T Lymphocyte-Derived Exosomes Transport MEK1/2 and ERK1/2 and Induce NOX4-Dependent Oxidative Stress in Cardiac Microvascular Endothelial Cells

Background. Activation of endothelial cells by inflammatory mediators secreted by CD4+ T lymphocytes plays a key role in the inflammatory response. Exosomes represent a specific class of signaling cues transporting a mixture of proteins, nucleic acids, and other biomolecules. So far, the impact of e...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Oxidative medicine and cellular longevity 2022-09, Vol.2022, p.1-17
Hauptverfasser:	Rolski, Filip, Czepiel, Marcin, Tkacz, Karolina, Fryt, Katarzyna, Siedlar, Maciej, Kania, Gabriela, Błyszczuk, Przemysław
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens Atherosclerosis Cardiovascular disease Experiments Growth factors Heart Inflammation Lymphocytes Nitric oxide Oxidative stress Proteins Reactive oxygen species T cell receptors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!