SARS-CoV-2 nasopharyngeal viral load in individuals infected with BA.2, compared to Alpha, Gamma, Delta and BA.1 variants: A single-center comparative analysis
•Higher nasopharyngeal viral load can influence SARS-CoV-2 transmissibility.•Higher nasopharyngeal viral load for Omicron BA.2 compared to previous variants.•Vaccination did not seem to influence the amount of nasopharyngeal viral RNA.•Our findings support the increased inherent transmissibility for...
Gespeichert in:
| Veröffentlicht in: | Journal of clinical virology 2022-12, Vol.157, p.105299-105299, Article 105299 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 105299 |
|---|---|
| container_issue | |
| container_start_page | 105299 |
| container_title | Journal of clinical virology |
| container_volume | 157 |
| creator | Mastrorosa, Ilaria Cozzi-Lepri, Alessandro Colavita, Francesca Lalle, Eleonora Mazzotta, Valentina Cimaglia, Claudia Paulicelli, Jessica Matusali, Giulia Fabeni, Lavinia Carletti, Fabrizio Rosati, Silvia Vita, Serena Giannico, Giuseppina Piselli, Pierluca Biliotti, Elisa Moghazi, Samir Al Mosti, Silvia Girardi, Enrico Nicastri, Emanuele Garbuglia, Anna Rosa Maggi, Fabrizio Vaia, Francesco Antinori, Andrea |
| description | •Higher nasopharyngeal viral load can influence SARS-CoV-2 transmissibility.•Higher nasopharyngeal viral load for Omicron BA.2 compared to previous variants.•Vaccination did not seem to influence the amount of nasopharyngeal viral RNA.•Our findings support the increased inherent transmissibility for BA.2.
SARS-CoV-2 has evolved, leading to the emergence of new Variants Of Concern (VOCs) with significant impact on transmissibility. Although the transmission process is complex, higher nasopharyngeal viral load (NP-VL) can be considered as a proxy for greater transmissibility.
The aim of this analysis was to compare NP-VL across a set of representative VOCs observed in mildly symptomatic patients.
Observational single-center comparative analysis of patients with early mild-to-moderate COVID-19, enrolled within the early treatment access program of Lazzaro Spallanzani Institute (March 2021-March 2022). NP-VL before drug administration was estimated through RT-PCR, based on cycle threshold values (CTs); VOCs were identified by Sanger sequencing. VOCs’ average treatment effect (ATE) was estimated on the CTs fitted in the log2 scale, controlling for potential confounders.
A total of 707 patients were included. VOCs were: 10% Alpha, 3% Gamma, 34% Delta, 34% BA.1, 19% BA.2. Mean CTs for BA.1 and BA.2 were lower than Delta and BA.1, respectively. After adjusting for calendar time, age, immunodeficiency and vaccination, CTs for Gamma were lower than those seen for Alpha and higher than Delta, for Delta were similar to BA.1, for BA.2 were lower than Delta and BA.1.
