Management and outcome of prenatal absent pulmonary valve syndrome
Objective The purpose of this study was to explore the outcome in fetuses with prenatal diagnosis of absent pulmonary valve syndrome (APVS) on ultrasound imaging. Methods A manual web scraping technique was utilized, where MEDLINE and EMBASE were searched along the combination with other relevant me...
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Veröffentlicht in: | Archives of gynecology and obstetrics 2022-11, Vol.306 (5), p.1449-1454 |
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creator | Recker, Florian Weber, Eva C. Strizek, Brigitte Geipel, Annegret Berg, Christoph Gembruch, Ulrich |
description | Objective
The purpose of this study was to explore the outcome in fetuses with prenatal diagnosis of absent pulmonary valve syndrome (APVS) on ultrasound imaging.
Methods
A manual web scraping technique was utilized, where MEDLINE and EMBASE were searched along the combination with other relevant medical subject headings such as “absent pulmonary valve syndrome”, “prenatal APVS” and “APVS/outcome”. The observed outcomes encompassed the rate of chromosomal abnormalities, associations and malformations linked to APVS and fetuses with APVS. A quality assessment of the included studies was also performed. We used meta-analyses of proportions to combine data and fixed or random-effects models according to the heterogeneity of the results.
Results
Seven studies including 199 fetuses with APVS were included in the analysis. The median gestational age at referral to the tertiary center was 24.8 weeks. An association to tetralogy of Fallot (TOF) could be seen in 84.4% of all cases. In total 140 out of 199 cases underwent invasive testing, with a total number of 55 abnormal karyotypes [39.3% (95% CI 31.1–47.9%)]. 35.2% of the patients opted for termination of pregnancy (95% CI 28.5–42.3%).
Conclusion
The analysis underlines the distribution of fetuses with APVS, with 84.4% of cases presenting with TOF/APVS and only 12.6% having APVS/intact ventricular septum (IVS). Larger and more prospective study analyses is now needed, especially focusing on long-term follow-up periods of fetuses and children with APVS. Particularly as the postnatal course shows great variety depending on prenatal diagnosis. |
doi_str_mv | 10.1007/s00404-022-06397-4 |
format | Article |
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The purpose of this study was to explore the outcome in fetuses with prenatal diagnosis of absent pulmonary valve syndrome (APVS) on ultrasound imaging.
Methods
A manual web scraping technique was utilized, where MEDLINE and EMBASE were searched along the combination with other relevant medical subject headings such as “absent pulmonary valve syndrome”, “prenatal APVS” and “APVS/outcome”. The observed outcomes encompassed the rate of chromosomal abnormalities, associations and malformations linked to APVS and fetuses with APVS. A quality assessment of the included studies was also performed. We used meta-analyses of proportions to combine data and fixed or random-effects models according to the heterogeneity of the results.
Results
Seven studies including 199 fetuses with APVS were included in the analysis. The median gestational age at referral to the tertiary center was 24.8 weeks. An association to tetralogy of Fallot (TOF) could be seen in 84.4% of all cases. In total 140 out of 199 cases underwent invasive testing, with a total number of 55 abnormal karyotypes [39.3% (95% CI 31.1–47.9%)]. 35.2% of the patients opted for termination of pregnancy (95% CI 28.5–42.3%).
