Condensins are essential for Pseudomonas aeruginosa corneal virulence through their control of lifestyle and virulence programs

Pseudomonas aeruginosa is a significant opportunistic pathogen responsible for numerous human infections. Its high pathogenicity resides in a diverse array of virulence factors and an ability to adapt to hostile environments. We report that these factors are tied to the activity of condensins, SMC a...

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Veröffentlicht in:	Molecular microbiology 2022-04, Vol.117 (4), p.937-957
Hauptverfasser:	Zhao, Hang, Clevenger, April L., Coburn, Phillip S., Callegan, Michelle C., Rybenkov, Valentin V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Triphosphatases Bacterial Proteins - genetics Bacterial Proteins - metabolism Biofilms Chromosomes Condensin condensins Cornea corneal infection DNA-Binding Proteins Epigenetics Gene expression Gene Expression Regulation, Bacterial Genetic programs Humans keratitis Life Style Metabolism MksB Multiprotein Complexes Mutants Opportunist infection Pathogenicity Pathogens Phenotypes Pseudomonas aeruginosa Pseudomonas aeruginosa - metabolism Pseudomonas Infections Secretion SMC Sulfur Transcription Virulence Virulence - genetics Virulence factors Virulence Factors - genetics Virulence Factors - metabolism virulence regulation
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