispartof>BioMed research international, 2022, Vol.2022 (1), p.6548945</ispartof><rights>Copyright © 2022 Luyao Zhao et al.</rights><rights>COPYRIGHT 2022 John Wiley & Sons, Inc.</rights><rights>Copyright © 2022 Luyao Zhao et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2022 Luyao Zhao et al. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c476t-1c53dde3af20795dad7d77a6f29ee21867cee76efd4c5fe115e2490872b4626d3</citedby><cites>FETCH-LOGICAL-c476t-1c53dde3af20795dad7d77a6f29ee21867cee76efd4c5fe115e2490872b4626d3</cites><orcidid>0000-0002-5052-2283 ; 0000-0003-1225-2304 ; 0000-0001-9160-2450 ; 0000-0002-5960-9254</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556199/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9556199/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,882,4010,27904,27905,27906,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36246966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Aziz, Aziz ur Rehman</contributor><contributor>Aziz ur Rehman Aziz</contributor><creatorcontrib>Zhao, Luyao</creatorcontrib><creatorcontrib>Liu, Yandi</creatorcontrib><creatorcontrib>Zhang, Shiwu</creatorcontrib><creatorcontrib>Li, Muran</creatorcontrib><title>Plasma Methylated RNF180 for Noninvasive Diagnosis of Gastric Cancer</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. RNF180 is a tumor suppressor gene involved in cell development, proliferation, and apoptosis. Methylation of RNF180 (mRNF180) leads to low expression of RNF180, which is closely related to the occurrence and development of gastric cancer (GC). This study was designed to evaluate the potential performance of plasma mRNF180 as noninvasive biomarker for the diagnosis of GC. Methods. A total of 156 participants, including 60 patients with GC, 39 with chronic superficial gastritis (CSG), 27 with chronic atrophic gastritis (CAG), and 30 with gastric ulcer (GU) were recruited for this study. Plasma mRNF180 level was measured using real-time polymerase chain reaction. Results. As a diagnostic target, mRNF180 had a sensitivity of 71.67% (95% CI: 58.36%–82.18%) and specificity of 59.38% (95% CI: 48.85%–69.14%). The area under the ROC curve value of mRNF180 was 0.731 (95% CI: 0.648%–0.813%) for differentiation of GC from benign gastric diseases (BGD). The effectiveness of mRNF180 was superior to that of CEA, CA199, and CA724. mRNF180 was positively correlated with age, tumor size, T stage, N stage, M stage, and clinical stage of patients with GC. Conclusions. Plasma mRNF180 might serve as a useful and noninvasive biomarker for the diagnosis of GC and can be used to evaluate its prognosis.</description><subject>Antigens</subject><subject>Apoptosis</subject><subject>Biological markers</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor - genetics</subject><subject>Biopsy</subject><subject>Cancer</subject><subject>Cancer therapies</subject><subject>Carcinoembryonic Antigen</subject><subject>Diagnosis</subject><subject>Diagnosis, Noninvasive</subject><subject>DNA methylation</subject><subject>Epigenetics</subject><subject>Gastric cancer</subject><subject>Gastritis</subject><subject>Gastritis, Atrophic - genetics</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Humans</subject><subject>Identification and classification</subject><subject>Medical prognosis</subject><subject>Methods</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Patients</subject><subject>Performance evaluation</subject><subject>Plasma</subject><subject>Polymerase chain reaction</subject><subject>Precancerous Conditions - genetics</subject><subject>Prognosis</subject><subject>Proteins</subject><subject>Signal transduction</subject><subject>Software</subject><subject>Stomach cancer</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - pathology</subject><subject>Surgery</subject><subject>Trinucleotide repeats</subject><subject>Tumor suppressor genes</subject><subject>Tumors</subject><subject>Ubiquitin-Protein Ligases - genetics</subject><issn>2314-6133</issn><issn>2314-6141</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp9kU1rVDEUhoMottTuXMsFN4Kd9ubcfNxshDL9sFCriK5DmpzMpNxJanJnSv99M844fizM5gTy8Jy8vIS8pu0xpZyfQAtwIjjrFePPyD50lE0EZfT57t51e-SwlLu2np6KVomXZK8TwIQSYp-cfRlMWZjmE47zx8GM6JqvNxe0bxufcnOTYogrU8IKm7NgZjGVUJrkm0tTxhxsMzXRYn5FXngzFDzczgPy_eL82_Tj5Prz5dX09HpimRTjhFreOYed8dBKxZ1x0klphAeFCLQX0iJKgd4xyz3WgAhMtb2EWyZAuO6AfNh475e3C3QW45jNoO9zWJj8qJMJ-u-XGOZ6llZacS6oUlXwbivI6ccSy6gXoVgcBhMxLYsGCZwxkExW9O0_6F1a5ljj_aQodD2H39TMDKhD9KnutWupPpUAQnHZi0odbSibUykZ_e7LtNXrHvW6R73tseJv_oy5g3-1VoH3G2AeojMP4f-6J4q0oo4</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Zhao, Luyao</creator><creator>Liu, Yandi</creator><creator>Zhang, Shiwu</creator><creator>Li, Muran</creator><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-5052-2283</orcidid><orcidid>https://orcid.org/0000-0003-1225-2304</orcidid><orcidid>https://orcid.org/0000-0001-9160-2450</orcidid><orcidid>https://orcid.org/0000-0002-5960-9254</orcidid></search><sort><creationdate>2022</creationdate><title>Plasma