Comparative Quality Assessment of Five Bread Wheat and Five Barley Cultivars Grown in Romania

Cereals whole grains contain vitamins, phytochemicals, antioxidants, resistant starch, and minerals with potential benefits to human health. The consumption of whole grains is correlated with a lowered risk of the most important chronic diseases, including type II diabetes, cardiovascular diseases,...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of environmental research and public health 2022-09, Vol.19 (17), p.11114
Hauptverfasser: Moroșan, Elena, Secareanu, Ana Andreea, Musuc, Adina Magdalena, Mititelu, Magdalena, Ioniță, Ana Corina, Ozon, Emma Adriana, Raducan, Ionuț Daniel, Rusu, Andreea Ioana, Dărăban, Adriana Maria, Karampelas, Oana
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 17
container_start_page 11114
container_title International journal of environmental research and public health
container_volume 19
creator Moroșan, Elena
Secareanu, Ana Andreea
Musuc, Adina Magdalena
Mititelu, Magdalena
Ioniță, Ana Corina
Ozon, Emma Adriana
Raducan, Ionuț Daniel
Rusu, Andreea Ioana
Dărăban, Adriana Maria
Karampelas, Oana
description Cereals whole grains contain vitamins, phytochemicals, antioxidants, resistant starch, and minerals with potential benefits to human health. The consumption of whole grains is correlated with a lowered risk of the most important chronic diseases, including type II diabetes, cardiovascular diseases, and some cancers. This study aimed to characterize and evaluate the content of five cultivars of wheat ( L.) and five cultivars of barley ( L.) obtained by conventional plant breeding using crossing and selection methods. The novelty and the purpose of this research was to quantitatively and qualitatively analyze these ten cultivars from Romania and to show the importance of, and the changes produced by, crossing and selection methods when these are aimed at the physiological or morphological development of the cultivars. Studies based on gluten dosing; spectrophotometry using Bradford, fructan and protein dosing; Kjeldahl protein dosing; GC-MS/MS-protein and amino acid dosing; and identification of protein fractions using polyacrylamide gel electrophoretic method were conducted. This study demonstrates the possibility of developing future cultivars using conventional methods of improvement to modify the content and composition of nutrients to increase their health benefits.
doi_str_mv 10.3390/ijerph191711114
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9517766</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2711315412</sourcerecordid><originalsourceid>FETCH-LOGICAL-c421t-889bb933c47209cc77a62062b1c687e8736d8714251c5864c692c5fd826cfcb73</originalsourceid><addsrcrecordid>eNpdkU1LAzEQhoMotlbP3iTgxUttPnaT7EWoxVahIIriSUI2m7Upu5ua7Fb6793SWmrnMsPMMy8zvABcYnRLaYIGdm78YoYTzHEb0RHoYsZQP2IIH-_VHXAWwhwhKiKWnIIOZYgLQVEXfI5cuVBe1XZp4EujCluv4DAEE0Jpqhq6HI7Xo3tvVAY_ZkbVUFXZtql8YVZw1BTtuvIBTrz7qaCt4KsrVWXVOTjJVRHMxTb3wPv44W302J8-T55Gw2lfRwTXfSGSNE0o1REnKNGac8UIYiTFmgluBKcsExxHJMY6FizSLCE6zjNBmM51ymkP3G10F01amky3l3tVyIW3pfIr6ZSV_yeVnckvt5RJjDlnrBW42Qp4992YUMvSBm2KQlXGNUESjolYs6hFrw_QuWt81b63pjDFcYRJSw02lPYuBG_y3TEYybV18sC6duNq_4cd_-cV_QW4zpUu</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2711315412</pqid></control><display><type>article</type><title>Comparative Quality Assessment of Five Bread Wheat and Five Barley Cultivars Grown in Romania</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Moroșan, Elena ; Secareanu, Ana Andreea ; Musuc, Adina Magdalena ; Mititelu, Magdalena ; Ioniță, Ana Corina ; Ozon, Emma Adriana ; Raducan, Ionuț Daniel ; Rusu, Andreea Ioana ; Dărăban, Adriana Maria ; Karampelas, Oana</creator><creatorcontrib>Moroșan, Elena ; Secareanu, Ana Andreea ; Musuc, Adina Magdalena ; Mititelu, Magdalena ; Ioniță, Ana Corina ; Ozon, Emma Adriana ; Raducan, Ionuț Daniel ; Rusu, Andreea Ioana ; Dărăban, Adriana Maria ; Karampelas, Oana</creatorcontrib><description>Cereals whole grains contain vitamins, phytochemicals, antioxidants, resistant starch, and minerals with potential benefits to human health. The consumption of whole grains is correlated with a lowered risk of the most important chronic diseases, including type II diabetes, cardiovascular diseases, and some cancers. This study aimed to characterize and evaluate the content of five cultivars of