HBsAg may reappear following reactivation in individuals with spontaneous HBsAg seroclearance 8 years previously
HBsAg reappearance may constitute not only a risk for liver disease but also an infectious source. We aimed to determine whether HBsAg may reappear after spontaneous HBsAg seroclearance. A cohort of 2999 HBsAg-positive subjects aged 30–55 years was recruited in Guangxi, China in 2004. HBsAg was test...
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| Veröffentlicht in: | Epidemiology and infection 2017-03, Vol.145 (4), p.728-738 |
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| creator | CHEN, Q. Y. WANG, X. Y. HARRISON, T. J. HE, X. HU, L. P. LI, K. W. JIA, H. H. YANG, Q. L. WANG, C. FANG, Z. L. |
| description | HBsAg reappearance may constitute not only a risk for liver disease but also an infectious source. We aimed to determine whether HBsAg may reappear after spontaneous HBsAg seroclearance. A cohort of 2999 HBsAg-positive subjects aged 30–55 years was recruited in Guangxi, China in 2004. HBsAg was tested every 6 months from July 2004 to June 2007, then, one more time in December 2013. The results showed that spontaneous HBsAg seroclearance occurred in 41 subjects in the first 3 years, giving a 0·54% annual seroclearance rate. Thirteen of the 41 subjects were randomly tested for HBsAg in 2013. Four subjects became HBsAg positive. S gene sequences of HBV were analysed from serum collected before seroclearance and after reappearance, respectively, for subject QS840 (11 and 12 clones), subject TN98 (13 and 13 clones) and subject WX227 (10 and 8 clones). Serotype, subgenotype and amino-acid substitution pattern in each sample collected after reappearance was observed in the sample collected before HBsAg seroclearance. Nucleotide similarity between the two sequences from each subject was >99% and five sequences from subject TN98 were the same. In conclusion, following reactivation, HBsAg may reappear in individuals with spontaneous HBsAg seroclearance many years previously. |
| doi_str_mv | 10.1017/S095026881600279X |
| format | Article |
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Y. ; WANG, X. Y. ; HARRISON, T. J. ; HE, X. ; HU, L. P. ; LI, K. W. ; JIA, H. H. ; YANG, Q. L. ; WANG, C. ; FANG, Z. L.</creator><creatorcontrib>CHEN, Q. Y. ; WANG, X. Y. ; HARRISON, T. J. ; HE, X. ; HU, L. P. ; LI, K. W. ; JIA, H. H. ; YANG, Q. L. ; WANG, C. ; FANG, Z. L.</creatorcontrib><description>HBsAg reappearance may constitute not only a risk for liver disease but also an infectious source. We aimed to determine whether HBsAg may reappear after spontaneous HBsAg seroclearance. A cohort of 2999 HBsAg-positive subjects aged 30–55 years was recruited in Guangxi, China in 2004. HBsAg was tested every 6 months from July 2004 to June 2007, then, one more time in December 2013. The results showed that spontaneous HBsAg seroclearance occurred in 41 subjects in the first 3 years, giving a 0·54% annual seroclearance rate. Thirteen of the 41 subjects were randomly tested for HBsAg in 2013. Four subjects became HBsAg positive. S gene sequences of HBV were analysed from serum collected before seroclearance and after reappearance, respectively, for subject QS840 (11 and 12 clones), subject TN98 (13 and 13 clones) and subject WX227 (10 and 8 clones). Serotype, subgenotype and amino-acid substitution pattern in each sample collected after reappearance was observed in the sample collected before HBsAg seroclearance. Nucleotide similarity between the two sequences from each subject was >99% and five sequences from subject TN98 were the same. In conclusion, following reactivation, HBsAg may reappear in individuals with spontaneous HBsAg seroclearance many years previously.