WRN rescues replication forks compromised by a BRCA2 deficiency: Predictions for how inhibition of a helicase that suppresses premature aging tilts the balance to fork demise and chromosomal instability in cancer

Hereditary breast and ovarian cancers are frequently attributed to germline mutations in the tumor suppressor genes BRCA1 and BRCA2. BRCA1/2 act to repair double‐strand breaks (DSBs) and suppress the demise of unstable replication forks. Our work elucidated a dynamic interplay between BRCA2 and the...

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Veröffentlicht in:	BioEssays 2022-08, Vol.44 (8), p.e2200057-n/a
Hauptverfasser:	Datta, Arindam, Brosh, Robert M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Aging, Premature BRCA1 protein BRCA2 BRCA2 protein BRCA2 Protein - genetics BRCA2 Protein - metabolism Breast cancer Cancer Chromosomal Instability Deoxyribonucleic acid DNA DNA helicase DNA Helicases - chemistry DNA repair DNA Replication Exodeoxyribonucleases - genetics Exodeoxyribonucleases - metabolism Exonuclease genetic disease Genomic instability Humans Metabolism Mutation Neoplasms - drug therapy Neoplasms - genetics Ovarian cancer Poly(ADP-ribose) polymerase Replication Replication forks replication stress synthetic lethality Telomeres Tumor suppressor genes Tumors Werner Syndrome - genetics Werner Syndrome - metabolism Werner Syndrome Helicase - genetics Werner Syndrome Helicase - metabolism Werner's syndrome WRN
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