Low NUDT15 expression levels due to bi-allelic NUDT15 variants and 6-mercaptopurine intolerance

6-Mercaptopurine (6-MP) is widely used for the treatment of pediatric leukemia and lymphoma. Recently, germline variants in the NUDT15 gene have been identified as one of the major genetic causes for 6-MP–associated adverse effects such as myelosuppression. Patients with hypomorphic NUDT15 variants...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	British journal of haematology 2022-07, Vol.199 (2), p.270-276
Hauptverfasser:	Yoshida, Masanori, Brown, Scott A, Moriyama, Takaya, Nishii, Rina, Tsujimoto, Shin-ichi, Yamada, Yuji, Yoshida, Kaoru, Shirai, Ryota, Osumi, Tomoo, Utano, Tomoyuki, Fukano, Reiji, Kudo, Ko, Sakaguchi, Kimiyoshi, Arakawa, Yuki, Koh, Katsuyoshi, Sekiguchi, Masahiro, Sekimizu, Masahiro, Miyamura, Takako, Ishida, Hisashi, Inukai, Takeshi, Tomizawa, Daisuke, Kiyokawa, Nobutaka, Kato, Motohiro, Yang, Jun J
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!