TFG regulates secretory and endosomal sorting pathways in neurons to promote their activity and maintenance

Molecular pathways that intrinsically regulate neuronal maintenance are poorly understood, but rare pathogenic mutations that underlie neurodegenerative disease can offer important insights into the mechanisms that facilitate lifelong neuronal function. Here, we leverage a rat model to demonstrate d...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2022-10, Vol.119 (40), p.1-12
Hauptverfasser: Peotter, Jennifer L., Pustova, Iryna, Lettman, Molly M., Shatadal, Shalini, Bradberry, Mazdak M., Winter-Reed, Allison D., Charan, Maya, Sharkey, Erin E., Alvin, James R., Bren, Alyssa M., Oie, Annika K., Chapman, Edwin R., Salamat, M. Shahriar, Audhyaa, Anjon
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Sprache:eng
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