A Prospective, Case-Control Study of Serum Metabolomics in Neonates with Late-Onset Sepsis and Necrotizing Enterocolitis
Late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) are major causes of neonatal morbidity and mortality. In this prospective, case-control study, we evaluated the metabolic profile of neonates with LOS and NEC. Blood samples were collected from 15 septic neonates and 17 neonates with NEC at...
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| Veröffentlicht in: | Journal of clinical medicine 2022-09, Vol.11 (18), p.5270 |
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| creator | Thomaidou, Agathi Deda, Olga Begou, Olga Lioupi, Artemis Kontou, Angeliki Gika, Helen Agakidou, Eleni Theodoridis, Georgios Sarafidis, Kosmas |
| description | Late-onset sepsis (LOS) and necrotizing enterocolitis (NEC) are major causes of neonatal morbidity and mortality. In this prospective, case-control study, we evaluated the metabolic profile of neonates with LOS and NEC. Blood samples were collected from 15 septic neonates and 17 neonates with NEC at the clinical suspicion of the specific diseases. Sixteen gestational and postnatal age-matched neonates without sepsis/NEC served as controls. Serum metabolic profiles were assessed using liquid chromatography–quadrupole time-of-flight mass spectrometry. Metabolomic analysis revealed significant differences in the metabolic profile of neonates with LOS or NEC compared to controls. More specifically, a number of molecules possibly identified as phosphatidylcholines or lysophosphatidylcholines were found to be significantly reduced both in neonates with LOS and those with NEC compared to controls. Additionally, L-carnitine could efficiently discriminate NEC cases from controls. The results of the current study suggest that certain phospholipids and their derivatives could possibly be used as biomarkers for the early detection of LOS and NEC. |
| doi_str_mv | 10.3390/jcm11185270 |
| format | Article |
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In this prospective, case-control study, we evaluated the metabolic profile of neonates with LOS and NEC. Blood samples were collected from 15 septic neonates and 17 neonates with NEC at the clinical suspicion of the specific diseases. Sixteen gestational and postnatal age-matched neonates without sepsis/NEC served as controls. Serum metabolic profiles were assessed using liquid chromatography–quadrupole time-of-flight mass spectrometry. Metabolomic analysis revealed significant differences in the metabolic profile of neonates with LOS or NEC compared to controls. More specifically, a number of molecules possibly identified as phosphatidylcholines or lysophosphatidylcholines were found to be significantly reduced both in neonates with LOS and those with NEC compared to controls. Additionally, L-carnitine could efficiently discriminate NEC cases from controls. The results of the current study suggest that certain phospholipids and their derivatives could possibly be used as biomarkers for the early detection of LOS and NEC.</description><identifier>ISSN: 2077-0383</identifier><identifier>EISSN: 2077-0383</identifier><identifier>DOI: 10.3390/jcm11185270</identifier><identifier>PMID: 36142917</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Biomarkers ; Birth weight ; Blood ; Chromatography ; Disease ; Enteral nutrition ; Gastrointestinal diseases ; Laboratories ; Mass spectrometry ; Metabolism ; Metabolites ; Mortality ; Necrosis ; Newborn babies ; Pathophysiology ; Premature babies ; Scientific imaging ; Sepsis ; Urine</subject><ispartof>Journal of clinical medicine, 2022-09, Vol.11 (18), p.5270</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). 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In this prospective, case-control study, we evaluated the metabolic profile of neonates with LOS and NEC. Blood samples were collected from 15 septic neonates and 17 neonates with NEC at the clinical suspicion of the specific diseases. Sixteen gestational and postnatal age-matched neonates without sepsis/NEC served as controls. Serum metabolic profiles were assessed using liquid chromatography–quadrupole time-of-flight mass spectrometry. Metabolomic analysis revealed significant differences in the metabolic profile of neonates with LOS or NEC compared to controls. More specifically, a number of molecules possibly identified as phosphatidylcholines or lysophosphatidylcholines were found to be significantly reduced both in neonates with LOS and those with NEC compared to controls. Additionally, L-carnitine could efficiently discriminate NEC cases from controls. The results of the current study suggest that certain phospholipids and their derivatives could possibly be used as biomarkers for the early detection of LOS and NEC.</description><subject>Biomarkers</subject><subject>Birth weight</subject><subject>Blood</subject><subject>Chromatography</subject><subject>Disease</subject><subject>Enteral nutrition</subject><subject>Gastrointestinal diseases</subject><subject>Laboratories</subject><subject>Mass spectrometry</subject><subject>Metabolism</subject><subject>Metabolites</subject><subject>Mortality</subject><subject>Necrosis</subject><subject>Newborn babies</subject><subject>Pathophysiology</subject><subject>Premature babies</subject><subject>Scientific imaging</subject><subject>Sepsis</subject><subject>Urine</subject><issn>2077-0383</issn><issn>2077-0383</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNpdkV1rFTEQhoMottRe-QcC3gi6mo_N141QDvUDjlaoXodsdrbNYTc5Jtlq_fXm0CLVuZkX5uHlnRmEnlPyhnND3u78QinVginyCB0zolRHuOaPH-gjdFrKjrTSumdUPUVHXNKeGaqO0a8z_DWnsgdfww28xhtXoNukWHOa8WVdx1ucJnwJeV3wZ6huSHNagi84RPwFUnQVCv4Z6jXeNtldxAK14fsSCnZxbIzPqYbfIV7h81ghJ5_mUEN5hp5Mbi5wet9P0Pf35982H7vtxYdPm7Nt57mWtRNjP4ySK0G0cJRrJtXAnBdCGi8GA0TLBggvDIyUiN5M0g3aAGNC-X4i_AS9u_Pdr8MCo4e2mpvtPofF5VubXLD_TmK4tlfpxhpBhGSqGby8N8jpxwql2iUUD_PsIqS1WKaokob0hDf0xX_oLq05tvUOlBSCC3NI9OqOapcpJcP0Nwwl9vBU--Cp_A9Pk5Pe</recordid><startdate>20220907</startdate><enddate>20220907</enddate><creator>Thomaidou, Agathi</creator><creator>Deda, Olga</creator><creator>Begou, Olga</creator><creator>Lioupi, Artemis</creator><creator>Kontou, Angeliki</creator><creator>Gika, Helen</creator><creator>Agakidou, Eleni</creator><creator>Theodoridis, Georgios</creator><creator>Sarafidis, Kosmas</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-7361-0510</orcidid><orcidid>https://orcid.org/0000-0002-6806-6343</orcidid><orcidid>https://orcid.org/0000-0003-0004-4866</orcidid><orcidid>https://orcid.org/0000-0002-2015-108X</orcidid><orcidid>https://orcid.org/0000-0002-1893-937X</orcidid><orcidid>https://orcid.org/0000-0003-3642-7367</orcidid></search><sort><creationdate>20220907</creationdate><title>A Prospective, Case-Control Study of Serum Metabolomics in Neonates with Late-Onset Sepsis and Necrotizing Enterocolitis</title><author>Thomaidou, Agathi ; 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| subjects | Biomarkers Birth weight Blood Chromatography Disease Enteral nutrition Gastrointestinal diseases Laboratories Mass spectrometry Metabolism Metabolites Mortality Necrosis Newborn babies Pathophysiology Premature babies Scientific imaging Sepsis Urine |
| title | A Prospective, Case-Control Study of Serum Metabolomics in Neonates with Late-Onset Sepsis and Necrotizing Enterocolitis |
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