wheat ( L.) and five cultivars of barley ( L.) obtained by conventional plant breeding using crossing and selection methods. The novelty and the purpose of this research was to quantitatively and qualitatively analyze these ten cultivars from Romania and to show the importance of, and the changes produced by, crossing and selection methods when these are aimed at the physiological or morphological development of the cultivars. Studies based on gluten dosing; spectrophotometry using Bradford, fructan and protein dosing; Kjeldahl protein dosing; GC-MS/MS-protein and amino acid dosing; and identification of protein fractions using polyacrylamide gel electrophoretic method were conducted. This study demonstrates the possibility of developing future cultivars using conventional methods of improvement to modify the content and composition of nutrients to increase their health benefits.</description><identifier>ISSN: 1660-4601</identifier><identifier>ISSN: 1661-7827</identifier><identifier>EISSN: 1660-4601</identifier><identifier>DOI: 10.3390/ijerph191711114</identifier><identifier>PMID: 36078830</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Agricultural research ; Amino acids ; Bakeries ; Barley ; Bread ; Breweries ; Carbohydrates ; Cardiovascular diseases ; Cereals ; Crop diseases ; Cultivars ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 ; Dietary minerals ; Dosage ; Flour ; Food products ; Gluten ; Hordeum - chemistry ; Humans ; Methods ; Mineralization ; Minerals ; Nitrogen ; Nutrients ; Plant Breeding ; Polyacrylamide ; Proteins ; Quality assessment ; Quality control ; R&amp;D ; Research &amp; development ; Romania ; Seeds ; Spectrophotometry ; Tandem Mass Spectrometry ; Triticum - chemistry ; Vitamins ; Wheat</subject><ispartof>International journal of environmental research and public health, 2022-09, Vol.19 (17), p.11114</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-889bb933c47209cc77a62062b1c687e8736d8714251c5864c692c5fd826cfcb73</citedby><cites>FETCH-LOGICAL-c421t-889bb933c47209cc77a62062b1c687e8736d8714251c5864c692c5fd826cfcb73</cites><orcidid>0000-0002-6935-8065 ; 0000-0002-8448-5054</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517766/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9517766/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36078830$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moroșan, Elena</creatorcontrib><creatorcontrib>Secareanu, Ana Andreea</creatorcontrib><creatorcontrib>Musuc, Adina Magdalena</creatorcontrib><creatorcontrib>Mititelu, Magdalena</creatorcontrib><creatorcontrib>Ioniță, Ana Corina</creatorcontrib><creatorcontrib>Ozon, Emma Adriana</creatorcontrib><creatorcontrib>Raducan, Ionuț Daniel</creatorcontrib><creatorcontrib>Rusu, Andreea Ioana</creatorcontrib><creatorcontrib>Dărăban, Adriana Maria</creatorcontrib><creatorcontrib>Karampelas, Oana</creatorcontrib><title>Comparative Quality Assessment of Five Bread Wheat and Five Barley Cultivars Grown in Romania</title><title>International journal of environmental research and public health</title><addtitle>Int J Environ Res Public Health</addtitle><description>Cereals whole grains contain vitamins, phytochemicals, antioxidants, resistant starch, and minerals with potential benefits to human health. The consumption of whole grains is correlated with a lowered risk of the most important chronic diseases, including type II diabetes, cardiovascular diseases, and some cancers. This study aimed to characterize and evaluate the content of five cultivars of wheat ( L.) and five cultivars of barley ( L.) obtained by conventional plant breeding using crossing and selection methods. The novelty and the purpose of this research was to quantitatively and qualitatively analyze these ten cultivars from Romania and to show the importance of, and the changes produced by, crossing and selection methods when these are aimed at the physiological or morphological development of the cultivars. Studies based on gluten dosing; spectrophotometry using Bradford, fructan and protein dosing; Kjeldahl protein dosing; GC-MS/MS-protein and amino acid dosing; and identification of protein fractions using polyacrylamide gel electrophoretic method were conducted. This study demonstrates the possibility of developing future cultivars using conventional methods of improvement to modify the content and composition of nutrients to increase their health benefits.