BAP1 maintains HIF-dependent interferon beta induction to suppress tumor growth in clear cell renal cell carcinoma

BRCA1-associated protein 1 (BAP1) is a deubiquitinase that is mutated in 10–15% of clear cell renal cell carcinomas (ccRCC). Despite the association between BAP1 loss and poor clinical outcome, the critical tumor suppressor function(s) of BAP1 in ccRCC remains unclear. Previously, we found that hypo...

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Veröffentlicht in:	Cancer letters 2022-10, Vol.547, p.215885-215885, Article 215885
Hauptverfasser:	Langbein, Lauren E., El Hajjar, Rayan, He, Shen, Sementino, Eleonora, Zhong, Zhijiu, Jiang, Wei, Leiby, Benjamin E., Li, Li, Uzzo, Robert G., Testa, Joseph R., Yang, Haifeng
Format:	Artikel
Sprache:	eng
Schlagworte:	BAP1 Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - metabolism BRCA1 protein Cancer Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - genetics Carcinoma, Renal Cell - pathology ccRCC Cell growth Cell Line, Tumor Clear cell-type renal cell carcinoma Gene Expression Regulation, Neoplastic HIF Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism Hypoxia-inducible factors Interferon Interferon-beta - genetics Kidney cancer Kidney Neoplasms - drug therapy Kidney Neoplasms - genetics Kidney Neoplasms - metabolism Kinases Mutation Plasmids STING Tumor suppressor genes Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism Tumors Ubiquitin Thiolesterase - genetics Ubiquitin Thiolesterase - metabolism VHL protein Von Hippel-Lindau Tumor Suppressor Protein - genetics Von Hippel-Lindau Tumor Suppressor Protein - metabolism Xenografts β-Interferon
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