Our analysis shows higher NP-VL of BA.2 compared to previously circulating VOCs, even after controlling for factors potentially contributing to the amount of nasopharyngeal viral RNA, included vaccination, supporting the increased transmissibility of BA.2. Further studies are necessary to clarify this mechanism and to provide guidance for public health measures. |
| doi_str_mv | 10.1016/j.jcv.2022.105299 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9511897</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1386653222002311</els_id><sourcerecordid>2720930018</sourcerecordid><originalsourceid>FETCH-LOGICAL-c451t-a6b0619d5123673661c8ca6893ae494837ba6c792af9ef091927a597f73f88a53</originalsourceid><addsrcrecordid>eNp9kc-O0zAQxiMEYpeFB-CCfOSwKbEd_wMJKRRYkFZCYoGrNXUmrask7tpp0D4Nr4qrlhVckCx7bH_zzdi_onhOqwWtqHy1XWzdvGAVY3kvmDEPinOqFS-FkephjrmWpRScnRVPUtpWFRW8Vo-LMy6p5qKW58Wvm-brTbkMP0pGRkhht4F4N64RejL7mOc-QEv8mEfrZ9_uoU857tBN2JKfftqQd82CXRIXhh3EfDYF0vTZ5pJcwTDk5T32ExAY24OSkhmih3FKr0lDkh_XPZYOxwnjyQImP2OWQ3-XfHpaPOpySXx2Wi-K7x8_fFt-Kq-_XH1eNtelqwWdSpCrSlLTCsq4VFxK6rQDqQ0HrE2tuVqBdMow6Ax2laGGKRBGdYp3WoPgF8Xbo-9uvxqwPXSUX2930Q_5Q2wAb_-9Gf3GrsNsjaBUG5UNXp4MYrjdY5rs4JPDvocRwz5ZplhleEags5QepS6GlCJ292VoZQ9g7dZmsPYA1h7B5pwXf_d3n_GHZBa8OQow_9LsMdrkPI4OWx8zLNsG_x_731q3s_c</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2720930018</pqid></control><display><type>article</type><title>SARS-CoV-2 nasopharyngeal viral load in individuals infected with BA.2, compared to Alpha, Gamma, Delta and BA.1 variants: A single-center comparative analysis</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Mastrorosa, Ilaria ; Cozzi-Lepri, Alessandro ; Colavita, Francesca ; Lalle, Eleonora ; Mazzotta, Valentina ; Cimaglia, Claudia ; Paulicelli, Jessica ; Matusali, Giulia ; Fabeni, Lavinia ; Carletti, Fabrizio ; Rosati, Silvia ; Vita, Serena ; Giannico, Giuseppina ; Piselli, Pierluca ; Biliotti, Elisa ; Moghazi, Samir Al ; Mosti, Silvia ; Girardi, Enrico ; Nicastri, Emanuele ; Garbuglia, Anna Rosa ; Maggi, Fabrizio ; Vaia, Francesco ; Antinori, Andrea</creator><creatorcontrib>Mastrorosa, Ilaria ; Cozzi-Lepri, Alessandro ; Colavita, Francesca ; Lalle, Eleonora ; Mazzotta, Valentina ; Cimaglia, Claudia ; Paulicelli, Jessica ; Matusali, Giulia ; Fabeni, Lavinia ; Carletti, Fabrizio ; Rosati, Silvia ; Vita, Serena ; Giannico, Giuseppina ; Piselli, Pierluca ; Biliotti, Elisa ; Moghazi, Samir Al ; Mosti, Silvia ; Girardi, Enrico ; Nicastri, Emanuele ; Garbuglia, Anna Rosa ; Maggi, Fabrizio ; Vaia, Francesco ; Antinori, Andrea</creatorcontrib><description>•Higher nasopharyngeal viral load can influence SARS-CoV-2 transmissibility.•Higher nasopharyngeal viral load for Omicron BA.2 compared to previous variants.•Vaccination did not seem to influence the amount of nasopharyngeal viral RNA.•Our findings support the increased inherent transmissibility for BA.2.
SARS-CoV-2 has evolved, leading to the emergence of new Variants Of Concern (VOCs) with significant impact on transmissibility. Although the transmission process is complex, higher nasopharyngeal viral load (NP-VL) can be considered as a proxy for greater transmissibility.
The aim of this analysis was to compare NP-VL across a set of representative VOCs observed in mildly symptomatic patients.
Observational single-center comparative analysis of patients with early mild-to-moderate COVID-19, enrolled within the early treatment access program of Lazzaro Spallanzani Institute (March 2021-March 2022). NP-VL before drug administration was estimated through RT-PCR, based on cycle threshold values (CTs); VOCs were identified by Sanger sequencing. VOCs’ average treatment effect (ATE) was estimated on the CTs fitted in the log2 scale, controlling for potential confounders.
A total of 707 patients were included. VOCs were: 10% Alpha, 3% Gamma, 34% Delta, 34% BA.1, 19% BA.2. Mean CTs for BA.1 and BA.2 were lower than Delta and BA.1, respectively. After adjusting for calendar time, age, immunodeficiency and vaccination, CTs for Gamma were lower than those seen for Alpha and higher than Delta, for Delta were similar to BA.1, for BA.2 were lower than Delta and BA.1.
