Loss of RPTPγ primes breast tissue for acid extrusion, promotes malignant transformation and results in early tumour recurrence and shortened survival

Background While cellular metabolism and acidic waste handling accelerate during breast carcinogenesis, temporal patterns of acid–base regulation and underlying molecular mechanisms responding to the tumour microenvironment remain unclear. Methods We explore data from human cohorts and experimentall...

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Veröffentlicht in:	British journal of cancer 2022-10, Vol.127 (7), p.1226-1238
Hauptverfasser:	Sloth, Rasmus A., Axelsen, Trine V., Espejo, Maria Sofia, Toft, Nicolai J., Voss, Ninna C. S., Burton, Mark, Thomassen, Mads, Vahl, Pernille, Boedtkjer, Ebbe
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443 631/67/1347 692/4028/67/1347 Acid-base regulation Animals Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Research Carcinogenesis Cell Transformation, Neoplastic - genetics Drug Resistance Epidemiology Female Genetic transformation Humans Hydrogen-Ion Concentration Malignancy Medical prognosis Mice Mice, Knockout Microenvironments Molecular Medicine Molecular modelling Neoplasm Recurrence, Local Oncology Protein-tyrosine-phosphatase Receptor-Like Protein Tyrosine Phosphatases, Class 5 - physiology Rodents Transgenic mice Tumor Microenvironment Tumors
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