Population-level variation in enhancer expression identifies disease mechanisms in the human brain

Identification of risk variants for neuropsychiatric diseases within enhancers underscores the importance of understanding population-level variation in enhancer function in the human brain. Besides regulating tissue-specific and cell-type-specific transcription of target genes, enhancers themselves...

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Veröffentlicht in:	Nature genetics 2022-10, Vol.54 (10), p.1493-1503
Hauptverfasser:	Dong, Pengfei, Hoffman, Gabriel E., Apontes, Pasha, Bendl, Jaroslav, Rahman, Samir, Fernando, Michael B., Zeng, Biao, Vicari, James M., Zhang, Wen, Girdhar, Kiran, Townsley, Kayla G., Misir, Ruth, Brennand, Kristen J., Haroutunian, Vahram, Voloudakis, Georgios, Fullard, John F., Roussos, Panos
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/200 631/378 Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Brain Cancer Research Disease Enhancer Elements, Genetic - genetics Enhancers Gene expression Gene Function Gene mapping Genes Genome-Wide Association Study Heritability Human Genetics Humans Machine learning Mental disorders Neurons Population Quantitative trait loci Quantitative Trait Loci - genetics Regulatory Sequences, Nucleic Acid Transcriptome - genetics Transcriptomes
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