</description><identifier>ISSN: 0950-2688</identifier><identifier>EISSN: 1469-4409</identifier><identifier>DOI: 10.1017/S095026881600279X</identifier><identifier>PMID: 27917751</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adult ; China ; Cohort Studies ; Consent ; Female ; Genotype ; Hepatitis B ; Hepatitis B - pathology ; Hepatitis B Surface Antigens - blood ; Hepatitis B Surface Antigens - genetics ; Hepatitis B virus - classification ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Hepatitis B virus - physiology ; Humans ; Infections ; Liver cancer ; Liver cirrhosis ; Male ; Middle Aged ; Mutation ; Original Papers ; Polymerase chain reaction ; Recurrence ; Sequence Analysis, DNA ; Serology ; Statistical analysis ; Time ; Virus Activation</subject><ispartof>Epidemiology and infection, 2017-03, Vol.145 (4), p.728-738</ispartof><rights>Copyright © Cambridge University Press 2016</rights><rights>Cambridge University Press 2016</rights><rights>Cambridge University Press 2016 2016 Cambridge University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c493t-54129e68bdf7a63f9e7e28ced25366cda5a16e0e731570f6225d2d8ccffb0ea73</citedby><cites>FETCH-LOGICAL-c493t-54129e68bdf7a63f9e7e28ced25366cda5a16e0e731570f6225d2d8ccffb0ea73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/26521141$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/26521141$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27917751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>CHEN, Q. Y.</creatorcontrib><creatorcontrib>WANG, X. Y.</creatorcontrib><creatorcontrib>HARRISON, T. J.</creatorcontrib><creatorcontrib>HE, X.</creatorcontrib><creatorcontrib>HU, L. P.</creatorcontrib><creatorcontrib>LI, K. W.</creatorcontrib><creatorcontrib>JIA, H. H.</creatorcontrib><creatorcontrib>YANG, Q. L.</creatorcontrib><creatorcontrib>WANG, C.</creatorcontrib><creatorcontrib>FANG, Z. L.</creatorcontrib><title>HBsAg may reappear following reactivation in individuals with spontaneous HBsAg seroclearance 8 years previously</title><title>Epidemiology and infection</title><addtitle>Epidemiol. Infect</addtitle><description>HBsAg reappearance may constitute not only a risk for liver disease but also an infectious source. We aimed to determine whether HBsAg may reappear after spontaneous HBsAg seroclearance. A cohort of 2999 HBsAg-positive subjects aged 30–55 years was recruited in Guangxi, China in 2004. HBsAg was tested every 6 months from July 2004 to June 2007, then, one more time in December 2013. The results showed that spontaneous HBsAg seroclearance occurred in 41 subjects in the first 3 years, giving a 0·54% annual seroclearance rate. Thirteen of the 41 subjects were randomly tested for HBsAg in 2013. Four subjects became HBsAg positive. S gene sequences of HBV were analysed from serum collected before seroclearance and after reappearance, respectively, for subject QS840 (11 and 12 clones), subject TN98 (13 and 13 clones) and subject WX227 (10 and 8 clones). Serotype, subgenotype and amino-acid substitution pattern in each sample collected after reappearance was observed in the sample collected before HBsAg seroclearance. Nucleotide similarity between the two sequences from each subject was >99% and five sequences from subject TN98 were the same. In conclusion, following reactivation, HBsAg may reappear in individuals with spontaneous HBsAg seroclearance many years previously.