Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations
Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and m...
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| Veröffentlicht in: | International journal of environmental research and public health 2022-09, Vol.19 (18), p.11207 |
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| creator | De Bie, Felix Rafael Basurto, David Kumar, Sailesh Deprest, Jan Russo, Francesca Maria |
| description | Sildenafil, a phosphodiesterase 5 inhibitor with a vasodilatory and anti-remodeling effect, has been investigated concerning various conditions during pregnancy. Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and meta-analyses, when available. Indications for using sildenafil during the second and third trimester of pregnancy include maternal pulmonary hypertension, preeclampsia, preterm labor, fetal growth restriction, oligohydramnios, fetal distress, and congenital diaphragmatic hernia. For most indications, the rationale for administering prenatal sildenafil is based on limited, equivocal data from in vitro studies and rodent disease models. Clinical studies report mild maternal side effects and suggest good fetal tolerance and safety depending on the underlying pathology. |
| doi_str_mv | 10.3390/ijerph191811207 |
| format | Article |
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Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and meta-analyses, when available. Indications for using sildenafil during the second and third trimester of pregnancy include maternal pulmonary hypertension, preeclampsia, preterm labor, fetal growth restriction, oligohydramnios, fetal distress, and congenital diaphragmatic hernia. For most indications, the rationale for administering prenatal sildenafil is based on limited, equivocal data from in vitro studies and rodent disease models. 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Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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Per indication, we herein review the rationale and the most relevant experimental and clinical studies, including systematic reviews and meta-analyses, when available. Indications for using sildenafil during the second and third trimester of pregnancy include maternal pulmonary hypertension, preeclampsia, preterm labor, fetal growth restriction, oligohydramnios, fetal distress, and congenital diaphragmatic hernia. For most indications, the rationale for administering prenatal sildenafil is based on limited, equivocal data from in vitro studies and rodent disease models. 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| ispartof | International journal of environmental research and public health, 2022-09, Vol.19 (18), p.11207 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry; PubMed Central Open Access |
| subjects | Angina pectoris Animal models Blood pressure Clinical trials Endothelium Enzymes Female Fetal Growth Retardation Fetuses Hernia Hernias, Diaphragmatic, Congenital - chemically induced Hernias, Diaphragmatic, Congenital - drug therapy Humans Hypertension Hypertension, Pulmonary Kinases Mortality Nitric oxide Phosphodiesterase Phosphodiesterase 5 Inhibitors - pharmacology Phosphodiesterase 5 Inhibitors - therapeutic use Pre-eclampsia Pre-Eclampsia - chemically induced Preeclampsia Pregnancy Pulmonary hypertension Review Sildenafil Sildenafil Citrate - pharmacology Sildenafil Citrate - therapeutic use Smooth muscle Veins & arteries |
| title | Sildenafil during the 2nd and 3rd Trimester of Pregnancy: Trials and Tribulations |
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