Tissue-resident memory and circulating T cells are early responders to pre-surgical cancer immunotherapy

Neoadjuvant immune checkpoint blockade has shown promising clinical activity. Here, we characterized early kinetics in tumor-infiltrating and circulating immune cells in oral cancer patients treated with neoadjuvant anti-PD-1 or anti-PD-1/CTLA-4 in a clinical trial (NCT02919683). Tumor-infiltrating...

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Veröffentlicht in:	Cell 2022-08, Vol.185 (16), p.2918-2935.e29
Hauptverfasser:	Luoma, Adrienne M., Suo, Shengbao, Wang, Yifan, Gunasti, Lauren, Porter, Caroline B.M., Nabilsi, Nancy, Tadros, Jenny, Ferretti, Andrew P., Liao, Sida, Gurer, Cagan, Chen, Yu-Hui, Criscitiello, Shana, Ricker, Cora A., Dionne, Danielle, Rozenblatt-Rosen, Orit, Uppaluri, Ravindra, Haddad, Robert I., Ashenberg, Orr, Regev, Aviv, Van Allen, Eliezer M., MacBeath, Gavin, Schoenfeld, Jonathan D., Wucherpfennig, Kai W.
Format:	Artikel
Sprache:	eng
Schlagworte:	cancer CD8-Positive T-Lymphocytes Humans Immunotherapy Lymphocytes, Tumor-Infiltrating Neoadjuvant Therapy Neoplasms - therapy Programmed Cell Death 1 Receptor single-cell RNA sequencing T cells tissue-resident memory T cells Tumor Microenvironment
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