Novel VHH-Based Tracers with Variable Plasma Half-Lives for Imaging of CAIX-Expressing Hypoxic Tumor Cells

Hypoxic areas are present in the majority of solid tumors, and hypoxia is associated with resistance to therapies and poor outcomes. A transmembrane protein that is upregulated by tumor cells that have adapted to hypoxic conditions is carbonic anhydrase IX (CAIX). Therefore, noninvasive imaging of C...

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Veröffentlicht in:	Molecular pharmaceutics 2022-10, Vol.19 (10), p.3511-3520
Hauptverfasser:	van Lith, Sanne A.M., Huizing, Fokko J., Franssen, Gerben M., Hoeben, Bianca A.W., Lok, Jasper, Doulkeridou, Sofia, Boerman, Otto C., Gotthardt, Martin, van Bergen en Henegouwen, Paul M.P., Bussink, Johan, Heskamp, Sandra
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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