Alterations in a cross-hemispheric circuit associates with novelty discrimination deficits in mouse models of neurodegeneration

A major pathological hallmark of neurodegenerative diseases, including Alzheimer’s, is a significant reduction in the white matter connecting the two cerebral hemispheres, as well as in the correlated activity between anatomically corresponding bilateral brain areas. However, the underlying circuit...

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Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2022-10, Vol.110 (19), p.3091-3105.e9
Hauptverfasser:	Adaikkan, Chinnakkaruppan, Wang, Jun, Abdelaal, Karim, Middleton, Steven J., Bozzelli, P. Lorenzo, Wickersham, Ian R., McHugh, Thomas J., Tsai, Li-Huei
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer’s disease CH neurons cross-hemispheric circuit gamma oscillations interhemispheric circuit novelty discrimination PV interneurons theta oscillations
Online-Zugang:	Volltext
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