Building synapses: Using a synthetic approach to bridge synaptic membranes
Synapses are specialized cellular junctions essential for communication between neurons. Synapse loss occurs in many neurodegenerative diseases. Harnessing our molecular knowledge of the development and maintenance of synapses, Suzuki . present the first comprehensive attempt to use a synthetic prot...
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| Veröffentlicht in: | Faculty reviews 2022, Vol.11, p.25-25 |
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| container_title | Faculty reviews |
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| creator | Kim, Christina K Kolodkin, Alex L Shen, Kang Stuber, Garret D |
| description | Synapses are specialized cellular junctions essential for communication between neurons. Synapse loss occurs in many neurodegenerative diseases. Harnessing our molecular knowledge of the development and maintenance of synapses, Suzuki
. present the first comprehensive attempt to use a synthetic protein to bridge the pre- and postsynaptic membranes
. They show that this powerful approach can stimulate the formation of pre- and postsynaptic specializations
, rescue synaptic deficits of mutant mice
, and ameliorate synapse loss and behavioral abnormalities in both Alzheimer's disease and spinal cord injury mouse models. |
| doi_str_mv | 10.12703/r-01-0000017 |
| format | Article |
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. present the first comprehensive attempt to use a synthetic protein to bridge the pre- and postsynaptic membranes
. They show that this powerful approach can stimulate the formation of pre- and postsynaptic specializations
, rescue synaptic deficits of mutant mice
, and ameliorate synapse loss and behavioral abnormalities in both Alzheimer's disease and spinal cord injury mouse models.</description><identifier>ISSN: 2732-432X</identifier><identifier>EISSN: 2732-432X</identifier><identifier>DOI: 10.12703/r-01-0000017</identifier><identifier>PMID: 36262561</identifier><language>eng</language><publisher>England: Faculty Opinions Ltd</publisher><subject>Review</subject><ispartof>Faculty reviews, 2022, Vol.11, p.25-25</ispartof><rights>Copyright: © 2022 Faculty Opinions Ltd.</rights><rights>Copyright: © 2022 Faculty Opinions Ltd. 2022</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-7562-5513 ; 0000-0003-1730-4855 ; 0000-0002-1466-7098 ; 0000-0003-4059-8249</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533766/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9533766/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36262561$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Christina K</creatorcontrib><creatorcontrib>Kolodkin, Alex L</creatorcontrib><creatorcontrib>Shen, Kang</creatorcontrib><creatorcontrib>Stuber, Garret D</creatorcontrib><title>Building synapses: Using a synthetic approach to bridge synaptic membranes</title><title>Faculty reviews</title><addtitle>Fac Rev</addtitle><description>Synapses are specialized cellular junctions essential for communication between neurons. Synapse loss occurs in many neurodegenerative diseases. Harnessing our molecular knowledge of the development and maintenance of synapses, Suzuki
. present the first comprehensive attempt to use a synthetic protein to bridge the pre- and postsynaptic membranes
. They show that this powerful approach can stimulate the formation of pre- and postsynaptic specializations
, rescue synaptic deficits of mutant mice
, and ameliorate synapse loss and behavioral abnormalities in both Alzheimer's disease and spinal cord injury mouse models.</description><subject>Review</subject><issn>2732-432X</issn><issn>2732-432X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><recordid>eNpVkUtPwzAMxyMEYtPYkSvqkUshzyblgAQTT03iwiRuUZqkW1BfJC3Svj0tHdPwxXb809-ODcA5glcIc0iufQxRDAdD_AhMMSc4pgR_HB_EEzAP4bNHcIoxFvwUTEiCE8wSNAWv950rjKvWUdhWqgk23ESrMORqeGk3tnU6Uk3ja6U3UVtHmXdmbUd8qJW2zLyqbDgDJ7kqgp3v_AysHh_eF8_x8u3pZXG3jDUSgsfYaKMIR1oISLmmmjBISU65yTUjSEGW09RkOhU6g5jBVCU5s1bkzFBIrCYzcDvqNl1WWqNt1XpVyMa7UvmtrJWT_yuV28h1_S1TRghPkl7gcifg66_OhlaWLmhbFP0v6i5IzHGSYsqJ6NF4RLWvQ_A237dBUP6eQHoJkdydoOcvDmfb038LJz-mgIKg</recordid><startdate>2022</startdate><enddate>2022</enddate><creator>Kim, Christina K</creator><creator>Kolodkin, Alex L</creator><creator>Shen, Kang</creator><creator>Stuber, Garret D</creator><general>Faculty Opinions Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7562-5513</orcidid><orcidid>https://orcid.org/0000-0003-1730-4855</orcidid><orcidid>https://orcid.org/0000-0002-1466-7098</orcidid><orcidid>https://orcid.org/0000-0003-4059-8249</orcidid></search><sort><creationdate>2022</creationdate><title>Building synapses: Using a synthetic approach to bridge synaptic membranes</title><author>Kim, Christina K ; Kolodkin, Alex L ; Shen, Kang ; Stuber, Garret D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1887-2dcda371c88047c4c35043f47dfc531a05f49dbc98cb02509a6f5ee8f5d403ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Review</topic><toplevel>online_resources</toplevel><creatorcontrib>Kim, Christina K</creatorcontrib><creatorcontrib>Kolodkin, Alex L</creatorcontrib><creatorcontrib>Shen, Kang</creatorcontrib><creatorcontrib>Stuber, Garret D</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Faculty reviews</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Christina K</au><au>Kolodkin, Alex L</au><au>Shen, Kang</au><au>Stuber, Garret D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Building synapses: Using a synthetic approach to bridge synaptic membranes</atitle><jtitle>Faculty reviews</jtitle><addtitle>Fac Rev</addtitle><date>2022</date><risdate>2022</risdate><volume>11</volume><spage>25</spage><epage>25</epage><pages>25-25</pages><issn>2732-432X</issn><eissn>2732-432X</eissn><abstract>Synapses are specialized cellular junctions essential for communication between neurons. Synapse loss occurs in many neurodegenerative diseases. Harnessing our molecular knowledge of the development and maintenance of synapses, Suzuki
. present the first comprehensive attempt to use a synthetic protein to bridge the pre- and postsynaptic membranes
. They show that this powerful approach can stimulate the formation of pre- and postsynaptic specializations
, rescue synaptic deficits of mutant mice
, and ameliorate synapse loss and behavioral abnormalities in both Alzheimer's disease and spinal cord injury mouse models.</abstract><cop>England</cop><pub>Faculty Opinions Ltd</pub><pmid>36262561</pmid><doi>10.12703/r-01-0000017</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-7562-5513</orcidid><orcidid>https://orcid.org/0000-0003-1730-4855</orcidid><orcidid>https://orcid.org/0000-0002-1466-7098</orcidid><orcidid>https://orcid.org/0000-0003-4059-8249</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Faculty reviews, 2022, Vol.11, p.25-25 |
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| source | PubMed Central; Alma/SFX Local Collection |
| subjects | Review |
| title | Building synapses: Using a synthetic approach to bridge synaptic membranes |
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