Our analysis shows higher NP-VL of BA.2 compared to previously circulating VOCs, even after controlling for factors potentially contributing to the amount of nasopharyngeal viral RNA, included vaccination, supporting the increased transmissibility of BA.2. Further studies are necessary to clarify this mechanism and to provide guidance for public health measures.</description><identifier>ISSN: 1386-6532</identifier><identifier>EISSN: 1873-5967</identifier><identifier>DOI: 10.1016/j.jcv.2022.105299</identifier><identifier>PMID: 36183546</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>COVID-19 ; Cycle threshold (CT) values ; Humans ; Increased transmissibility ; Nasopharyngeal viral load ; Nasopharynx ; Omicron BA.2 ; RNA, Viral - analysis ; RNA, Viral - genetics ; SARS-CoV-2 ; Variants of concern (VOCs) ; Viral Load</subject><ispartof>Journal of clinical virology, 2022-12, Vol.157, p.105299-105299, Article 105299</ispartof><rights>2022</rights><rights>Copyright © 2022. Published by Elsevier B.V.</rights><rights>2022 Published by Elsevier B.V. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c451t-a6b0619d5123673661c8ca6893ae494837ba6c792af9ef091927a597f73f88a53</citedby><cites>FETCH-LOGICAL-c451t-a6b0619d5123673661c8ca6893ae494837ba6c792af9ef091927a597f73f88a53</cites><orcidid>0000-0003-1944-662X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1386653222002311$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36183546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mastrorosa, Ilaria</creatorcontrib><creatorcontrib>Cozzi-Lepri, Alessandro</creatorcontrib><creatorcontrib>Colavita, Francesca</creatorcontrib><creatorcontrib>Lalle, Eleonora</creatorcontrib><creatorcontrib>Mazzotta, Valentina</creatorcontrib><creatorcontrib>Cimaglia, Claudia</creatorcontrib><creatorcontrib>Paulicelli, Jessica</creatorcontrib><creatorcontrib>Matusali, Giulia</creatorcontrib><creatorcontrib>Fabeni, Lavinia</creatorcontrib><creatorcontrib>Carletti, Fabrizio</creatorcontrib><creatorcontrib>Rosati, Silvia</creatorcontrib><creatorcontrib>Vita, Serena</creatorcontrib><creatorcontrib>Giannico, Giuseppina</creatorcontrib><creatorcontrib>Piselli, Pierluca</creatorcontrib><creatorcontrib>Biliotti, Elisa</creatorcontrib><creatorcontrib>Moghazi, Samir Al</creatorcontrib><creatorcontrib>Mosti, Silvia</creatorcontrib><creatorcontrib>Girardi, Enrico</creatorcontrib><creatorcontrib>Nicastri, Emanuele</creatorcontrib><creatorcontrib>Garbuglia, Anna Rosa</creatorcontrib><creatorcontrib>Maggi, Fabrizio</creatorcontrib><creatorcontrib>Vaia, Francesco</creatorcontrib><creatorcontrib>Antinori, Andrea</creatorcontrib><title>SARS-CoV-2 nasopharyngeal viral load in individuals infected with BA.2, compared to Alpha, Gamma, Delta and BA.1 variants: A single-center comparative analysis</title><title>Journal of clinical virology</title><addtitle>J Clin Virol</addtitle><description>•Higher nasopharyngeal viral load can influence SARS-CoV-2 transmissibility.•Higher nasopharyngeal viral load for Omicron BA.2 compared to previous variants.•Vaccination did not seem to influence the amount of nasopharyngeal viral RNA.•Our findings support the increased inherent transmissibility for BA.2.
SARS-CoV-2 has evolved, leading to the emergence of new Variants Of Concern (VOCs) with significant impact on transmissibility. Although the transmission process is complex, higher nasopharyngeal viral load (NP-VL) can be considered as a proxy for greater transmissibility.
The aim of this analysis was to compare NP-VL across a set of representative VOCs observed in mildly symptomatic patients.