Conclusion
The analysis underlines the distribution of fetuses with APVS, with 84.4% of cases presenting with TOF/APVS and only 12.6% having APVS/intact ventricular septum (IVS). Larger and more prospective study analyses is now needed, especially focusing on long-term follow-up periods of fetuses and children with APVS. Particularly as the postnatal course shows great variety depending on prenatal diagnosis.</description><identifier>ISSN: 1432-0711</identifier><identifier>ISSN: 0932-0067</identifier><identifier>EISSN: 1432-0711</identifier><identifier>DOI: 10.1007/s00404-022-06397-4</identifier><identifier>PMID: 35043273</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Cardiovascular disease ; Cohort analysis ; Congenital diseases ; Endocrinology ; Fetuses ; Gestational age ; Gynecology ; Human Genetics ; Maternal-Fetal Medicine ; Medicine ; Medicine & Public Health ; Obstetrics ; Obstetrics/Perinatology/Midwifery ; Pulmonary arteries ; Statistical analysis ; Surgery ; Ultrasonic imaging ; Veins & arteries</subject><ispartof>Archives of gynecology and obstetrics, 2022-11, Vol.306 (5), p.1449-1454</ispartof><rights>The Author(s) 2022</rights><rights>2022. The Author(s).</rights><rights>The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-5271b8d63d92284901d565fc0c02050ba86719646ea90569a110fdc3c7e2b3c43</citedby><cites>FETCH-LOGICAL-c474t-5271b8d63d92284901d565fc0c02050ba86719646ea90569a110fdc3c7e2b3c43</cites><orcidid>0000-0001-9135-4338</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00404-022-06397-4$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00404-022-06397-4$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35043273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Recker, Florian</creatorcontrib><creatorcontrib>Weber, Eva C.</creatorcontrib><creatorcontrib>Strizek, Brigitte</creatorcontrib><creatorcontrib>Geipel, Annegret</creatorcontrib><creatorcontrib>Berg, Christoph</creatorcontrib><creatorcontrib>Gembruch, Ulrich</creatorcontrib><title>Management and outcome of prenatal absent pulmonary valve syndrome</title><title>Archives of gynecology and obstetrics</title><addtitle>Arch Gynecol Obstet</addtitle><addtitle>Arch Gynecol Obstet</addtitle><description>Objective
The purpose of this study was to explore the outcome in fetuses with prenatal diagnosis of absent pulmonary valve syndrome (APVS) on ultrasound imaging.
Methods
A manual web scraping technique was utilized, where MEDLINE and EMBASE were searched along the combination with other relevant medical subject headings such as “absent pulmonary valve syndrome”, “prenatal APVS” and “APVS/outcome”. The observed outcomes encompassed the rate of chromosomal abnormalities, associations and malformations linked to APVS and fetuses with APVS. A quality assessment of the included studies was also performed. We used meta-analyses of proportions to combine data and fixed or random-effects models according to the heterogeneity of the results.
Results
Seven studies including 199 fetuses with APVS were included in the analysis. The median gestational age at referral to the tertiary center was 24.8 weeks. An association to tetralogy of Fallot (TOF) could be seen in 84.4% of all cases. In total 140 out of 199 cases underwent invasive testing, with a total number of 55 abnormal karyotypes [39.3% (95% CI 31.1–47.9%)]. 35.2% of the patients opted for termination of pregnancy (95% CI 28.5–42.3%).
Conclusion
The analysis underlines the distribution of fetuses with APVS, with 84.4% of cases presenting with TOF/APVS and only 12.6% having APVS/intact ventricular septum (IVS). Larger and more prospective study analyses is now needed, especially focusing on long-term follow-up periods of fetuses and children with APVS. Particularly as the postnatal course shows great variety depending on prenatal diagnosis.</description><subject>Cardiovascular disease</subject><subject>Cohort analysis</subject><subject>Congenital diseases</subject><subject>Endocrinology</subject><subject>Fetuses</subject><subject>Gestational age</subject><subject>Gynecology</subject><subject>Human Genetics</subject><subject>Maternal-Fetal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Obstetrics</subject><subject>Obstetrics/Perinatology/Midwifery</subject><subject>Pulmonary arteries</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Ultrasonic imaging</subject><subject>Veins & arteries</subject><issn>1432-0711</issn><issn>0932-0067</issn><issn>1432-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kTtPwzAUhS0EoqXwBxhQJBaWwPUjdrIgQcVLKmKB2XIcpxQldrGTSv33uLSUx8BkW-fz8T0-CB1jOMcA4iIAMGApEJICp4VI2Q4aYkbjUWC8-2M_QAchvAFgkud8Hw1oBlESdIiuH5VVU9Ma2yXKVonrO-1ak7g6mXtjVaeaRJVhJc_7pnVW-WWyUM3CJGFpKx_ZQ7RXqyaYo806Qi-3N8_j-3TydPcwvpqkmgnWpRkRuMwrTquCkJwVgKuMZ7UGDQQyKFXOBS4440YVkPFCYQx1pakWhpRUMzpCl2vfeV-2ptJxJq8aOfezNg4lnZrJ34qdvcqpW8giw4WIaUfobGPg3XtvQifbWdCmaZQ1rg-ScIJJFr8TInr6B31zvbcxnowxcsGiI40UWVPauxC8qbfDYJCriuS6Ihk95WdFchXj5GeM7ZWvTiJA10CIkp0a__32P7YfSnmbkg</recordid><startdate>20221101</startdate><enddate>20221101</enddate><creator>Recker, Florian</creator><creator>Weber, Eva C.