The phosphorylation and dephosphorylation switch of VCP/p97 regulates the architecture of centrosome and spindle

The proper orientation of centrosome and spindle is essential for genome stability; however, the mechanism that governs these processes remains elusive. Here, we demonstrated that polo-like kinase 1 (Plk1), a key mitotic kinase, phosphorylates residue Thr76 in VCP/p97 (an AAA-ATPase), at the centros...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cell death and differentiation 2022-10, Vol.29 (10), p.2070-2088
Hauptverfasser:	Zhu, Kaiyuan, Cai, Yang, Si, Xiaotong, Ye, Zuodong, Gao, Yuanzhu, Liu, Chuang, Wang, Rui, Ma, Zhibin, Zhu, Huazhang, Zhang, Liang, Li, Shengjin, Zhang, Hongmin, Yue, Jianbo
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 101/58 13/31 13/89 13/95 14 14/19 38/91 631/337 631/45/275 631/80 64/60 82/51 Anaphase Apoptosis Biochemistry Biomedical and Life Sciences Cell Biology Cell Cycle Analysis Chromosomes Conformation Dephosphorylation Genomes Kinases Kinesin Life Sciences Localization Phosphorylation Polo-like kinase Polo-like kinase 1 Prophase PTEN protein Stem Cells Tumors
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!