</description><subject>Agricultural research</subject><subject>Amino acids</subject><subject>Bakeries</subject><subject>Barley</subject><subject>Bread</subject><subject>Breweries</subject><subject>Carbohydrates</subject><subject>Cardiovascular diseases</subject><subject>Cereals</subject><subject>Crop diseases</subject><subject>Cultivars</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Type 2</subject><subject>Dietary minerals</subject><subject>Dosage</subject><subject>Flour</subject><subject>Food products</subject><subject>Gluten</subject><subject>Hordeum - chemistry</subject><subject>Humans</subject><subject>Methods</subject><subject>Mineralization</subject><subject>Minerals</subject><subject>Nitrogen</subject><subject>Nutrients</subject><subject>Plant Breeding</subject><subject>Polyacrylamide</subject><subject>Proteins</subject><subject>Quality assessment</subject><subject>Quality control</subject><subject>R&amp;D</subject><subject>Research &amp; development</subject><subject>Romania</subject><subject>Seeds</subject><subject>Spectrophotometry</subject><subject>Tandem Mass Spectrometry</subject><subject>Triticum - chemistry</subject><subject>Vitamins</subject><subject>Wheat</subject><issn>1660-4601</issn><issn>1661-7827</issn><issn>1660-4601</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkU1LAzEQhoMotlbP3iTgxUttPnaT7EWoxVahIIriSUI2m7Upu5ua7Fb6793SWmrnMsPMMy8zvABcYnRLaYIGdm78YoYTzHEb0RHoYsZQP2IIH-_VHXAWwhwhKiKWnIIOZYgLQVEXfI5cuVBe1XZp4EujCluv4DAEE0Jpqhq6HI7Xo3tvVAY_ZkbVUFXZtql8YVZw1BTtuvIBTrz7qaCt4KsrVWXVOTjJVRHMxTb3wPv44W302J8-T55Gw2lfRwTXfSGSNE0o1REnKNGac8UIYiTFmgluBKcsExxHJMY6FizSLCE6zjNBmM51ymkP3G10F01amky3l3tVyIW3pfIr6ZSV_yeVnckvt5RJjDlnrBW42Qp4992YUMvSBm2KQlXGNUESjolYs6hFrw_QuWt81b63pjDFcYRJSw02lPYuBG_y3TEYybV18sC6duNq_4cd_-cV_QW4zpUu</recordid><startdate>20220905</startdate><enddate>20220905</enddate><creator>Moroșan, Elena</creator><creator>Secareanu, Ana Andreea</creator><creator>Musuc, Adina Magdalena</creator><creator>Mititelu, Magdalena</creator><creator>Ioniță, Ana Corina</creator><creator>Ozon, Emma Adriana</creator><creator>Raducan, Ionuț Daniel</creator><creator>Rusu, Andreea Ioana</creator><creator>Dărăban, Adriana Maria</creator><creator>Karampelas, Oana</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>COVID</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-6935-8065</orcidid><orcidid>https://orcid.org/0000-0002-8448-5054</orcidid></search><sort><creationdate>20220905</creationdate><title>Comparative Quality Assessment of Five Bread Wheat and Five Barley Cultivars Grown in Romania</title><author>Moroșan, Elena ; Secareanu, Ana Andreea ; Musuc, Adina Magdalena ; Mititelu, Magdalena ; Ioniță, Ana Corina ; Ozon, Emma Adriana ; Raducan, Ionuț Daniel ; Rusu, Andreea Ioana ; Dărăban, Adriana Maria ; Karampelas, Oana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-889bb933c47209cc77a62062b1c687e8736d8714251c5864c692c5fd826cfcb73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Agricultural research</topic><topic>Amino acids</topic><topic>Bakeries</topic><topic>Barley</topic><topic>Bread</topic><topic>Breweries</topic><topic>Carbohydrates</topic><topic>Cardiovascular diseases</topic><topic>Cereals</topic><topic>Crop diseases</topic><topic>Cultivars</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Type 2</topic><topic>Dietary minerals</topic><topic>Dosage</topic><topic>Flour</topic><topic>Food products</topic><topic>Gluten</topic><topic>Hordeum - chemistry</topic><topic>Humans</topic><topic>Methods</topic><topic>Mineralization</topic><topic>Minerals</topic><topic>Nitrogen</topic><topic>Nutrients</topic><topic>Plant Breeding</topic><topic>Polyacrylamide</topic><topic>Proteins</topic><topic>Quality assessment</topic><topic>Quality control</topic><topic>R&amp;D</topic><topic>Research &amp; development</topic><topic>Romania</topic><topic>Seeds</topic><topic>Spectrophotometry</topic><topic>Tandem Mass Spectrometry</topic><topic>Triticum - chemistry</topic><topic>Vitamins</topic><topic>Wheat</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moroșan, Elena</creatorcontrib><creatorcontrib>Secareanu, Ana Andreea</creatorcontrib><creatorcontrib>Musuc, Adina Magdalena</creatorcontrib><creatorcontrib>Mititelu, Magdalena</creatorcontrib><creatorcontrib>Ioniță, Ana Corina</creatorcontrib><creatorcontrib>Ozon, Emma