Observational single-center comparative analysis of patients with early mild-to-moderate COVID-19, enrolled within the early treatment access program of Lazzaro Spallanzani Institute (March 2021-March 2022). NP-VL before drug administration was estimated through RT-PCR, based on cycle threshold values (CTs); VOCs were identified by Sanger sequencing. VOCs’ average treatment effect (ATE) was estimated on the CTs fitted in the log2 scale, controlling for potential confounders.
A total of 707 patients were included. VOCs were: 10% Alpha, 3% Gamma, 34% Delta, 34% BA.1, 19% BA.2. Mean CTs for BA.1 and BA.2 were lower than Delta and BA.1, respectively. After adjusting for calendar time, age, immunodeficiency and vaccination, CTs for Gamma were lower than those seen for Alpha and higher than Delta, for Delta were similar to BA.1, for BA.2 were lower than Delta and BA.1.
Our analysis shows higher NP-VL of BA.2 compared to previously circulating VOCs, even after controlling for factors potentially contributing to the amount of nasopharyngeal viral RNA, included vaccination, supporting the increased transmissibility of BA.2. Further studies are necessary to clarify this mechanism and to provide guidance for public health measures.</description><subject>COVID-19</subject><subject>Cycle threshold (CT) values</subject><subject>Humans</subject><subject>Increased transmissibility</subject><subject>Nasopharyngeal viral load</subject><subject>Nasopharynx</subject><subject>Omicron BA.2</subject><subject>RNA, Viral - analysis</subject><subject>RNA, Viral - genetics</subject><subject>SARS-CoV-2</subject><subject>Variants of concern (VOCs)</subject><subject>Viral Load</subject><issn>1386-6532</issn><issn>1873-5967</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-O0zAQxiMEYpeFB-CCfOSwKbEd_wMJKRRYkFZCYoGrNXUmrask7tpp0D4Nr4qrlhVckCx7bH_zzdi_onhOqwWtqHy1XWzdvGAVY3kvmDEPinOqFS-FkephjrmWpRScnRVPUtpWFRW8Vo-LMy6p5qKW58Wvm-brTbkMP0pGRkhht4F4N64RejL7mOc-QEv8mEfrZ9_uoU857tBN2JKfftqQd82CXRIXhh3EfDYF0vTZ5pJcwTDk5T32ExAY24OSkhmih3FKr0lDkh_XPZYOxwnjyQImP2OWQ3-XfHpaPOpySXx2Wi-K7x8_fFt-Kq-_XH1eNtelqwWdSpCrSlLTCsq4VFxK6rQDqQ0HrE2tuVqBdMow6Ax2laGGKRBGdYp3WoPgF8Xbo-9uvxqwPXSUX2930Q_5Q2wAb_-9Gf3GrsNsjaBUG5UNXp4MYrjdY5rs4JPDvocRwz5ZplhleEags5QepS6GlCJ292VoZQ9g7dZmsPYA1h7B5pwXf_d3n_GHZBa8OQow_9LsMdrkPI4OWx8zLNsG_x_731q3s_c</recordid><startdate>20221201</startdate><enddate>20221201</enddate><creator>Mastrorosa, Ilaria</creator><creator>Cozzi-Lepri, Alessandro</creator><creator>Colavita, Francesca</creator><creator>Lalle, Eleonora</creator><creator>Mazzotta, Valentina</creator><creator>Cimaglia, Claudia</creator><creator>Paulicelli, Jessica</creator><creator>Matusali, Giulia</creator><creator>Fabeni, Lavinia</creator><creator>Carletti, Fabrizio</creator><creator>Rosati, Silvia</creator><creator>Vita, Serena</creator><creator>Giannico, Giuseppina</creator><creator>Piselli, Pierluca</creator><creator>Biliotti, Elisa</creator><creator>Moghazi, Samir Al</creator><creator>Mosti, Silvia</creator><creator>Girardi, Enrico</creator><creator>Nicastri, Emanuele</creator><creator>Garbuglia, Anna Rosa</creator><creator>Maggi, Fabrizio</creator><creator>Vaia, Francesco</creator><creator>Antinori, Andrea</creator><general>Elsevier B.V</general><general>Published by Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1944-662X</orcidid></search><sort><creationdate>20221201</creationdate><title>SARS-CoV-2 nasopharyngeal viral load in individuals infected with BA.2, compared to Alpha, Gamma, Delta and BA.1 variants: A single-center comparative analysis</title><author>Mastrorosa, Ilaria ; Cozzi-Lepri, Alessandro ; Colavita, Francesca ; Lalle, Eleonora ; Mazzotta, Valentina ; Cimaglia, Claudia ; Paulicelli, Jessica ; Matusali, Giulia ; Fabeni, Lavinia ; Carletti, Fabrizio ; Rosati, Silvia ; Vita, Serena ; Giannico, Giuseppina ; Piselli, Pierluca ; Biliotti, Elisa ; Moghazi, Samir Al ; Mosti, Silvia ; Girardi, Enrico ; Nicastri, Emanuele ; Garbuglia, Anna Rosa ; Maggi, Fabrizio ; Vaia, Francesco ; Antinori, Andrea</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c451t-a6b0619d5123673661c8ca6893ae494837ba6c792af9ef091927a597f73f88a53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>COVID-19</topic><topic>Cycle threshold (CT) values</topic><topic>Humans</topic><topic>Increased transmissibility</topic><topic>Nasopharyngeal viral load</topic><topic>Nasopharynx</topic><topic>Omicron BA.2</topic><topic>RNA, Viral - analysis</topic><topic>RNA, Viral - genetics</topic><topic>SARS-CoV-2</topic><topic>Variants of concern (VOCs)</topic><topic>Viral Load</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mastrorosa, Ilaria</creatorcontrib><creatorcontrib>Cozzi-Lepri, Alessandro</creatorcontrib><creatorcontrib>Colavita, Francesca</creatorcontrib><creatorcontrib>Lalle, Eleonora</creatorcontrib><creatorcontrib>Mazzotta, Valentina</creatorcontrib><creatorcontrib>Cimaglia, Claudia</creatorcontrib><creatorcontrib>Paulicelli, Jessica</creatorcontrib><creatorcontrib>Matusali, Giulia</creatorcontrib><creatorcontrib>Fabeni, Lavinia</creatorcontrib><creatorcontrib>Carletti, Fabrizio</creatorcontrib><creatorcontrib>Rosati, Silvia</creatorcontrib><creatorcontrib>Vita, Serena</creatorcontrib><creatorcontrib>Giannico, Giuseppina</creatorcontrib><creatorcontrib>Piselli, Pierluca</creatorcontrib><creatorcontrib>Biliotti, Elisa</creatorcontrib><creatorcontrib>Moghazi, Samir Al</creatorcontrib><creatorcontrib>Mosti, Silvia</creatorcontrib><creatorcontrib>Girardi, Enrico</creatorcontrib><creatorcontrib>Nicastri, Emanuele</creatorcontrib><creatorcontrib>Garbuglia, Anna Rosa</creatorcontrib><creatorcontrib>Maggi, Fabrizio</creatorcontrib><creatorcontrib>Vaia, Francesco</creatorcontrib><creatorcontrib>Antinori, Andrea</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of clinical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mastrorosa, Ilaria</au><au>Cozzi-Lepri, Alessandro</au><au>Colavita, Francesca</au><au>Lalle, Eleonora</au><au>Mazzotta, Valentina</au><au>Cimaglia, Claudia</au><au>Paulicelli, Jessica</au><au>Matusali, Giulia</au><au>Fabeni, Lavinia</au><au>Carletti, Fabrizio</au><au>Rosati, Silvia</au><au>Vita, Serena</au><au>Giannico, Giuseppina</au><au>Piselli, Pierluca</au><au>Biliotti, Elisa</au><au>Moghazi, Samir Al</au><au>Mosti, Silvia</au><au>Girardi, Enrico</au><au>Nicastri, Emanuele</au><au>Garbuglia, Anna Rosa</au><au>Maggi, Fabrizio</au><au>Vaia, Francesco</au><au>Antinori, Andrea</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>SARS-CoV-2 nasopharyngeal viral load in individuals infected with BA.2, compared to Alpha, Gamma, Delta and BA.1 variants: A single-center comparative analysis</atitle><jtitle>Journal of clinical virology</jtitle><addtitle>J Clin Virol</addtitle><date>2022-12-01</date><risdate>2022</risdate><volume>157</volume><spage>105299</spage><epage>105299</epage><pages>105299-105299</pages><artnum>105299</artnum><issn>1386-6532</issn><eissn>1873-5967</eissn><abstract>•Higher nasopharyngeal viral load can influence SARS-CoV-2 transmissibility.•Higher nasopharyngeal viral load for Omicron BA.2 compared to previous variants.•Vaccination did not seem to influence the amount of nasopharyngeal viral RNA.•Our findings support the increased inherent transmissibility for BA.2.