</creator><creator>Strizek, Brigitte</creator><creator>Geipel, Annegret</creator><creator>Berg, Christoph</creator><creator>Gembruch, Ulrich</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9135-4338</orcidid></search><sort><creationdate>20221101</creationdate><title>Management and outcome of prenatal absent pulmonary valve syndrome</title><author>Recker, Florian ; Weber, Eva C. ; Strizek, Brigitte ; Geipel, Annegret ; Berg, Christoph ; Gembruch, Ulrich</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-5271b8d63d92284901d565fc0c02050ba86719646ea90569a110fdc3c7e2b3c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cardiovascular disease</topic><topic>Cohort analysis</topic><topic>Congenital diseases</topic><topic>Endocrinology</topic><topic>Fetuses</topic><topic>Gestational age</topic><topic>Gynecology</topic><topic>Human Genetics</topic><topic>Maternal-Fetal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Obstetrics</topic><topic>Obstetrics/Perinatology/Midwifery</topic><topic>Pulmonary arteries</topic><topic>Statistical analysis</topic><topic>Surgery</topic><topic>Ultrasonic imaging</topic><topic>Veins & arteries</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Recker, Florian</creatorcontrib><creatorcontrib>Weber, Eva C.</creatorcontrib><creatorcontrib>Strizek, Brigitte</creatorcontrib><creatorcontrib>Geipel, Annegret</creatorcontrib><creatorcontrib>Berg, Christoph</creatorcontrib><creatorcontrib>Gembruch, Ulrich</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Archives of gynecology and obstetrics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Recker, Florian</au><au>Weber, Eva C.</au><au>Strizek, Brigitte</au><au>Geipel, Annegret</au><au>Berg, Christoph</au><au>Gembruch, Ulrich</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management and outcome of prenatal absent pulmonary valve syndrome</atitle><jtitle>Archives of gynecology and obstetrics</jtitle><stitle>Arch Gynecol Obstet</stitle><addtitle>Arch Gynecol Obstet</addtitle><date>2022-11-01</date><risdate>2022</risdate><volume>306</volume><issue>5</issue><spage>1449</spage><epage>1454</epage><pages>1449-1454</pages><issn>1432-0711</issn><issn>0932-0067</issn><eissn>1432-0711</eissn><abstract>Objective
The purpose of this study was to explore the outcome in fetuses with prenatal diagnosis of absent pulmonary valve syndrome (APVS) on ultrasound imaging.
Methods
A manual web scraping technique was utilized, where MEDLINE and EMBASE were searched along the combination with other relevant medical subject headings such as “absent pulmonary valve syndrome”, “prenatal APVS” and “APVS/outcome”. The observed outcomes encompassed the rate of chromosomal abnormalities, associations and malformations linked to APVS and fetuses with APVS. A quality assessment of the included studies was also performed. We used meta-analyses of proportions to combine data and fixed or random-effects models according to the heterogeneity of the results.
Results
Seven studies including 199 fetuses with APVS were included in the analysis. The median gestational age at referral to the tertiary center was 24.8 weeks. An association to tetralogy of Fallot (TOF) could be seen in 84.4% of all cases. In total 140 out of 199 cases underwent invasive testing, with a total number of 55 abnormal karyotypes [39.3% (95% CI 31.1–47.9%)]. 35.2% of the patients opted for termination of pregnancy (95% CI 28.5–42.3%).
Conclusion
The analysis underlines the distribution of fetuses with APVS, with 84.4% of cases presenting with TOF/APVS and only 12.6% having APVS/intact ventricular septum (IVS). Larger and more prospective study analyses is now needed, especially focusing on long-term follow-up periods of fetuses and children with APVS. Particularly as the postnatal course shows great variety depending on prenatal diagnosis.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>35043273</pmid><doi>10.1007/s00404-022-06397-4</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-9135-4338</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Cardiovascular disease Cohort analysis Congenital diseases Endocrinology Fetuses Gestational age Gynecology Human Genetics Maternal-Fetal Medicine Medicine Medicine & Public Health Obstetrics Obstetrics/Perinatology/Midwifery Pulmonary arteries Statistical analysis Surgery Ultrasonic imaging Veins & arteries |
title | Management and outcome of prenatal absent pulmonary valve syndrome |
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