</description><subject>Adult</subject><subject>China</subject><subject>Cohort Studies</subject><subject>Consent</subject><subject>Female</subject><subject>Genotype</subject><subject>Hepatitis B</subject><subject>Hepatitis B - pathology</subject><subject>Hepatitis B Surface Antigens - blood</subject><subject>Hepatitis B Surface Antigens - genetics</subject><subject>Hepatitis B virus - classification</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B virus - physiology</subject><subject>Humans</subject><subject>Infections</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mutation</subject><subject>Original Papers</subject><subject>Polymerase chain reaction</subject><subject>Recurrence</subject><subject>Sequence Analysis, DNA</subject><subject>Serology</subject><subject>Statistical analysis</subject><subject>Time</subject><subject>Virus Activation</subject><issn>0950-2688</issn><issn>1469-4409</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kV1rFDEUhoModq3-AC-UgDfeTJtkZvJxI7TF2kKhFyp4F7LJmW2WmcmYzGzZf2-G2daqCIGEvM95zxdCbyk5oYSK069E1YRxKSknhAn14xla0YqroqqIeo5Ws1zM-hF6ldKWEKKYFC_RUWapEDVdoeHqPJ1tcGf2OIIZBjARN6Ftw73vN_OXHf3OjD702M_H-Z13k2kTvvfjHU5D6EfTQ5gSXpwSxGDbbGN6C1jifX4mPETY-Qy1-9foRZPD4c3hPkbfLz9_u7gqbm6_XF-c3RS2UuVY1BVlCrhcu0YYXjYKBDBpwbG65Nw6UxvKgYAoaS1IwxmrHXPS2qZZEzCiPEafFt9hWnfgLPRjNK0eou9M3OtgvP5T6f2d3oSdzjPLoymzwceDQQw_J0ij7nyy0LZLu5rKiuehM6ky-uEvdBum2Of2MiU54yUhNFN0oWwMKUVoHouhRM_71P_sM8e8f9rFY8TDAjPwbgG2aQzxt85rRmk16-UhqenW0bsNPKntv2l_AQSytxk</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>CHEN, Q. 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Y.</au><au>WANG, X. Y.</au><au>HARRISON, T. J.</au><au>HE, X.</au><au>HU, L. P.</au><au>LI, K. W.</au><au>JIA, H. H.</au><au>YANG, Q. L.</au><au>WANG, C.</au><au>FANG, Z. L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>HBsAg may reappear following reactivation in individuals with spontaneous HBsAg seroclearance 8 years previously</atitle><jtitle>Epidemiology and infection</jtitle><addtitle>Epidemiol. Infect</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>145</volume><issue>4</issue><spage>728</spage><epage>738</epage><pages>728-738</pages><issn>0950-2688</issn><eissn>1469-4409</eissn><abstract>HBsAg reappearance may constitute not only a risk for liver disease but also an infectious source. We aimed to determine whether HBsAg may reappear after spontaneous HBsAg seroclearance. A cohort of 2999 HBsAg-positive subjects aged 30–55 years was recruited in Guangxi, China in 2004. HBsAg was tested every 6 months from July 2004 to June 2007, then, one more time in December 2013. The results showed that spontaneous HBsAg seroclearance occurred in 41 subjects in the first 3 years, giving a 0·54% annual seroclearance rate. Thirteen of the 41 subjects were randomly tested for HBsAg in 2013. Four subjects became HBsAg positive. S gene sequences of HBV were analysed from serum collected before seroclearance and after reappearance, respectively, for subject QS840 (11 and 12 clones), subject TN98 (13 and 13 clones) and subject WX227 (10 and 8 clones). Serotype, subgenotype and amino-acid substitution pattern in each sample collected after reappearance was observed in the sample collected before HBsAg seroclearance. Nucleotide similarity between the two sequences from each subject was >99% and five sequences from subject TN98 were the same. In conclusion, following reactivation, HBsAg may reappear in individuals with spontaneous HBsAg seroclearance many years previously.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>27917751</pmid><doi>10.1017/S095026881600279X</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Epidemiology and infection, 2017-03, Vol.145 (4), p.728-738 |
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| subjects | Adult China Cohort Studies Consent Female Genotype Hepatitis B Hepatitis B - pathology Hepatitis B Surface Antigens - blood Hepatitis B Surface Antigens - genetics Hepatitis B virus - classification Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B virus - physiology Humans Infections Liver cancer Liver cirrhosis Male Middle Aged Mutation Original Papers Polymerase chain reaction Recurrence Sequence Analysis, DNA Serology Statistical analysis Time Virus Activation |
| title | HBsAg may reappear following reactivation in individuals with spontaneous HBsAg seroclearance 8 years previously |
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