FGFR4-targeted chimeric antigen receptors (CARs) combined with anti-myeloid polypharmacy effectively treats orthotopic rhabdomyosarcoma

Rhabdomyosarcoma (RMS) is the most common soft tissue cancer in children. Treatment outcomes, particularly for relapsed/refractory or metastatic disease, have not improved in decades. The current lack of novel therapies and low tumor mutational burden suggest that CAR T therapy could be a promising...

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Veröffentlicht in:	Molecular cancer therapeutics 2022-10, Vol.21 (10), p.1608-1621
Hauptverfasser:	Sullivan, Peter M., Kumar, Rajesh, Li, Wei, Hoglund, Virginia, Wang, Lingyang, Zhang, Yue, Shi, Megan, Beak, Dusan, Cheuk, Adam, Jensen, Michael C., Khan, Javed, Dimitrov, Dimiter S., Orentas, Rimas J.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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