Arabidopsis ERdj3B coordinates with ERECTA-family receptor kinases to regulate ovule development and the heat stress response
The endoplasmic reticulum-localized DnaJ family 3B (ERdj3B), is a component of the stromal cell-derived factor 2 (SDF2)-ERdj3B-binding immunoglobulin protein (BiP) chaperone complex, which functions in protein folding, translocation, and quality control. We found that ERdj3B mutations affected integ...
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Veröffentlicht in: | The Plant cell 2022-09, Vol.34 (10), p.3665-3684 |
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creator | Leng, Ya-Jun Yao, Ya-Sen Yang, Ke-Zhen Wu, Pei-Xiang Xia, Yu-Xin Zuo, Chao-Ran Luo, Jing-Hong Wang, Pu Liu, Yang-Yang Zhang, Xue-Qin Ye, De Le, Jie Chen, Li-Qun |
description | The endoplasmic reticulum-localized DnaJ family 3B (ERdj3B), is a component of the stromal cell-derived factor 2 (SDF2)-ERdj3B-binding immunoglobulin protein (BiP) chaperone complex, which functions in protein folding, translocation, and quality control. We found that ERdj3B mutations affected integument development in the Ler ecotype but not in the Col-0 ecotype of Arabidopsis (Arabidopsis thaliana). Map-based cloning identified the ERECTA (ER) gene as a natural modifier of ERdj3B. The double mutation of ERdj3B and ER caused a major defect in the inner integument under heat stress. Additional mutation of the ER paralog ERECTA-LIKE 1 (ERL1) or ERL2 to the erdj3b er double mutant exacerbated the defective integument phenotype. The double mutation of ER and SDF2, the other component of the SDF2-ERdj3B-BiP complex, resulted in similar defects in the inner integument. Furthermore, both the protein abundance and plasma membrane partitioning of ER, ERL1, and ERL2 were markedly reduced in erdj3b plants, indicating that the SDF2-ERdj3B-BiP chaperone complex might control the translocation of ERECTA-family proteins from the endoplasmic reticulum to the plasma membrane. Our results suggest that the SDF2-ERdj3B-BiP complex functions in ovule development and the heat stress response in coordination with ERECTA-family receptor kinases. |
doi_str_mv | 10.1093/plcell/koac226 |
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We found that ERdj3B mutations affected integument development in the Ler ecotype but not in the Col-0 ecotype of Arabidopsis (Arabidopsis thaliana). Map-based cloning identified the ERECTA (ER) gene as a natural modifier of ERdj3B. The double mutation of ERdj3B and ER caused a major defect in the inner integument under heat stress. Additional mutation of the ER paralog ERECTA-LIKE 1 (ERL1) or ERL2 to the erdj3b er double mutant exacerbated the defective integument phenotype. The double mutation of ER and SDF2, the other component of the SDF2-ERdj3B-BiP complex, resulted in similar defects in the inner integument. Furthermore, both the protein abundance and plasma membrane partitioning of ER, ERL1, and ERL2 were markedly reduced in erdj3b plants, indicating that the SDF2-ERdj3B-BiP chaperone complex might control the translocation of ERECTA-family proteins from the endoplasmic reticulum to the plasma membrane. Our results suggest that the SDF2-ERdj3B-BiP complex functions in ovule development and the heat stress response in coordination with ERECTA-family receptor kinases.