Rational Design of Silicon‐Based Zinc Ionophores

Ionophores transport ions across biological membranes and have wide‐ranging applications, but a platform for their rapid development does not exist. We report a platform for developing ionophores from metal‐ion chelators, which are readily available with wide‐ranging affinities and specificities, an...

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Veröffentlicht in:	Angewandte Chemie International Edition 2022-06, Vol.61 (23), p.e202201698-n/a
Hauptverfasser:	Yamada, Kei, Deb, Arghya, Shoba, Veronika M., Lim, Donghyun, Maji, Basudeb, Modell, Ashley E., Choudhary, Amit
Format:	Artikel
Sprache:	eng
Schlagworte:	Affinity Animals Antibacterial Activity Antibacterial agents Binding Biological membranes Chelating agents Chelating Agents - pharmacology Chelation Design Heavy metals Ionophores Ionophores - chemistry Ions Mammalian cells Mammals - metabolism Metals Pyrithione Silicon Silyl Groups Toxicity Zinc - metabolism Zinc Ions
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