Accuracy of Endoscopic Ultrasonography for Determining the Depth of Invasion in Early Gastric Cancer
Background: Accurate staging for depth of invasion (T stage) of early gastric cancer is critical for determining the treatment modality. Endoscopic ultrasonography is a reliable method for assessing the T stage. However, its diagnostic accuracy varies. The aim of this study is to investigate clinico...
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| Veröffentlicht in: | The Turkish Journal of Gastroenterology 2022-09, Vol.33 (9), p.785-792 |
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| creator | Kim, Seung-Jun Lim, Chul-Hyun Lee, Bo-In |
| description | Background: Accurate staging for depth of invasion (T stage) of early gastric cancer is critical for determining the treatment modality. Endoscopic ultrasonography is a reliable method for assessing the T stage. However, its diagnostic accuracy varies. The aim of this study is to investigate clinicopathologic factors affecting the diagnostic accuracy of endoscopic ultrasonography in early gastric cancer. Methods: Patients with early gastric cancer who had undergone endoscopic resection or gastrectomy were included. The diagnostic accuracy of endoscopic ultrasonography was evaluated by comparing the T stage by endoscopic ultrasonography with histopathology of the resected specimen. Subgroup analysis was performed according to the endoscopic resection criteria. Results: A total of 223 early gastric cancer lesions were included. The overall accuracy of endoscopic ultrasonography for T staging was 66.4%. The diagnostic accuracy for lesions 3 cm (odds ratio 5.47). The diagnostic accuracy was significantly decreased in lesions with ulceration (odds ratio 2.62) or non-flat morphology (odds ratio 2.94). The accuracy of endoscopic ultrasonography for lesions corresponding to the absolute endoscopic resection criteria was significantly higher than for those corresponding to the expanded criteria (97.3% vs 71.9%, P = .002). Of the tumors that were overestimated by endoscopic ultrasonography treated with gastrectomy, 93.3% corresponded to the expanded criteria. Conclusion: Endoscopic ultrasonography had poor accuracy in early gastric cancer lesions larger than 2 cm, those with ulceration, and those with non-flat morphology, that is, lesions corresponding to the expanded criteria were more frequently overstaged by endoscopic ultrasonography. Such early gastric cancers should be carefully considered when staging by endoscopic ultrasonography before gastrectomy. Keywords: Endoscopic mucosal resection, endosonography, gastrectomy, stomach neoplasms |
| doi_str_mv | 10.5152/tjg.2022.21847 |
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Endoscopic ultrasonography is a reliable method for assessing the T stage. However, its diagnostic accuracy varies. The aim of this study is to investigate clinicopathologic factors affecting the diagnostic accuracy of endoscopic ultrasonography in early gastric cancer. Methods: Patients with early gastric cancer who had undergone endoscopic resection or gastrectomy were included. The diagnostic accuracy of endoscopic ultrasonography was evaluated by comparing the T stage by endoscopic ultrasonography with histopathology of the resected specimen. Subgroup analysis was performed according to the endoscopic resection criteria. Results: A total of 223 early gastric cancer lesions were included. The overall accuracy of endoscopic ultrasonography for T staging was 66.4%. The diagnostic accuracy for lesions <2 cm was significantly higher than for those of 2-3 cm (odds ratio 3.59) or those >3 cm (odds ratio 5.47). The diagnostic accuracy was significantly decreased in lesions with ulceration (odds ratio 2.62) or non-flat morphology (odds ratio 2.94). The accuracy of endoscopic ultrasonography for lesions corresponding to the absolute endoscopic resection criteria was significantly higher than for those corresponding to the expanded criteria (97.3% vs 71.9%, P = .002). Of the tumors that were overestimated by endoscopic ultrasonography treated with gastrectomy, 93.3% corresponded to the expanded criteria. Conclusion: Endoscopic ultrasonography had poor accuracy in early gastric cancer lesions larger than 2 cm, those with ulceration, and those with non-flat morphology, that is, lesions corresponding to the expanded criteria were more frequently overstaged by endoscopic ultrasonography. Such early gastric cancers should be carefully considered when staging by endoscopic ultrasonography before gastrectomy. Keywords: Endoscopic mucosal resection, endosonography, gastrectomy, stomach neoplasms</description><identifier>ISSN: 1300-4948</identifier><identifier>EISSN: 2148-5607</identifier><identifier>DOI: 