Virtual screening for small-molecule pathway regulators by image-profile matching

Identifying the chemical regulators of biological pathways is a time-consuming bottleneck in developing therapeutics and research compounds. Typically, thousands to millions of candidate small molecules are tested in target-based biochemical screens or phenotypic cell-based screens, both expensive e...

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Veröffentlicht in:	Cell systems 2022-09, Vol.13 (9), p.724-736.e9
Hauptverfasser:	Rohban, Mohammad H., Fuller, Ashley M., Tan, Ceryl, Goldstein, Jonathan T., Syangtan, Deepsing, Gutnick, Amos, DeVine, Ann, Nijsure, Madhura P., Rigby, Megan, Sacher, Joshua R., Corsello, Steven M., Peppler, Grace B., Bogaczynska, Marta, Boghossian, Andrew, Ciotti, Gabrielle E., Hands, Allison T., Mekareeya, Aroonroj, Doan, Minh, Gale, Jennifer P., Derynck, Rik, Turbyville, Thomas, Boerckel, Joel D., Singh, Shantanu, Kiessling, Laura L., Schwarz, Thomas L., Varelas, Xaralabos, Wagner, Florence F., Kafri, Ran, Eisinger-Mathason, T.S. Karin, Carpenter, Anne E.
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line computational drug discovery drug screening Hippo/Yap1 pathway image-based profiling Prospective Studies Retrospective Studies virtual screening
Online-Zugang:	Volltext
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