Activation of GPR183 by 7 α,25-Dihydroxycholesterol Induces Behavioral Hypersensitivity through Mitogen-Activated Protein Kinase and Nuclear Factor-κ B

Emerging evidence implicates the G-protein coupled receptor (GPCR) GPR183 in the development of neuropathic pain. Further investigation of the signaling pathways downstream of GPR183 is needed to support the development of GPR183 antagonists as analgesics. In rodents, intrathecal injection of its li...

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Veröffentlicht in:	The Journal of pharmacology and experimental therapeutics 2022-11, Vol.383 (2), p.172-181
Hauptverfasser:	Braden, Kathryn, Campolo, Michela, Li, Ying, Chen, Zhoumou, Doyle, Timothy M., Giancotti, Luigino Antonio, Esposito, Emanuela, Zhang, Jinsong, Cuzzocrea, Salvatore, Arnatt, Christopher Kent, Salvemini, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals beta-Arrestin 1 - metabolism Cytokines - metabolism Extracellular Signal-Regulated MAP Kinases - metabolism Hyperalgesia - chemically induced Ligands Mice Neuropharmacology NF-kappa B - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Receptors, G-Protein-Coupled - metabolism
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