Systematic discovery of biomolecular condensate-specific protein phosphorylation

Reversible protein phosphorylation is an important mechanism for regulating (dis)assembly of biomolecular condensates. However, condensate-specific phosphosites remain largely unknown, thereby limiting our understanding of the underlying mechanisms. Here, we combine solubility proteome profiling wit...

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Veröffentlicht in:	Nature chemical biology 2022-10, Vol.18 (10), p.1104-1114
Hauptverfasser:	Sridharan, Sindhuja, Hernandez-Armendariz, Alberto, Kurzawa, Nils, Potel, Clement M., Memon, Danish, Beltrao, Pedro, Bantscheff, Marcus, Huber, Wolfgang, Cuylen-Haering, Sara, Savitski, Mikhail M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/337/1645 631/337/386 631/92/458 631/92/475 Biochemical Engineering Biochemistry Biomolecular Condensates Bioorganic Chemistry Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Condensates Kinases Nuclear Proteins - metabolism Nucleoli Phosphorylation Protein interaction Proteins Proteome - metabolism Proteomes Ribonucleic acid Ribonucleoproteins - metabolism RNA RNA - metabolism RNA Splicing Factors - metabolism Solubility Splicing Splicing factors Subpopulations
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