Assessing Reactive Astrogliosis with 18F-SMBT-1 Across the Alzheimer Disease Spectrum

A neuroinflammatory reaction in Alzheimer disease (AD) brains involves reactive astrocytes that overexpress monoamine oxidase-B (MAO-B). 18F-(S)-(2-methylpyrid-5-yl)-6-[(3-fluoro-2-hydroxy)propoxy]quinoline (18F-SMBT-1) is a novel 18F PET tracer highly selective for MAO-B. We characterized the clini...

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Veröffentlicht in:	The Journal of nuclear medicine (1978) 2022-10, Vol.63 (10), p.1560-1569
Hauptverfasser:	Villemagne, Victor L, Harada, Ryuichi, Doré, Vincent, Furumoto, Shozo, Mulligan, Rachel, Kudo, Yukitsuka, Burnham, Samantha, Krishnadas, Natasha, Bourgeat, Pierrick, Xia, Ying, Laws, Simon, Bozinovski, Svetlana, Huang, Kun, Ikonomovic, Milos D, Fripp, Jürgen, Yanai, Kazuhiko, Okamura, Nobuyuki, Rowe, Christopher C
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amine oxidase (flavin-containing) Astrocytes Basal ganglia Binding Biomarkers Brain Cerebellum Clinical Investigation Cognitive ability Correlation Cortex (frontal) Dementia disorders Fluorine isotopes Ganglia Gliosis Hippocampus Image contrast Impairment Inflammation Medical imaging Neurodegenerative diseases Neuroimaging Occipital lobe Positron emission Positron emission tomography Quinoline Regions Substantia alba Substantia grisea Tau protein Temporal cortex Temporal lobe Tomography β-Amyloid
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