SARS-CoV-2 has evolved, leading to the emergence of new Variants Of Concern (VOCs) with significant impact on transmissibility. Although the transmission process is complex, higher nasopharyngeal viral load (NP-VL) can be considered as a proxy for greater transmissibility.
The aim of this analysis was to compare NP-VL across a set of representative VOCs observed in mildly symptomatic patients.
Observational single-center comparative analysis of patients with early mild-to-moderate COVID-19, enrolled within the early treatment access program of Lazzaro Spallanzani Institute (March 2021-March 2022). NP-VL before drug administration was estimated through RT-PCR, based on cycle threshold values (CTs); VOCs were identified by Sanger sequencing. VOCs’ average treatment effect (ATE) was estimated on the CTs fitted in the log2 scale, controlling for potential confounders.
A total of 707 patients were included. VOCs were: 10% Alpha, 3% Gamma, 34% Delta, 34% BA.1, 19% BA.2. Mean CTs for BA.1 and BA.2 were lower than Delta and BA.1, respectively. After adjusting for calendar time, age, immunodeficiency and vaccination, CTs for Gamma were lower than those seen for Alpha and higher than Delta, for Delta were similar to BA.1, for BA.2 were lower than Delta and BA.1.
Our analysis shows higher NP-VL of BA.2 compared to previously circulating VOCs, even after controlling for factors potentially contributing to the amount of nasopharyngeal viral RNA, included vaccination, supporting the increased transmissibility of BA.2. Further studies are necessary to clarify this mechanism and to provide guidance for public health measures.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>36183546</pmid><doi>10.1016/j.jcv.2022.105299</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1944-662X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1386-6532 |
| ispartof | Journal of clinical virology, 2022-12, Vol.157, p.105299-105299, Article 105299 |
| issn | 1386-6532 1873-5967 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9511897 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | COVID-19 Cycle threshold (CT) values Humans Increased transmissibility Nasopharyngeal viral load Nasopharynx Omicron BA.2 RNA, Viral - analysis RNA, Viral - genetics SARS-CoV-2 Variants of concern (VOCs) Viral Load |
| title | SARS-CoV-2 nasopharyngeal viral load in individuals infected with BA.2, compared to Alpha, Gamma, Delta and BA.1 variants: A single-center comparative analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T21%3A07%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=SARS-CoV-2%20nasopharyngeal%20viral%20load%20in%20individuals%20infected%20with%20BA.2,%20compared%20to%20Alpha,%20Gamma,%20Delta%20and%20BA.1%20variants:%20A%20single-center%20comparative%20analysis&rft.jtitle=Journal%20of%20clinical%20virology&rft.au=Mastrorosa,%20Ilaria&rft.date=2022-12-01&rft.volume=157&rft.spage=105299&rft.epage=105299&rft.pages=105299-105299&rft.artnum=105299&rft.issn=1386-6532&rft.eissn=1873-5967&rft_id=info:doi/10.1016/j.jcv.2022.105299&rft_dat=%3Cproquest_pubme%3E2720930018%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2720930018&rft_id=info:pmid/36183546&rft_els_id=S1386653222002311&rfr_iscdi=true |