Rapid and Efficient Spatiotemporal Monitoring of Normal and Aberrant Cytosine Methylation within Intact Zebrafish Embryos

Cytosine methylation is highly conserved across vertebrate species and, as a key driver of epigenetic programming and chromatin state, plays a critical role in early embryonic development. Enzymatic modifications drive active methylation and demethylation of cytosine into 5-methylcytosine (5-mC) and...

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Veröffentlicht in:	Journal of visualized experiments 2022-08 (186)
Hauptverfasser:	Avila-Barnard, Sarah, Volz, David C.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-methylcytosine adults automation chromatin cost effectiveness Danio rerio demethylation disease susceptibility DNA methylation early development embryogenesis epigenetics epigenome immunohistochemistry maternal exposure oxidation phenotype progeny statistical analysis
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