</description><identifier>ISSN: 1040-4651</identifier><identifier>EISSN: 1532-298X</identifier><identifier>DOI: 10.1093/plcell/koac226</identifier><identifier>PMID: 35897146</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Arabidopsis - metabolism ; Arabidopsis Proteins - genetics ; Arabidopsis Proteins - metabolism ; Carrier Proteins - metabolism ; Heat-Shock Response ; HSP40 Heat-Shock Proteins - metabolism ; Ovule - metabolism ; Protein Serine-Threonine Kinases</subject><ispartof>The Plant cell, 2022-09, Vol.34 (10), p.3665-3684</ispartof><rights>American Society of Plant Biologists 2022. All rights reserved. For permissions, please email: journals.permissions@oup.com.</rights><rights>American Society of Plant Biologists 2022. All rights reserved. For permissions, please email: journals.permissions@oup.com 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c390t-aeed0250c85464f0648415b0887c0582908d2a22a07c17890d061904161bfb553</citedby><cites>FETCH-LOGICAL-c390t-aeed0250c85464f0648415b0887c0582908d2a22a07c17890d061904161bfb553</cites><orcidid>0000-0002-8698-210X ; 0000-0001-9167-4331 ; 0000-0001-9621-8837 ; 0000-0001-8854-3031 ; 0000-0001-7053-1083 ; 0000-0001-5958-6972 ; 0000-0003-4953-1809 ; 0000-0002-9875-3339 ; 0000-0002-8179-6172 ; 0000-0002-6775-8946 ; 0000-0002-4346-1451 ; 0000-0001-8291-3273 ; 0000-0003-1988-3598</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35897146$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leng, Ya-Jun</creatorcontrib><creatorcontrib>Yao, Ya-Sen</creatorcontrib><creatorcontrib>Yang, Ke-Zhen</creatorcontrib><creatorcontrib>Wu, Pei-Xiang</creatorcontrib><creatorcontrib>Xia, Yu-Xin</creatorcontrib><creatorcontrib>Zuo, Chao-Ran</creatorcontrib><creatorcontrib>Luo, Jing-Hong</creatorcontrib><creatorcontrib>Wang, Pu</creatorcontrib><creatorcontrib>Liu, Yang-Yang</creatorcontrib><creatorcontrib>Zhang, Xue-Qin</creatorcontrib><creatorcontrib>Ye, De</creatorcontrib><creatorcontrib>Le, Jie</creatorcontrib><creatorcontrib>Chen, Li-Qun</creatorcontrib><title>Arabidopsis ERdj3B coordinates with ERECTA-family receptor kinases to regulate ovule development and the heat stress response</title><title>The Plant cell</title><addtitle>Plant Cell</addtitle><description>The endoplasmic reticulum-localized DnaJ family 3B (ERdj3B), is a component of the stromal cell-derived factor 2 (SDF2)-ERdj3B-binding immunoglobulin protein (BiP) chaperone complex, which functions in protein folding, translocation, and quality control. We found that ERdj3B mutations affected integument development in the Ler ecotype but not in the Col-0 ecotype of Arabidopsis (Arabidopsis thaliana). Map-based cloning identified the ERECTA (ER) gene as a natural modifier of ERdj3B. The double mutation of ERdj3B and ER caused a major defect in the inner integument under heat stress. Additional mutation of the ER paralog ERECTA-LIKE 1 (ERL1) or ERL2 to the erdj3b er double mutant exacerbated the defective integument phenotype. The double mutation of ER and SDF2, the other component of the SDF2-ERdj3B-BiP complex, resulted in similar defects in the inner integument. Furthermore, both the protein abundance and plasma membrane partitioning of ER, ERL1, and ERL2 were markedly reduced in erdj3b plants, indicating that the SDF2-ERdj3B-BiP chaperone complex might control the translocation of ERECTA-family proteins from the endoplasmic reticulum to the plasma membrane. Our results suggest that the SDF2-ERdj3B-BiP complex functions in ovule development and the heat stress response in coordination with ERECTA-family receptor kinases.