Arachidonate 5-lipoxygenase is essential for biosynthesis of specialized pro-resolving mediators and cardiac repair in heart failure

Arachidonate 5-lipoxygenase (ALOX5)-derived leukotrienes are primary signals of leukocyte activation and inflammation in response to ischemic cardiac injury (MI; myocardial infarction). Using risk-free male C57BL/6J and ALOX5-null mice (8-12 wk), we quantitated leukocytes and ALOX5-derived bioactive...

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Veröffentlicht in:	American journal of physiology. Heart and circulatory physiology 2022-10, Vol.323 (4), p.H721-H737
Hauptverfasser:	Halade, Ganesh V, Kain, Vasundhara, Hossain, Shahriare, Parcha, Vibhu, Limdi, Nita A, Arora, Pankaj
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arachidonate 5-Lipoxygenase - genetics Arachidonate 5-Lipoxygenase - metabolism Heart Failure Inflammation - metabolism Inflammation Mediators - metabolism Leukotrienes Male Mice Mice, Inbred C57BL Mice, Knockout Myocardial Infarction Prostaglandin-Endoperoxide Synthases
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