Inhalation of Silver Silicate Nanoparticles Leads to Transient and Differential Microglial Activation in the Rodent Olfactory Bulb

Engineered silver nanoparticles (AgNPs), including silver silicate nanoparticles (Ag-SiO2 NPs), are used in a wide variety of medical and consumer applications. Inhaled AgNPs have been found to translocate to the olfactory bulb (OB) after inhalation and intranasal instillation. However, the biologic...

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Veröffentlicht in:	Toxicologic pathology 2022-08, Vol.50 (6), p.763-775
Hauptverfasser:	Huynh, Huong, Upadhyay, Priya, Lopez, Cora H., Miyashiro, Malia K., Van Winkle, Laura S., Thomasy, Sara M., Pinkerton, Kent E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aerosols - analysis Aerosols - metabolism Aerosols - pharmacology Animals Calcium Heme Oxygenase-1 - analysis Heme Oxygenase-1 - metabolism Heme Oxygenase-1 - pharmacology Metal Nanoparticles - toxicity Microglia - metabolism Olfactory Bulb Rats Rats, Sprague-Dawley Rodentia - metabolism Silicates - analysis Silicates - metabolism Silicates - toxicity Silicon Dioxide - toxicity Silver - toxicity
Online-Zugang:	Volltext
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