10.5152/tjg.2022.21847</identifier><identifier>PMID: 35946887</identifier><language>eng</language><publisher>AVES</publisher><subject>Cancer ; Diagnosis ; Endoscopic ultrasonography ; Evaluation ; GASTROINTESTINAL ENDOSCOPY ; Methods ; Original ; Stomach cancer ; Tumor staging</subject><ispartof>The Turkish Journal of Gastroenterology, 2022-09, Vol.33 (9), p.785-792</ispartof><rights>COPYRIGHT 2022 AVES</rights><rights>Copyright 2022 authors 2022 authors</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-d4b63af1dda2dc120430fddb101f5047243f61b31f66d176a8e80f65226f8fe83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524487/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9524487/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Kim, Seung-Jun</creatorcontrib><creatorcontrib>Lim, Chul-Hyun</creatorcontrib><creatorcontrib>Lee, Bo-In</creatorcontrib><creatorcontrib>Division of Gastroenterology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea Faculty of Medicine, Seoul, Republic of Korea</creatorcontrib><creatorcontrib>Division of Gastroenterology, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, The Catholic University of Korea Faculty of Medicine, Seoul, Republic of Korea</creatorcontrib><creatorcontrib>Department of Gastroenterology, H Plus Yangji Hospital, Seoul, Republic of Korea</creatorcontrib><title>Accuracy of Endoscopic Ultrasonography for Determining the Depth of Invasion in Early Gastric Cancer</title><title>The Turkish Journal of Gastroenterology</title><description>Background: Accurate staging for depth of invasion (T stage) of early gastric cancer is critical for determining the treatment modality. Endoscopic ultrasonography is a reliable method for assessing the T stage. However, its diagnostic accuracy varies. The aim of this study is to investigate clinicopathologic factors affecting the diagnostic accuracy of endoscopic ultrasonography in early gastric cancer. Methods: Patients with early gastric cancer who had undergone endoscopic resection or gastrectomy were included. The diagnostic accuracy of endoscopic ultrasonography was evaluated by comparing the T stage by endoscopic ultrasonography with histopathology of the resected specimen. Subgroup analysis was performed according to the endoscopic resection criteria. Results: A total of 223 early gastric cancer lesions were included. The overall accuracy of endoscopic ultrasonography for T staging was 66.4%. The diagnostic accuracy for lesions <2 cm was significantly higher than for those of 2-3 cm (odds ratio 3.59) or those >3 cm (odds ratio 5.47). The diagnostic accuracy was significantly decreased in lesions with ulceration (odds ratio 2.62) or non-flat morphology (odds ratio 2.94). The accuracy of endoscopic ultrasonography for lesions corresponding to the absolute endoscopic resection criteria was significantly higher than for those corresponding to the expanded criteria (97.3% vs 71.9%, P = .002). Of the tumors that were overestimated by endoscopic ultrasonography treated with gastrectomy, 93.3% corresponded to the expanded criteria. Conclusion: Endoscopic ultrasonography had poor accuracy in early gastric cancer lesions larger than 2 cm, those with ulceration, and those with non-flat morphology, that is, lesions corresponding to the expanded criteria were more frequently overstaged by endoscopic ultrasonography. Such early gastric cancers should be carefully considered when staging by endoscopic ultrasonography before gastrectomy. Keywords: Endoscopic mucosal resection, endosonography, gastrectomy, stomach neoplasms</description><subject>Cancer</subject><subject>Diagnosis</subject><subject>Endoscopic ultrasonography</subject><subject>Evaluation</subject><subject>GASTROINTESTINAL ENDOSCOPY</subject><subject>Methods</subject><subject>Original</subject><subject>Stomach cancer</subject><subject>Tumor staging</subject><issn>1300-4948</issn><issn>2148-5607</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNqdkktr3DAUhU1paaZpt10buunG06uHZXlTGKbTZCDQTbMWsh4eDbbkSp7A_PvImdAS6CpoIXR1zsfV1SmKzwjWNarxt_nYrzFgvMaI0-ZNscKI8qpm0LwtVogAVLSl_Kr4kNIRgHDE8PviitQtZZw3q0JvlDpFqc5lsOXO65BUmJwq74c5yhR86KOcDufShlj-MLOJo_PO9-V8MPk8zYfFt_cPMrngS-fLnYzDubyRaY4Zs5VemfixeGflkMyn5_26uP-5-729re5-3ey3m7tK1ayZK007RqRFWkusFcJACVitOwTI1kAbTIllqCPIMqZRwyQ3HCyrMWaWW8PJdbG_cHWQRzFFN8p4FkE68VQIsRcyzk4NRkhMSGtxzUnTUkryYDoLWGqQChnWosz6fmFNp240WhmfBzK8gL688e4g-vAg2hpTypsM-PoMiOHPyaRZjC4pMwzSm3BKAjcAjLS0hSz9cpH2MrfmvA2ZqBa52DT5QxlDaOlo_R9VXtqMTgVvrMv11xiAtDVg-GdQMaQUjf37XARiiZvIcRNL3MRT3MgjTsDFVg</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Kim, Seung-Jun</creator><creator>Lim, Chul-Hyun</creator><creator>Lee, Bo-In</creator><general>AVES</general><general>Turkish Society of Gastroenterology</general><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20220901</creationdate><title>Accuracy