</description><subject>Arabidopsis - metabolism</subject><subject>Arabidopsis Proteins - genetics</subject><subject>Arabidopsis Proteins - metabolism</subject><subject>Carrier Proteins - metabolism</subject><subject>Heat-Shock Response</subject><subject>HSP40 Heat-Shock Proteins - metabolism</subject><subject>Ovule - metabolism</subject><subject>Protein Serine-Threonine Kinases</subject><issn>1040-4651</issn><issn>1532-298X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkUFr3DAQhU1paNK01x6Ljr04GcmWLF0K22XbFAKBkkJvQpbGWSe25Uryhhz636uwm5CcZpj55s0wryg-UTijoKrzebA4DOd33ljGxJvihPKKlUzJP29zDjWUteD0uHgf4y0A0Iaqd8VxxaVqaC1Oin-rYNre-Tn2kWx-udvqG7HeB9dPJmEk933a5vpmfb0qOzP2wwMJaHFOPpC7zMTMJJ9rN8uQB4jfLQMShzsc_DzilIiZHElbJFs0icQUMMaMx9lPET8UR50ZIn48xNPi9_fN9fqivLz68XO9uixtpSCVBtEB42Alr0XdgahlTXkLUjYWuGQKpGOGMQONpY1U4EBQBTUVtO1azqvT4uted17aEZ3NdwUz6Dn0owkP2ptev-5M_Vbf-J1WnAqoIAt8OQgE_3fBmPTYx8fPmwn9EjUTSgCIRqiMnu1RG3yMAbvnNRT0o2d675k-eJYHPr887hl_Mqn6Dx59lvY</recordid><startdate>20220927</startdate><enddate>20220927</enddate><creator>Leng, Ya-Jun</creator><creator>Yao, Ya-Sen</creator><creator>Yang, Ke-Zhen</creator><creator>Wu, Pei-Xiang</creator><creator>Xia, Yu-Xin</creator><creator>Zuo, Chao-Ran</creator><creator>Luo, Jing-Hong</creator><creator>Wang, Pu</creator><creator>Liu, Yang-Yang</creator><creator>Zhang, Xue-Qin</creator><creator>Ye, De</creator><creator>Le, Jie</creator><creator>Chen, Li-Qun</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8698-210X</orcidid><orcidid>https://orcid.org/0000-0001-9167-4331</orcidid><orcidid>https://orcid.org/0000-0001-9621-8837</orcidid><orcidid>https://orcid.org/0000-0001-8854-3031</orcidid><orcidid>https://orcid.org/0000-0001-7053-1083</orcidid><orcidid>https://orcid.org/0000-0001-5958-6972</orcidid><orcidid>https://orcid.org/0000-0003-4953-1809</orcidid><orcidid>https://orcid.org/0000-0002-9875-3339</orcidid><orcidid>https://orcid.org/0000-0002-8179-6172</orcidid><orcidid>https://orcid.org/0000-0002-6775-8946</orcidid><orcidid>https://orcid.org/0000-0002-4346-1451</orcidid><orcidid>https://orcid.org/0000-0001-8291-3273</orcidid><orcidid>https://orcid.org/0000-0003-1988-3598</orcidid></search><sort><creationdate>20220927</creationdate><title>Arabidopsis ERdj3B coordinates with ERECTA-family receptor kinases to regulate ovule development and the heat stress response</title><author>Leng, Ya-Jun ; Yao, Ya-Sen ; Yang, Ke-Zhen ; Wu, Pei-Xiang ; Xia, Yu-Xin ; Zuo, Chao-Ran ; Luo, Jing-Hong ; Wang, Pu ; Liu, Yang-Yang ; Zhang, Xue-Qin ; Ye, De ; Le, Jie ; Chen, Li-Qun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c390t-aeed0250c85464f0648415b0887c0582908d2a22a07c17890d061904161bfb553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Arabidopsis - metabolism</topic><topic>Arabidopsis Proteins - genetics</topic><topic>Arabidopsis Proteins - metabolism</topic><topic>Carrier Proteins - metabolism</topic><topic>Heat-Shock Response</topic><topic>HSP40 Heat-Shock Proteins - metabolism</topic><topic>Ovule - metabolism</topic><topic>Protein Serine-Threonine Kinases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leng, Ya-Jun</creatorcontrib><creatorcontrib>Yao, Ya-Sen</creatorcontrib><creatorcontrib>Yang, Ke-Zhen</creatorcontrib><creatorcontrib>Wu, Pei-Xiang</creatorcontrib><creatorcontrib>Xia, Yu-Xin</creatorcontrib><creatorcontrib>Zuo, Chao-Ran</creatorcontrib><creatorcontrib>Luo, Jing-Hong</creatorcontrib><creatorcontrib>Wang, Pu</creatorcontrib><creatorcontrib>Liu, Yang-Yang</creatorcontrib><creatorcontrib>Zhang, Xue-Qin</creatorcontrib><creatorcontrib>Ye, De</creatorcontrib><creatorcontrib>Le, Jie</creatorcontrib><creatorcontrib>Chen, Li-Qun</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Plant cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leng, Ya-Jun</au><au>Yao, Ya-Sen</au><au>Yang, Ke-Zhen</au><au>Wu, Pei-Xiang</au><au>Xia, Yu-Xin</au><au>Zuo, Chao-Ran</au><au>Luo, Jing-Hong</au><au>Wang, Pu</au><au>Liu, Yang-Yang</au><au>Zhang, Xue-Qin</au><au>Ye, De</au><au>Le, Jie</au><au>Chen, Li-Qun</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arabidopsis ERdj3B coordinates with ERECTA-family receptor kinases to regulate ovule development and the heat stress response</atitle><jtitle>The Plant cell</jtitle><addtitle>Plant Cell</addtitle><date>2022-09-27</date><risdate>2022</risdate><volume>34</volume><issue>10</issue><spage>3665</spage><epage>3684</epage><pages>3665-3684</pages><issn>1040-4651</issn><eissn>1532-298X</eissn><abstract>The endoplasmic reticulum-localized DnaJ family 3B (ERdj3B), is a component of the stromal cell-derived factor 2 (SDF2)-ERdj3B-binding immunoglobulin protein (BiP) chaperone complex, which functions in protein folding, translocation, and quality control. We found that ERdj3B mutations affected integument development in the Ler ecotype but not in the Col-0 ecotype of Arabidopsis (Arabidopsis thaliana). Map-based cloning identified the ERECTA (ER) gene as a natural modifier of ERdj3B. The double mutation of ERdj3B and ER caused a major defect in the inner integument under heat stress. Additional mutation of the ER paralog ERECTA-LIKE 1 (ERL1) or ERL2 to the erdj3b er double mutant exacerbated the defective integument phenotype. The double mutation of ER and SDF2, the other component of the SDF2-ERdj3B-BiP complex, resulted in similar defects in the inner integument. Furthermore, both the protein abundance and plasma membrane partitioning of ER, ERL1, and ERL2 were markedly reduced in erdj3b plants, indicating that the SDF2-ERdj3B-BiP chaperone complex might control the translocation of ERECTA-family proteins from the endoplasmic reticulum to the plasma membrane. Our results suggest that the SDF2-ERdj3B-BiP complex functions in ovule development and the heat stress response in coordination with ERECTA-family receptor kinases.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>35897146</pmid><doi>10.1093/plcell/koac226</doi><tpages>20</tpages><orcidid>https://orcid.org/0000-0002-8698-210X</orcidid><orcidid>https://orcid.org/0000-0001-9167-4331</orcidid><orcidid>https://orcid.org/0000-0001-9621-8837</orcidid><orcidid>https://orcid.org/0000-0001-8854-3031</orcidid><orcidid>https://orcid.org/0000-0001-7053-1083</orcidid><orcidid>https://orcid.org/0000-0001-5958-6972</orcidid><orcidid>https://orcid.org/0000-0003-4953-1809</orcidid><orcidid>https://orcid.org/0000-0002-9875-3339</orcidid><orcidid>https://orcid.org/0000-0002-8179-6172</orcidid><orcidid>https://orcid.org/0000-0002-6775-8946</orcidid><orcidid>https://orcid.org/0000-0002-4346-1451</orcidid><orcidid>https://orcid.org/0000-0001-8291-3273</orcidid><orcidid>https://orcid.org/0000-0003-1988-3598</orcidid><oa>free_for_read</oa></addata></record> |
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subjects | Arabidopsis - metabolism Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Carrier Proteins - metabolism Heat-Shock Response HSP40 Heat-Shock Proteins - metabolism Ovule - metabolism Protein Serine-Threonine Kinases |
title | Arabidopsis ERdj3B coordinates with ERECTA-family receptor kinases to regulate ovule development and the heat stress response |
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