Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis

ObjectiveAberrant lipid metabolism is a hallmark of colorectal cancer (CRC). Squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol biosynthesis, is upregulated in CRC. Here, we aim to determine oncogenic function of SQLE and its interplay with gut microbiota in promoting colorectal tumour...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Gut 2022-11, Vol.71 (11), p.2253-2265
Hauptverfasser:	Li, Chuangen, Wang, Yong, Liu, Dabin, Wong, Chi Chun, Coker, Olabisi Oluwabukola, Zhang, Xiang, Liu, Changan, Zhou, Yunfei, Liu, Yali, Kang, Wei, To, Ka Fai, Sung, Joseph JY, Yu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Fluorouracil Animal models Apoptosis Azoxymethane Bacteria Bile acids Cancer therapies Carcinogenesis CDX2 protein Cell cycle Cell growth Cell proliferation Chemotherapy Cholesterol Colon colonic microflora Colorectal cancer Colorectal carcinoma colorectal neoplasm Drug resistance Dysbacteriosis Gene expression Genomes Germfree Intestinal microflora Lipid metabolism Lipids Low income groups Medical prognosis Metabolism Metabolomics Metastasis Microbiota Mortality Oxaliplatin Pathogenesis Patients Permeability Rodents Squalene Squalene epoxidase Surgery Terbinafine Transgenic animals Transgenic mice Transplantation Tumorigenesis Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!