of Endoscopic Ultrasonography for Determining the Depth of Invasion in Early Gastric Cancer</title><author>Kim, Seung-Jun ; Lim, Chul-Hyun ; Lee, Bo-In</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c567t-d4b63af1dda2dc120430fddb101f5047243f61b31f66d176a8e80f65226f8fe83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cancer</topic><topic>Diagnosis</topic><topic>Endoscopic ultrasonography</topic><topic>Evaluation</topic><topic>GASTROINTESTINAL ENDOSCOPY</topic><topic>Methods</topic><topic>Original</topic><topic>Stomach cancer</topic><topic>Tumor staging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Seung-Jun</creatorcontrib><creatorcontrib>Lim, Chul-Hyun</creatorcontrib><creatorcontrib>Lee, Bo-In</creatorcontrib><creatorcontrib>Division of Gastroenterology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea Faculty of Medicine, Seoul, Republic of Korea</creatorcontrib><creatorcontrib>Division of Gastroenterology, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, The Catholic University of Korea Faculty of Medicine, Seoul, Republic of Korea</creatorcontrib><creatorcontrib>Department of Gastroenterology, H Plus Yangji Hospital, Seoul, Republic of Korea</creatorcontrib><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>The Turkish Journal of Gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Seung-Jun</au><au>Lim, Chul-Hyun</au><au>Lee, Bo-In</au><aucorp>Division of Gastroenterology, Department of Internal Medicine, Seoul St. Mary’s Hospital, The Catholic University of Korea Faculty of Medicine, Seoul, Republic of Korea</aucorp><aucorp>Division of Gastroenterology, Department of Internal Medicine, Eunpyeong St. Mary’s Hospital, The Catholic University of Korea Faculty of Medicine, Seoul, Republic of Korea</aucorp><aucorp>Department of Gastroenterology, H Plus Yangji Hospital, Seoul, Republic of Korea</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Accuracy of Endoscopic Ultrasonography for Determining the Depth of Invasion in Early Gastric Cancer</atitle><jtitle>The Turkish Journal of Gastroenterology</jtitle><date>2022-09-01</date><risdate>2022</risdate><volume>33</volume><issue>9</issue><spage>785</spage><epage>792</epage><pages>785-792</pages><issn>1300-4948</issn><eissn>2148-5607</eissn><abstract>Background: Accurate staging for depth of invasion (T stage) of early gastric cancer is critical for determining the treatment modality. Endoscopic ultrasonography is a reliable method for assessing the T stage. However, its diagnostic accuracy varies. The aim of this study is to investigate clinicopathologic factors affecting the diagnostic accuracy of endoscopic ultrasonography in early gastric cancer. Methods: Patients with early gastric cancer who had undergone endoscopic resection or gastrectomy were included. The diagnostic accuracy of endoscopic ultrasonography was evaluated by comparing the T stage by endoscopic ultrasonography with histopathology of the resected specimen. Subgroup analysis was performed according to the endoscopic resection criteria. Results: A total of 223 early gastric cancer lesions were included. The overall accuracy of endoscopic ultrasonography for T staging was 66.4%. The diagnostic accuracy for lesions <2 cm was significantly higher than for those of 2-3 cm (odds ratio 3.59) or those >3 cm (odds ratio 5.47). The diagnostic accuracy was significantly decreased in lesions with ulceration (odds ratio 2.62) or non-flat morphology (odds ratio 2.94). The accuracy of endoscopic ultrasonography for lesions corresponding to the absolute endoscopic resection criteria was significantly higher than for those corresponding to the expanded criteria (97.3% vs 71.9%, P = .002). Of the tumors that were overestimated by endoscopic ultrasonography treated with gastrectomy, 93.3% corresponded to the expanded criteria. Conclusion: Endoscopic ultrasonography had poor accuracy in early gastric cancer lesions larger than 2 cm, those with ulceration, and those with non-flat morphology, that is, lesions corresponding to the expanded criteria were more frequently overstaged by endoscopic ultrasonography. Such early gastric cancers should be carefully considered when staging by endoscopic ultrasonography before gastrectomy. Keywords: Endoscopic mucosal resection, endosonography, gastrectomy, stomach neoplasms</abstract><pub>AVES</pub><pmid>35946887</pmid><doi>10.5152/tjg.2022.21847</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Cancer Diagnosis Endoscopic ultrasonography Evaluation GASTROINTESTINAL ENDOSCOPY Methods Original Stomach cancer Tumor staging |
| title | Accuracy of Endoscopic Ultrasonography for Determining the Depth of Invasion in Early Gastric Cancer |
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