Methylated RNF180 for Noninvasive Diagnosis of Gastric Cancer</title><author>Zhao, Luyao ; Liu, Yandi ; Zhang, Shiwu ; Li, Muran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c476t-1c53dde3af20795dad7d77a6f29ee21867cee76efd4c5fe115e2490872b4626d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antigens</topic><topic>Apoptosis</topic><topic>Biological markers</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor - genetics</topic><topic>Biopsy</topic><topic>Cancer</topic><topic>Cancer therapies</topic><topic>Carcinoembryonic Antigen</topic><topic>Diagnosis</topic><topic>Diagnosis, Noninvasive</topic><topic>DNA methylation</topic><topic>Epigenetics</topic><topic>Gastric cancer</topic><topic>Gastritis</topic><topic>Gastritis, Atrophic - genetics</topic><topic>Gene expression</topic><topic>Genetic aspects</topic><topic>Genomes</topic><topic>Humans</topic><topic>Identification and classification</topic><topic>Medical prognosis</topic><topic>Methods</topic><topic>Mortality</topic><topic>Mutation</topic><topic>Patients</topic><topic>Performance evaluation</topic><topic>Plasma</topic><topic>Polymerase chain reaction</topic><topic>Precancerous Conditions - genetics</topic><topic>Prognosis</topic><topic>Proteins</topic><topic>Signal transduction</topic><topic>Software</topic><topic>Stomach cancer</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - pathology</topic><topic>Surgery</topic><topic>Trinucleotide repeats</topic><topic>Tumor suppressor genes</topic><topic>Tumors</topic><topic>Ubiquitin-Protein Ligases - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Luyao</creatorcontrib><creatorcontrib>Liu, Yandi</creatorcontrib><creatorcontrib>Zhang, Shiwu</creatorcontrib><creatorcontrib>Li, Muran</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Luyao</au><au>Liu, Yandi</au><au>Zhang, Shiwu</au><au>Li, Muran</au><au>Aziz, Aziz ur Rehman</au><au>Aziz ur Rehman Aziz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Methylated RNF180 for Noninvasive Diagnosis of Gastric Cancer</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2022</date><risdate>2022</risdate><volume>2022</volume><issue>1</issue><spage>6548945</spage><pages>6548945-</pages><issn>2314-6133</issn><issn>2314-6141</issn><eissn>2314-6141</eissn><abstract>Background. RNF180 is a tumor suppressor gene involved in cell development, proliferation, and apoptosis. Methylation of RNF180 (mRNF180) leads to low expression of RNF180, which is closely related to the occurrence and development of gastric cancer (GC). This study was designed to evaluate the potential performance of plasma mRNF180 as noninvasive biomarker for the diagnosis of GC. Methods. A total of 156 participants, including 60 patients with GC, 39 with chronic superficial gastritis (CSG), 27 with chronic atrophic gastritis (CAG), and 30 with gastric ulcer (GU) were recruited for this study. Plasma mRNF180 level was measured using real-time polymerase chain reaction. Results. As a diagnostic target, mRNF180 had a sensitivity of 71.67% (95% CI: 58.36%–82.18%) and specificity of 59.38% (95% CI: 48.85%–69.14%). The area under the ROC curve value of mRNF180 was 0.731 (95% CI: 0.648%–0.813%) for differentiation of GC from benign gastric diseases (BGD). The effectiveness of mRNF180 was superior to that of CEA, CA199, and CA724. mRNF180 was positively correlated with age, tumor size, T stage, N stage, M stage, and clinical stage of patients with GC. Conclusions. Plasma mRNF180 might serve as a useful and noninvasive biomarker for the diagnosis of GC and can be used to evaluate its prognosis.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>36246966</pmid><doi>10.1155/2022/6548945</doi><orcidid>https://orcid.org/0000-0002-5052-2283</orcidid><orcidid>https://orcid.org/0000-0003-1225-2304</orcidid><orcidid>https://orcid.org/0000-0001-9160-2450</orcidid><orcidid>https://orcid.org/0000-0002-5960-9254</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Antigens Apoptosis Biological markers Biomarkers Biomarkers, Tumor - genetics Biopsy Cancer Cancer therapies Carcinoembryonic Antigen Diagnosis Diagnosis, Noninvasive DNA methylation Epigenetics Gastric cancer Gastritis Gastritis, Atrophic - genetics Gene expression Genetic aspects Genomes Humans Identification and classification Medical prognosis Methods Mortality Mutation Patients Performance evaluation Plasma Polymerase chain reaction Precancerous Conditions - genetics Prognosis Proteins Signal transduction Software Stomach cancer Stomach Neoplasms - diagnosis Stomach Neoplasms - genetics Stomach Neoplasms - pathology Surgery Trinucleotide repeats Tumor suppressor genes Tumors Ubiquitin-Protein Ligases - genetics |
| title | Plasma Methylated RNF180 for Noninvasive Diagnosis of Gastric Cancer |
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