Adriana</creatorcontrib><creatorcontrib>Raducan, Ionuț Daniel</creatorcontrib><creatorcontrib>Rusu, Andreea Ioana</creatorcontrib><creatorcontrib>Dărăban, Adriana Maria</creatorcontrib><creatorcontrib>Karampelas, Oana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Coronavirus Research Database</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of environmental research and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moroșan, Elena</au><au>Secareanu, Ana Andreea</au><au>Musuc, Adina Magdalena</au><au>Mititelu, Magdalena</au><au>Ioniță, Ana Corina</au><au>Ozon, Emma Adriana</au><au>Raducan, Ionuț Daniel</au><au>Rusu, Andreea Ioana</au><au>Dărăban, Adriana Maria</au><au>Karampelas, Oana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative Quality Assessment of Five Bread Wheat and Five Barley Cultivars Grown in Romania</atitle><jtitle>International journal of environmental research and public health</jtitle><addtitle>Int J Environ Res Public Health</addtitle><date>2022-09-05</date><risdate>2022</risdate><volume>19</volume><issue>17</issue><spage>11114</spage><pages>11114-</pages><issn>1660-4601</issn><issn>1661-7827</issn><eissn>1660-4601</eissn><abstract>Cereals whole grains contain vitamins, phytochemicals, antioxidants, resistant starch, and minerals with potential benefits to human health. The consumption of whole grains is correlated with a lowered risk of the most important chronic diseases, including type II diabetes, cardiovascular diseases, and some cancers. This study aimed to characterize and evaluate the content of five cultivars of wheat ( L.) and five cultivars of barley ( L.) obtained by conventional plant breeding using crossing and selection methods. The novelty and the purpose of this research was to quantitatively and qualitatively analyze these ten cultivars from Romania and to show the importance of, and the changes produced by, crossing and selection methods when these are aimed at the physiological or morphological development of the cultivars. Studies based on gluten dosing; spectrophotometry using Bradford, fructan and protein dosing; Kjeldahl protein dosing; GC-MS/MS-protein and amino acid dosing; and identification of protein fractions using polyacrylamide gel electrophoretic method were conducted. This study demonstrates the possibility of developing future cultivars using conventional methods of improvement to modify the content and composition of nutrients to increase their health benefits.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>36078830</pmid><doi>10.3390/ijerph191711114</doi><orcidid>https://orcid.org/0000-0002-6935-8065</orcidid><orcidid>https://orcid.org/0000-0002-8448-5054</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1660-4601
ispartof International journal of environmental research and public health, 2022-09, Vol.19 (17), p.11114
issn 1660-4601
1661-7827
1660-4601
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9517766
source MEDLINE; PubMed Central Open Access; MDPI - Multidisciplinary Digital Publishing Institute; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry
subjects Agricultural research
Amino acids
Bakeries
Barley
Bread
Breweries
Carbohydrates
Cardiovascular diseases
Cereals
Crop diseases
Cultivars
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2
Dietary minerals
Dosage
Flour
Food products
Gluten
Hordeum - chemistry
Humans
Methods
Mineralization
Minerals
Nitrogen
Nutrients
Plant Breeding
Polyacrylamide
Proteins
Quality assessment
Quality control
R&D
Research & development
Romania
Seeds
Spectrophotometry
Tandem Mass Spectrometry
Triticum - chemistry
Vitamins
Wheat
title Comparative Quality Assessment of Five Bread Wheat and Five Barley Cultivars Grown in Romania
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T02%3A17%3A18IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20Quality%20Assessment%20of%20Five%20Bread%20Wheat%20and%20Five%20Barley%20Cultivars%20Grown%20in%20Romania&rft.jtitle=International%20journal%20of%20environmental%20research%20and%20public%20health&rft.au=Moro%C8%99an,%20Elena&rft.date=2022-09-05&rft.volume=19&rft.issue=17&rft.spage=11114&rft.pages=11114-&rft.issn=1660-4601&rft.eissn=1660-4601&rft_id=info:doi/10.3390/ijerph191711114&rft_dat=%3Cproquest_pubme%3E2711315412%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2711315412&rft_id=info:pmid/36078830&rfr_iscdi=true